M K Poddar's research while affiliated with Jadavpur University and other places

... In animal studies, treatment with carnosine decreases the AGEs level and oxidative stress in brain of d-galactose-induced aging changes in rats (Aydin et al., 2018). Carnosine supplementation increases the steady-state levels in the brain, improves dendritic spine density and cognitive impairment induced by aging, indicating that supplementation restores the antioxidative activity of endogenous carnosine and reduces neurodegeneration in rats (Banerjee et al., 2021). Carnosine also reduces the intraneuronal accumulation of Aβ and improves mitochondrial dysfunctions in AD mice (Corona et al., 2011). ...

... It is well known that Alzheimer 's disease (AD) is a neurodegenerative disease. The aggregation of extracellular amyloid plaques and formation of neurofibrillary tangles by hyperphosphorylated tau protein in neurons are the main neuropathological features closely related to central metabolic defects (1). Recent research has shown that the basic determinants of metabolism, such as a decline in brain glucose metabolism (2) and central insulin resistance, are the characteristics of AD intrinsic metabolic disorder (3), which is inextricably related to glucose metabolism and insulin sensitivity in the peripheral circulation (4,5). ...

... The traditional therapeutic approaches for AD, such as cholinesterase inhibitors (e.g., donepezil, rivastigmine, galantamine) and N-methyl-D-aspartate receptor (NMDAR) antagonist (memantine), are only used to provide symptomatic alleviation, but have no beneficial effects on the disease's course (Poddar et al. 2021;Lamptey et al. 2022). In recent years, the U.S. Food and Drug Administration (US FDA) has also approved several novel diseasemodifying drugs such as aducanumab and lecanemab (Dunn et al. 2021;Cummings et al. 2023), which act by lowering amyloid burden in AD patients (Lamptey et al. 2022;CH et al. 2023). ...

... Vitamin D reduced microglial pro-inflammatory cytokine and ROS production while inducing antiinflammatory cytokine expression in a Parkinson's disease animal model [24]. Likewise, L-carnosine significantly reduced amyloid-Beta (Aβ) deposition in the prefrontal cortex, hippocampus, and hypothalamus of aged rats, decreased serum corticosterone, and restored locomotor activity [25]. Polyphenols are well-characterized in aging studies and beneficial, tempering age-related decline. ...

... Platelet dysfunctions associated with aging can be linked to molecular alterations affecting several cellular systems that include cytoskeleton rearrangements, signal transduction, vesicular trafficking, and protein degradation. Aging in platelets and their age-dependent dysfunctions are of interest when evaluating the contribution of aging to the onset of aging-dependent pathologies, such as those affecting the nervous system linked to neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) [107,108]. ...

... 38 Carnosine neutralizes age-related neurodegenerative diseases and helps stabilize the nervous system by regulating the neurotransmitter system. 39 Therefore, 17β-estradiol supplementation appears to enhance β-alanine activity, suggesting potential benefits for muscle and nervous system health. β-Alanine is produced from aspartic and fumaric acid. ...

... These oligomers usually consist of a limited number of subunits (NS), ranging from two to ten, offering substantial combinatorial potential, particularly through both hetero-oligomerization and homo-oligomerization [5]. Furthermore, it is wellestablished that homo-oligomers play crucial roles in mediating and regulating processes such as gene expression [6], enzyme function [7], ion channels [8], receptors [9], and cell-cell adhesion [10]. Therefore, understanding the homo-oligomers is vital at the molecular level to comprehend the physiological functions of proteins and design molecular regulators for their modulation [11]. ...

... 11 Moreover, it has been reported that CR diets improve the agingrelated dysregulation of brain regional gamma-aminobutyric acid (GABA) system, corticosterone status, and cognitive function. 12 Nevertheless, the impact of CR or STF on spatiotemporal brain metabolome has been studied inadequately, only concentrating on limited metabolites or restricting to a few anatomical brain regions. 7,8 Using gas chromatography-mass spectrometry (GC-MS)-based metabolomics and liquid chromatography-mass spectrometry (LC-MS)-based lipidomics techniques, the present study profiled the metabolic signatures of seven brain regions and delineated metabolic remodeling across different brain regions following various periods of fasting. ...

... Interestingly, higher concentration of aldrin (6 mg/L) showed the down-regulation of superoxide dismutase gene in kidney and brain tissue. It indicates the reverse action that aldrin cause tolerance at optimum concentration 27,28 . The positive correlation of elevated SOD and up regulation of gene get supported by Hansen et al., as it is reported that in case of environmental toxicant there is positive correlation between enzyme activity and gene expression pattern. ...

... As for locomotor activity, we found that chlordane increased it while CPO had a dose-dependent effect, with higher locomotion at lower doses, a result in agreement with the literature (Gómez-Giménez et al. 2018). The hyperlocomotive effects of organochlorine pesticides have been directly associated with their acute inhibitory action on GABA transmission (Jamaluddin and Poddar, 2001), including those of chlordane (Al-Hachim and Al-Baker 1973;Cassidy et al. 1994). Interestingly, we found that chronic exposure to low concentrations of CPO increased basal GABA A R-mediated synaptic responses. ...