Liyu Yang's research while affiliated with ShenJing Hospital of China Medical University and other places

... Some studies have identified several genes associated with OS ferroptosis by bioinformatics analysis, which may provide research directions for this purpose (Figure 3). [171][172][173][174][175] Conclusion As a novel CFD, ferroptosis is tightly regulated at different levels and is involved in the pathogenesis of many diseases. Since its discovery in 2012, ferroptosis has been increasingly investigated in bone-related diseases. ...

... DCs regulate the activation and polarization of effector T helper cells and regulatory T cells, serving as key modulators of immunity and tolerance [30]. Mature DCs undergo metabolic and phenotypic changes, including the secretion of various cytokines like interleukins (IL) 1β, IL-6, IL-12, or tumor necrosis factor TNF-α, and upregulation of dermatitis but also lay a significant foundation for its future clinical application and drug development [35,36]. ...

... Irisin is primarily produced by skeletal muscles; however, it has also been reported that it can be secreted by adipose tissue and in smaller amounts by the testes, liver, pancreas, brain, spleen, heart, and stomach [26]. It has been shown that irisin is expressed in response to exercise as well as cold-induced muscle shivering [27,28]. However, the most effective training protocol for increasing irisin levels has not yet been established. ...

... 7 Most circRNAs are highly expressed in OS, and carcinogenic circRNAs can accelerate OS progression, the carcinogenic ability of circRNA is mainly reflected in promoting cell proliferation and metastasis and affecting apoptosis. 8 Circ-0001658 promotes proliferation and metastasis and blocks apoptosis in OS cells by sponging miR-382-5p and regulating the expression of YB-1. 9 According to Wu et al., circTADA2A overexpression promotes metastasis in OS by sponging miR-203a-3p. 10 CircORC2 is a relatively new circRNA, and recent studies have shown that it is generally upregulated in OS cell lines, promoting OS cell growth and invasion by regulating the miR-19a/PTEN axis. ...

... LNC_000052 and PIK3R1 shared a common miRNA target, miR-96-5p, whose downregulation could restrain the effects of LNC_000052 knockdown. 181 In another study on osteoporosis, PTEN could inhibit the activation of downstream proteins in Akt signaling. Moreover, lncRNA MIR22HG could downregulate PTEN, thus promoting osteogenic differentiation by activating Akt signaling. ...

... Osteoporosis (OP) is a bone condition marked by bone mass reduction, weakened bone microarchitecture and quality, leading to hindered strength and increased risks of fracture [1,2]. The disease also has socio-economic effects with prevalence of approximately 6.6% in men and 22.1% in women above 50 years [3,4]. Fundamental interactions of osteoclasts and osteoblasts regulate bone metabolism. ...

... 79 Leonurine hydrochloride, a synthetic chemical compound with antioxidant and antiapoptotic activities derived from leonurine, was shown to promote phosphorylation of GSK-3β to enhance the activity of β-catenin, thereby accelerating bone formation. 80 Similarly, OB differentiation was increased by stimulating the Wnt/β-catenin signaling pathway via treatment piperine treatment, resulting in elevated bone mineral density in OVX mice. 81 In addition to alkaloid-SMAs, many endogenous SMAs (e.g., adenosine, Gln, taurine, glucosamine, and Sphingosine-1-phosphate) facilitated bone formation through the Wnt pathway. ...

... In addition, (−)-epicatechin gallate stimulates osteoblast differentiation by activating the PDZ-binding motif (TAZ) and RUNX2 (44). EGCG has antioxidant effects via the Nrf2 pathway, thereby protecting osteoblasts from apoptosis and attenuating bone microstructure deterioration (45). Theaflavin-3,3′-digallate activates several signaling pathways, including the tumor necrosis factor-α (TNF-α)-inhibited mitogen-activated protein kinase (MAPK), Wnt/βcatenin, and BMP/Smad pathways. ...

... There is growing evidence that shows how DEX-induced oxidative stress contributes to osteoporosis [32,36,37]. Several in vitro studies reported that DEX may cause osteoblast dysfunction with consequent bone loss [38,39]. Liu S. et al. showed that DEX-treated osteoblasts exhibited lower mRNA levels of osteogenic genes, such as Runx2, osterix, bone morphogenetic protein-2, and osteocalcin. ...

... Gastrodin is extracted from the dried tubers of gastrodia elata, a Chinese herb, which has antioxidant, anti-inflammatory and antiapoptosis effects [13]. Its main active ingredient is 4-hydroxybenzyl alcohol-4-O-β-D-glucopyranoside, with the molecular formula C13H18O7 and a molecular weight of 286 Da. ...