M. Ziya Alkan's research while affiliated with Ege University and other places
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Publications (29)
The diagnosis of canine leishmaniasis (CanL) in symptomatic and asymptomatic dogs is a very important and problematic public health issue in Turkey. A longitudinal study was carried out on dogs in selected villages in the Çukurova Plain in Turkey, from July 2011 to June 2013, where cutaneous (CL) and visceral (VL) leishmaniasis is endemic. The stud...
Canine leishmaniasis is an important veterinary and public health problem in numerous areas of
Turkey. The aim of the present study was to evaluate the diagnostic value of conjunctival swab
nested-PCR (CS n-PCR) for the detection of the presence of Leishmania parasite and
comparison with the performance of the indirect immunofluorescence antibody t...
The ITS1 region including the variable region used for designing probes in Turkish Leishmania isolates. [REF*: the sequences were taken from published paper, Talmi-Frank et al. (47); VL: visceral isolates; CL: cutaneous isolates; CanL: dog isolates].
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Identification of Turkish Leishmania isolates by ITS1 real time PCR method and isoenzymatic method.
(DOCX)
STARD checklist for reporting of the study.
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STARD Flowchart of the present study.
(TIF)
Human visceral leishmaniasis (VL) caused by L. infantum and cutaneous leishmaniasis (CL) caused by L. tropica and L. infantum have been reported in Turkey. L. infantum is also responsible for canine leishmaniasis (CanL) and it is widely common in the country. The main aim of the present study was to design a real-time PCR method based on the intern...
##Assembly-Data-START## Sequencing Technology :: Sanger dideoxy sequencing ##Assembly-Data-END##
Leishmaniases are present in two clinical forms, as visceral and cutaneous, in Turkey showing a tendency of spreading throughout the country. The aim of the present study was to produce a new model for determining the spatial risk levels using the data in a selected study site in the western part of Turkey. The results of entomological studies in t...
Malaria was expected to be a major problem during blood donation in Turkey due to existence of malaria cases in southeastern region of Turkey. The present study aimed for the first time, to investigate malaria in "donors deferred for malaria risk" and to determine the regional rates of malaria deferral in Turkey. Blood samples were collected from s...
An entomological survey was conducted to determine the spatial distribution of phlebotomine fauna and understand the effect of environmental factors. The entomological survey was carried out during 2006-2007 in a study area in the rural area of Aydin province, near the Kusadasi town where VL, CL, and canine leishmaniasis (CanL) are endemic. In 2006...
Human leishmaniasis, both visceral and cutaneous, and canine leishmaniasis have been reported in Turkey for centuries. However, the advent of new diagnostic tools during the last 30 years has led to the recognition that leishmaniasis is an important public health problem throughout the country. In most disease foci both canine and human leishmanias...
The acid-fast staining method is widely used in the diagnosis of cryptosporidiosis, a disease causing diarrhea in humans. However in this technique, some of Cryptosporidium spp oocysts can not be stained and seen as formed "ghost-like bodies" and which can only be evaluated by experienced microscopists. In the recent years, PCR technique which is p...
Human visceral leishmaniasis (HVL), caused by Leishmania infantum is mainly observed as sporadic cases in Turkey and dogs are considered as the main reservoir of the disease. The incidence of visceral leishmaniasis among members of households where a HVL infection has already been diagnosed was studied in clusters around the diagnosed cases in diff...
Epidemiological, clinical and laboratory data were collected during an outbreak of trichinellosis, which occurred in Izmir, Turkey, between January and March 2004. The source of the infection was raw meatballs made with a mixture of uncooked beef and pork. Of 474 persons who were admitted at the Ataturk Training and Research Hospital during this pe...
This study aimed to evaluate clinical signs related with canine leishmaniosis (CanL) and to determine their relation with serological results in the differential diagnosis of this disease in dog populations. A total of 253 dogs from houses and a dog shelter in Kufladas›, an endemic region for leishmaniosis, were investigated for clinical signs rela...
Human and canine visceral leishmaniasis cases have been reported from Kuşadasi, a town in western Turkey, since 1993. In orcer to better understand the epidemiology of canine visceral leishmaniasis (CanVL) in the region, we aimed: (i) to determine the prevalence of CanVL in Kuşadasi using a randomly selected dog population and (ii) to measure the e...
K39 is a repetitive immunodominant epitope in a kinesin-related protein expressed predominantly in the amastigotes of visceral Leishmania spp. Enzyme immunoassays of patient's sera with recombinant K39 (rK39) proved to be highly specific and sensitive for diagnosis of active visceral leishmaniasis (VL, kala-azar). The same assays in dipstick format...
Human visceral leishmaniasis (VL) caused by Leishmania infantum is found throughout the Mediterranean Region, including Turkey, where dogs are considered to be the main reservoir host for this parasite. In the district of Manisa, western Turkey, 37 human VL cases were reported from June 1993-August 1997. Twenty-four villages in this district were c...
Infantile Mediterranean visceral leishmaniasis (IVL) and anthroponotic cutaneous leishmaniasis (ACL) have long been known to exist in the western and southeastern Turkey, respectively. To further study these and other related diseases, a recombinant antigen (rK39) specific to VL was used in an ELISA for serodiagnosis of selected patients and for sc...
Two clinical forms of leishmaniasis have been observed in Turkey, cutaneous (CL) and visceral (VL) Unitl now, VL cases were firstly reported from two villages of Karabük (western Black Sea region of Turkey). These villages have population of 300, 1030 m altitude and high humidity due to long rain period. Initial entomological study was carried out...
