January 1985
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23 Reads
·
916 Citations
Nature
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January 1985
·
23 Reads
·
916 Citations
Nature
... The α2-δ subunit acts as an auxiliary structure, playing a pivotal role in channel trafficking and modulation of channel kinetics, whereas the β auxiliary subunit significantly contributes to the regulation of channel gating properties. They are predominantly expressed in neuronal tissues [20], particularly enriched at presynaptic nerve terminals. Here, they facilitate the release of neurotransmitters by physically interacting with the synaptic release machinery [21]. ...
Reference:
A comprehensive review on Ziconotide
January 1985
Nature