Liuling Guo's research while affiliated with Tongji University and other places
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Publications (10)
Background
Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including antioxidative, anti-inflammatory, anticancer, neuroprotective and senescent cell-clearing activities. It has been shown to effectively alleviate neurodegenerative diseases and enhance cognitive functions in various models...
Background: Immunosenescence accelerates systemic aging and influences cognitive function, with antioxidants potentially mitigating these effects. The significance of ascorbic acid (vitamin C) as a crucial antioxidant in anti-aging and cognition, as well as the potential impact of the gut microbiome on this process, has yet to be investigated.
Resu...
Background: Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including antioxidative, anti-inflammatory, anticancer, neuroprotective and senescent cell-clearing activities. It has been shown to effectively alleviate neurodegenerative diseases and enhance cognitive functions in various model...
Background
Glycyrrhizic acid (GA), a saponin compound often used as a flavoring agent, can elicit anti-inflammatory and anti-tumor effects, and alleviate aging. However, the specific mechanism by which GA alters immune cell populations to produce these beneficial effects is currently unclear.
Results
In this study, we systematically analyzed singl...
Nicotinamide adenine dinucleotide (NAD⁺) is crucial for energy metabolism, oxidative stress, DNA damage repair, longevity regulation, and several signaling processes. To date, several NAD⁺ synthesis pathways have been found in microbiota and mammals, but the potential relationship between gut microbiota and their hosts in regulating NAD⁺ homeostasi...
Background: Glycyrrhizic acid (GA), a saponin compound often used as a flavoring, can elicit anti-inflammatory and anti-tumor effects, and alleviate aging. However, the specific mechanism by which GA alters immune cell populations to produce these beneficial effects is currently unclear.
Results: In this study, we systematically analyzed single-cel...
Traditional pathological diagnoses and clinical methods are insufficient to accurately predict the prognosis of lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) process is closely related to tumor cell migration. However, the prognostic value of EMT-related genes in LUAD is still unclear. In this study, we collected bulk RNA-sequ...
Nicotinamide adenine dinucleotide (NAD ⁺ ) is crucial for energy metabolism, oxidative stress, DNA damage repair, longevity regulation, and several signaling processes. To date, three NAD ⁺ synthesis pathways have been found in microbiota and hosts, but the potential relationship between gut microbiota and their hosts in regulating NAD ⁺ homeostasi...
Traditional pathological diagnoses and clinical methods are insufficient to accurately predict the prognosis of lung adenocarcinoma (LUAD). Epithelial-mesenchymal transition (EMT) process is closely related to tumor cell migration. However, the prognostic value of EMT-related genes in LUAD is still unclear. In this study, we collected bulk RNA-sequ...
Citations
... As mice age, the quantity and functions of immune cells undergo changes. Our previous studies demonstrated an association between immune cells and cognitive function [33,34]. Therefore, we examined the immune cell population in the spleen after quercetin treatment. ...
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... RNA sequencing (RNA-seq) As previously stated [33], total RNA was extracted from the samples for the purpose of constructing an RNA-seq library, which was subsequently sequenced and analyzed using the BGIseq500 platform (BGI, Shenzhen, China). The initial sequencing reads underwent puri cation by removing those containing adaptors or poly-N sequences, as well as reads with a high proportion of low-quality bases. ...
... More speci cally, EMT encourages tumor cells to separate from their original site and to move into the bloodstream, where they eventually colonize secondary organs (Qu et al. 2023). Several studies have indicated that EMT-related genes (ERGs) can be used as markers for predicting the prognosis of LUAD patients (Cui et al. 2022; (Feng et al. 2022). Ferroptosis, a relatively recent discovery in the domain of programmed cell death, is distinguished by notable iron accumulation and lipid peroxidation in the course of the cell demise process, setting it apart from the mechanisms of apoptosis, necrosis, and autophagy . ...
... This indicating that NAD synthesis by the deamidated biosynthesis pathway is an extremely ancient evolutionary process, present in all biological kingdoms (Gazzaniga et al., 2009). Many members of the bacterial genera of mammalian microbiota harbor the PncA protein, including Escherichia, Klebsiella, Salmonella, Fusobacterium, Enterococcus, Bifidobacterium, Lactobacillus, Clostridium (but apparently not Clostridioides) or Prevotella; within the phylum Bacteroidetes, PncA is rare among Bacteroides (Feng et al., 2021). In fact, if mice are treated with the PncA inhibitor pyrazinecarbonitrile, an analog of pyrazinamide (an anti-tuberculosis drug), the abundance of Clostridiales in the microbiota significantly decrease, showing its dependence on NAD deamidation synthesis. ...