The leishmaniases are a widespread and medically important group of parasitic diseases, some of which pose a serious health threat in communities throughout the Mediterranean basin. In 1993, a joint, collaborative study of the Mediterranean leishmaniases was initiated by scientists from Israel, Turkey, Portugal and the Netherlands. The aim of this...
Bone-marrow aspiration and biopsy material samples obtained from two patients, one diagnosed as visceral and other as cutaneous leishmaniasis, were inoculated in Novy, McNeal, Nicolle (NNN) medium and nutrient broth (NB), containing fetal calf serum (FCS), penicillin and streptomycine. Both media were incubated at 27 degrees C for 10 days and obser...
Urethral discharge of 415 male patients, age 18-50, were examined for Trichomonas vaginalis by direct examination of fresh and Giemsa-stained slides and cultivation in CPLM media. In this study, 85 (20.7%) specimens out of 415, were found to be positive for trichomoniasis. Three groups consisting of 30, 29 and 26 patients each was treated with secn...
Citations
... There were many studies on CanL in Turkiye. These were in Aegean Region (9%), Mugla (37,4%), Antalya (7.95%), Hatay (0.8%) and Northern Cyprus (1.9%), Middle Black Sea Region (0,41%), Western Part of Turkiye, Bursa (5.5%), Edirne (100%), Istanbul (0%), Diyarbakır (0%), Western Black Sea-Karabuk (8%), Sakarya (1.45%), Kocaeli (3.07%), Kusadası (4.1%), Izmir (3.2%) (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). Some of these studies were studied serologically and some of them were investigated by molecular methods. ...
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... Plasmodium species, vectors of malaria and seasonal distribution of malaria cases in Turkey P. vivax is the only reported species from autochthonous cases and cases with other Plasmodium species are reported as imported cases of malaria in Turkey. Nevertheless, both P. malariae and P. falciparum may still have the potential to re-emerge in future (Alten et al., 2007;MoH, 2010;Anon, 2010a;Unat et al., 1965;Alkan et al., 1995;Aslan et al., 2007;Dilmec et al., 2010). The patients who are 15 years old and above are treated with 30 mg primaquine/day for 14 days and chloroquine given 600 mg followed by 300 mg 6 h later and 300 mg once a day at second and third days (MoH, 2010). ...
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... With the target of Leishmania DNA amplification in CS samples of stray dogs and cats, both the nested PCR and qPCR have proved their efficiency in the diagnosis of leishmaniasis (Gramiccia et al., 2010;Karakuş et al., 2019). The sensitivity of CS-nested PCR (41.74%) was higher than IFAT (27.18%) in detecting Leishmania-dogs interaction (Karakuş et al., 2015). ...
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... This disease has became a greater threat in recent years, since economic opportunities in the provinces of the South-eastern Anatolia Irrigation Project (GAP) have attracted human populations to Sanliurfa. Ozensoy et al. (1997) reported that the number of documented cases of cutaneous leishmaniasis had risen in Sanliurfa from 552 in 1990, to 1955 in 1993. In the first 9 months of 1994 alone the number of reported cases was already over 3000. ...
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... VL Türkiye'de çoğunlukla Ege ve Akdeniz bölgelerinde görülmekle birlikte hemen hemen bütün bölgelerimizden vakalar bildirilmiştir (6,7). Parazitin doğadaki rezervuarlığını köpekler yapmakta ve bu hayvanlarda görülen hastalığa "Kanin Leishmaniasis" (KanL) adı verilmektedir (1,8). Hastalığın bir bölgede endemik veya sporadik olgularla devam etmesinde köpeklerin önemli rolü olduğu gibi, hastalığın o bölgedeki durumu hakkında da bilgi vermektedir (9,10). ...
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... Ülkemizde hastalık Ege ve Akdeniz bölgelerinde endemik, diğer bölgelerde ise sporadik seyretmektedir. Türkiye'de yapılan moleküler düzeydeki çalışmalarda VL'de etkenin L. infantum olduğu saptanmıştır (2). Ana rezervuarı köpekler ve kemiricilerdir. ...
... This case may explain the causes of the higher seroprevalence of CanL in Northern Cyprus. A large proportion of dogs with CanL do not show any clinical signs (10,20,22). Similar to those findings, in this study, only four out of 10 seropositive dogs (40%) showed one or more clinical symptoms that could be associated with CanL. ...
... CVL in Turkey was first reported in 1951 in Istanbul and Bursa [89] and, according to Toz et al. [90], it is a common disease throughout the country, being mainly caused by L. infantum. Recently, in a study conducted by Koenhemsi et al. [91] in Istanbul, 5/171 (2.92%) dogs of different breeds and ages tested positive for CVL. ...
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... They have been used in mapping and forecasting the epidemiology of prevalent diseases in a study area with high probability 7 . Environmental variables like normalized difference vegetation index (NDVI), enhanced vegetation index (EVI), digital elevation model (DEM), and emissivity (EMIS) have been used by many studies in Turkey to show the relationship between sandfly distribution and environmental factors effect [8][9][10][11][12] . ...
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... There are no recent reports of transfusion-transmitted malaria in Turkey. In a study conducted in 2012, only 2.97% of the 202 donors who were rejected due to the risk of malaria were found to be malaria positive (12). Plasmodium vivax, Plasmodium malariae, Plasmodium falciparum, and Plasmodium ovale in investigating the agents that cause transfusion-transmitted malaria globally were, until recently, reported as the agents, whereas the presence of transfusion-transmitted Plasmodium knowlesi was reported in recent years in endemic areas (13). ...
Reference: Nosocomial Parasitic Infections
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