Luisa P Wallace's research while affiliated with Magee-Womens Hospital and other places
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Publications (25)
Background Digital breast tomosynthesis (DBT) is often inadequate for screening women with a personal history of breast cancer (PHBC). The ongoing prospective Tomosynthesis or Contrast-Enhanced Mammography, or TOCEM, trial includes three annual screenings with both DBT and contrast-enhanced mammography (CEM). Purpose To perform interim assessment o...
Performance changes in a binary environment when using additional information is affected only when changes in recommendations are made due to the additional information in question. In a recent study, we have shown that, contrary to general expectation, introducing prior examinations improved recall rates, but not sensitivity. In this study, we as...
Purpose:
To assess the effect of and interaction between the availability of prior images and digital breast tomosynthesis (DBT) images in decisions to recall women during mammogram interpretation.
Materials and methods:
Verbal informed consent was obtained for this HIPAA-compliant institutional review board-approved protocol. Eight radiologists...
Purpose:
To assess interpretation performance and radiation dose when two-dimensional synthesized mammography (SM) images versus standard full-field digital mammography (FFDM) images are used alone or in combination with digital breast tomosynthesis images.
Materials and methods:
A fully crossed, mode-balanced multicase (n = 123), multireader (n...
PURPOSE
To assess the diagnostic performance of combination synthetic mammograms and tomosynthesis (synthetic 2D+Tomo) to combination FFDM and tomosynthesis (FFDM+Tomo)
METHOD AND MATERIALS
IRB approval was obtained. 123 cases deemed challenging by 2 non-participating independent reviewers were chosen from our research database to create a stress...
PURPOSE
To compare the diagnostic performance of contrast enhanced cone beam computed tomography (CBCT) to dynamic contrast enhanced breast MRI in classifying breast lesions as benign or malignant, and to perform a subjective comparative quality assessment of the two modalities.
METHOD AND MATERIALS
Retrospective analysis of CBCT and MRI images ob...
The aim of this study was to retrospectively compare the interpretive performance of synthetically reconstructed two-dimensional images in combination with digital breast tomosynthesis (DBT) versus full-field digital mammography (FFDM) plus DBT.
Ten radiologists trained in reading tomosynthesis examinations interpreted retrospectively, under two mo...
To investigate consistency of the orders of performance levels when interpreting mammograms under three different reading paradigms.
We performed a retrospective observer study in which nine experienced radiologists rated an enriched set of mammography examinations that they personally had read in the clinic ("individualized") mixed with a set that...
The authors investigated radiologists, performances during retrospective interpretation of screening mammograms when using a binary decision whether to recall a woman for additional procedures or not and compared it with their receiver operating characteristic (ROC) type performance curves using a semi-continuous rating scale. Under an Institutiona...
To compare radiologists' performance during interpretation of screening mammograms in the clinic with their performance when reading the same mammograms in a retrospective laboratory study.
This study was conducted under an institutional review board-approved, HIPAA-compliant protocol; the need for informed consent was waived. Nine experienced radi...
Experts may agree in most decisions that they make when they read a case set of digital mammograms, but eye-position tracking
studies suggest that they use very different visual search strategies to make such decisions. If indeed each expert uses a
unique strategy, it may be very difficult to teach radiology trainees effective ways to search the ba...
This paper describes a high-quality, multisite telemammography system to enable "almost real-time" remote patient management while the patient remains in the clinic. One goal is to reduce the number of women who would physically need to return to the clinic for additional imaging procedures (termed "recall") to supplement "routine" imaging of scree...
In this study, we developed and tested a new multiview-based computer-aided detection (CAD) scheme that aims to maintain the same case-based sensitivity level as a single-image-based scheme while substantially increasing the number of masses being detected on both ipsilateral views. An image database of 450 four-view examinations (1800 images) was...
Although computer-aided detection (CAD) systems were designed and approved for and are assumed to be used as a "second-reader", namely radiologists are expected to interpret mammograms and detect suspected abnormalities (i.e., micro-calcification clusters and masses) independently before viewing CAD results, it is not clear whether radiologists in...
To retrospectively evaluate whether recall, biopsy, and positive biopsy rates for a group of radiologists who met requirements of Mammography Quality Standards Act of 1992 (MQSA) demonstrated any change over time during a 27-month period (nine consecutive calendar quarters).
Institutional review board approved study protocol, and informed consent w...
Eight radiologists interpreted 110 subtle cases in an observer performance study. The database includes 51 verified masses and 44 microcalcification clusters. Of these, 35 masses and 29 clusters were associated with malignancy. Two computer-aided detection (CAD) cueing conditions involving the same case-based sensitivity of 73% and two false-positi...
This study was designed to evaluate radiologists" ability to identify highly-compressed, digitized mammographic images displayed on high-resolution, monitors. Mammography films were digitized at 50 micron pixel dimensions using a high-resolution laser film digitizer. Image data were compressed using the irreversible (lossy), wavelet-based JPEG 2000...
The authors investigated the correlation between recall and detection rates in a group of 10 radiologists who had read a high volume of screening mammograms in an academic institution.
Practice-related and outcome-related databases of verified cases were used to compute recall rates and tumor detection rates for a group of 10 Mammography Quality St...
The authors evaluated the impact of different computer-aided detection (CAD) cueing conditions on radiologists' performance levels in detecting and classifying masses depicted on mammograms.
In an observer performance study, eight radiologists interpreted 110 subtle cases six times under different display conditions to detect depicted masses and cl...
Computer-aided mammography is rapidly gaining clinical acceptance, but few data demonstrate its actual benefit in the clinical environment. We assessed changes in mammography recall and cancer detection rates after the introduction of a computer-aided detection system into a clinical radiology practice in an academic setting.
We used verified pract...
We evaluated a telemammography system for reviewing and rating screening mammography in a clinical setting. Three remote sites transmitted 306 exams to a central site. Films were digitized at 50 micron pixel dimensions and compressed at a 50:1 ratio. At the central site images were displayed on a workstation with two high-resolution monitors. Five...
We evaluated a telemammography system for reviewing and rating screening mammography in a clinical setting. Three remote sites transmitted 306 exams to a central site. Films were digitized at 50 micron pixel dimensions and compressed at a 50:1 ratio. At the central site images were displayed on a workstation with two high-resolution monitors. Five...
We investigated a new approach to improve the performance of a computer-aided detection (CAD) scheme in identifying masses depicted on images acquired earlier ("prior"). The scheme was trained using a dataset with simulated mass features. From a database with images acquired during two consecutive examinations, 100 locations matched pairs of malign...
Breast tissue density is one of the most cited risk factors in breast cancer development. Nevertheless, estimates of the magnitude of breast cancer risk associated with density vary substantially because of the inadequacy of methods used in tissue density assessment (e.g., subjective and/or qualitative assessment) and lack of a reliable gold standa...
The authors assessed and compared the performance of a computer-aided detection (CAD) scheme for the detection of masses and microcalcification clusters on a set of images collected from two consecutive ("current" and "prior") mammographic examinations.
A previously developed CAD scheme was used to assess two consecutive screening mammograms from 2...
Citations
... Recently, the performance of deep learning and Convolutional Neural Network (CNN) algorithms in image classification has significantly improved, as has the detection of lesions by mammography and the evaluation of image quality [4]. A variety of methodologies have been used to increase the accuracy of deep CNNs [5,6]. ...
... Together with the DBT image, most vendors also offer a synthetic mammography image: a 2D image created from the projections and/or reconstructions of the DBT image. The added value of this image has been evaluated in multiple studies [1][2][3][4]. This synthetic mammography (SM) image serves as a 2D visualization of the DBT volume and as an overview of the breast. ...
... -We analyzed breast tissue composition from 2D mammographic data, despite tissue compression, by using computerized algorithms we have previously developed and reported [1][2][3]. Digitized mammograms were used for this study. The breast region was manually segmented from remainder of the image. ...
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... Many researchers believe that high false-positive detections reduce the specificity of radiologists in reading mammograms and thus, reduces the overall performance of radiologists as evaluated based on the areas under ROC curves. As a result, many radiologists choose to ignore CAD-cued suspicious regions, in particular, the mass-type regions [3]. However, whether the CAD-generated false-positives are totally harmful or whether CAD-generated false-positives can provide any potentially valuable information or imaging markers to assist in improving the efficacy of breast cancer screening has not been investigated to date. ...
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... Processed image data may alter the effectiveness of the mammography CAD algorithms if processing effects are not taken into account. 4. The mammography CAD prompt may influence performance [56][57][58]. ...
... In [Mello-Thoms et al. 2008] six radiologists were involved in exploring and marking benign and malignant masses in two-view mammograms. For this research purpose, such eye tracking metrics were used as: time to first fixation on the first diagnosed area, total amount of time spent at a given location and the number of fixations in an area of a given diagnosed area. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272446662115353-1441967754567_Q64/Claudia-Mello-Thoms.jpg)
... Digital breast tomosynthesis (DBT) detects more breast cancers than 2D digital mammography (2DM) [1,2]. However, 2DM remains more sensitive than DBT alone for calcifications, and 2DM and DBT have historically been performed together [3,4]. In practice, when indeterminate calcifications are detected on mammography, the patient is called back for additional views using 2D magnification for additional characterization. ...
... Different sizes of acceptance radius have an impact on the figure of merit (FOM) calculated at analysis, therefore showing a different measure of observer performance. Less strict radii can lead to an inflated FOM (27). The size of the acceptance radius should be a careful consideration in study design, with a significant effect on the classification of mark-rating pairs as either lesion or nonlesion localization (25). ...
... The confidence scores, which indicated the reader's confidence in the presence of an abnormality, were collected for analyzing the readers' performance in an experimental setting using the receiver operating characteristic curve (ROC). Previous works [9] on analyzing binary and continuous/multi-category ratings in mammography observer studies have demonstrated that these two decision-making processes yield similar reader performances even though the binary true positive fraction (TPF) and false-positive fraction (FPF) operating points do not always lie on the ROC curves but in their vicinity. ...
... The test set was read outside normal clinical practice and therefore reader performance is likely to have been subject to a laboratory effect [37]. ...
