Ling-Ling Zhang's research while affiliated with Harbin Medical University and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (12)
ADP-glucose pyrophosphorylase (AGP) consists of two large (AGP-L) and two small (AGP-S) subunits; it regulates the limiting step in the biosynthesis of starch. Here, we isolated the full-length cDNA sequence of the AGP-S gene (designed as Agp1) from wheat and whole genomic sequences from relatives of wheat. The coding region of Agp1 ranged from 594...
At present, all electrospraying processes are conducted in air environment without considering the importance of electrohydrodynamic interfaces, thereby preventing the development of new possibilities. In this study, a modified coaxial electrospraying process for preparing multicomponent composite nanoparticles was investigated, in which solvents w...
Hypromellose (HPMC)-based hydrophilic composites (HCs) used for rapid dissolution of ferulic acid (FA) were investigated. Electrospun and casting HCs were prepared from a solution containing HPMC, FA, and polyethylene glycol. Ethanol was used as sheath fluid during coaxial processes, and the effects of its flow rates on the Taylor cone and straight...
Key message:
A novel Wx-B1 allele was characterized; a transposon insertion resulted in the loss of its function, which is different from the previously reported gene silencing mechanisms at the Wx-B1 locus. The waxy protein composition of 53 Chinese wheat landraces was analyzed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-...
The promyelocytic leukemia protein (PML) is essential in the assembly of dynamic subnuclear structures called PML nuclear bodies (PML-NBs), which are involved in regulating diverse cellular functions. However, the possibility of PML being involved in cardiac disease has not been examined. In mice undergoing transverse aortic constriction (TAC) and...
In this study, we designed and constructed a super twin T-DNA vector (pTRIDT313-g) containing two independent T-DNA cassettes―one for the selection gene Hyg and the other for the target gene Gus―to produce marker-free transgenic lines. The resulting vector was transformed into tobacco, and polymerase chain reaction (PCR) analysis showed four types...
The role of type III transforming growth factor-β receptor (TβRIII) in the pathogenesis of heart diseases remains largely unclear. Here, we investigated the functional role and molecular mechanisms of TβRIII in the development of myocardial hypertrophy. Western blot and quantitative real time-polymerase chain reaction analyses revealed that the exp...
ADP-glucose pyrophosphorylase (AGP), which consists of two large subunits (AGP-L) and two small subunits (AGP-S), controls the rate-limiting step in the starch biosynthetic pathway. In this study, a full-length open reading frame (ORF) of AGP-L gene (named as Agp2) in wheat and a series of Agp2 gene sequences in wheat relatives were isolated. The c...
Aegilops sharonensis is a diploid relative of wheat and has novel high molecular weight glutenin subunits (HMW-GSs) encoded by Glu-1S
sh
. Hybrids of tetraploid wheat species and Ae. sharonensis have been successfully created by wild crosses. In our study, we conducted backcrosses and introduced the novel HMW-GSs of Ae. sharonensis into hexaploid w...
Starch-branching enzyme I (SBE I) belongs to a member of SBEs isoforms,which plays an important role in amylopectin biosynthesis. In this study, we measured starch content, determined SBE activity within endosperms, analyzed expression patterns of SBE I by real-time quantitative PCR(RT-qPCR), and characterized sequences of SBE I from two accessions...
Citations
... Wheat grain has AGPase present both in the cytoplasm and in the amyloplast, however the cytosolic isoform accounts for >90% of activity (Burton et al. 2002;Emes et al. 2003;Tetlow and Emes 2017). Evidence suggests that different genes encode the large and small subunits present in the cytosol and the amyloplast in wheat endosperm (Burton et al. 2002;Zhang et al. 2017b). AGPase is commonly found to be allosterically regulated, with activation by 3 phosphoglyceric acid (3PGA) and inhibition by inorganic phosphate (Pi) (Preiss et al. 1991). ...
... Electrospinning is one of many techniques, which promotes the development of freestanding networks composed of nano-sized fibrous structures. By increasing the water solubility of drug molecules, Electrospun nanofiber webs of hydrophilic polymers can even be polymerized with a wide range of drugs and used as a fast-acting mouth delivery mechanism 47,48 . Polyvinylpyrrolidone (PVP), poly (vinyl alcohol) (PVA), gelatin, eudragit, as well as other polymers are used to make fast-dissolving DDS in the form of nanostructured materials. ...
Reference: Nanofibers in Drug Delivery System
![[object Object]](https://i1.rgstatic.net/ii/profile.image/858376175108098-1581664236047_Q64/Yaoyao-Yang.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/901595206266881-1591968456648_Q64/Deng-Yu-2.jpg)
... This finding suggested that the addition of vesicles, high porosity, smaller diameter, hy dr ophilicity, and other architectural and component properties could not significantly influence the solubility of the material being composited . How ev er, sw elling index results tended to impr ov e in w a ter absorption capacity for the test scaffold , compar ed with the control scaffold due to reduced pores size that could retain w a ter molecules after absorption and crosslinking efficacy between polymers vesicular suspension enhancing the gelation behavior of HPMC [ 52 ]. The results directed a considerably r educed por osity of the scaffold invigorated with VCUR/VTHC. ...
... The relationship between natural variation in genes related to starch synthesis and its properties has been better established in other species. Transposable elements, insertions and deletions of different lengths, and single nucleotide polymorphisms (SNPs) are correlated to the waxy phenotype in such plant species as rice (Larkin and Park 2003;Kharabian-Masouleh et al. 2012), maize (Xiaoyang et al. 2017), and wheat (Saito and Nakamura 2005;Monari et al. 2005;Zhang et al. 2017). In addition, in crops such as wheat and rice, the dose effect of each allelic form has already been characterized between partial and complete waxy mutants (Yamamori and Quynh 2000;Dobo et al. 2010). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/411229345599490-1475056124916_Q64/Qiantao-Jiang.jpg)
... Several mutations arise from the insertion of transposable elements into this gene. The molecular genetics of the GBSS I gene have also been studied in rice [54][55][56][57][58], barley [59][60][61], sorghum [62][63][64][65], Job's tears [66], maize [67][68][69][70][71][72], and common millet [73]. In rice and barley, waxy landraces show a monophyletic origin [57,58], whereas the waxy landraces of sorghum [62][63][64][65], Job's tears [66], maize [67][68][69][70][71][72], and common millet [73] originated polyphyletically. ...
Reference: Crop Evolution of Foxtail Millet
... Cardiac fibrosis is a common feature of end-stage heart diseases, such as diabetic cardiomyopathy (DCM), myocardial infarction (MI), and hypertrophic cardiomyopathy. Pin1, acting as a positive regulator of TGF-β1, colocalizes with promyelocytic leukemia protein (PML) and is involved in the TGF-β1/PML SUMOylation/Pin1 loop, all of which are upregulated in cardiac fibrosis (Liu et al., 2017;Wu et al., 2019). Pin1 inhibitors, such as Juglone, ginkgolic acid (inhibiting SUMO-1), miR-34a overexpression, and loureirin B, have been shown to alleviate cardiac fibrosis by reducing Pin1 expression and recruitment Zhang et al., 2021). ...
... The reaction products were then used directly for E. coli transformation, and positive clones were selected and analyzed by sequencing. The genome editing vectors constructed were introduced into Agrobacterium tumefaciens strain AGL 1 competent cells as described in our previous study (Yang et al., 2016). PCR amplification was performed to screen for the clones containing the genome editing fragments with F 1 and R 1 primers (Supplementary Table 1) targeted to the gRNA target site regions in the T-DNA of genome editing vector, and the recombinant Agrobacterium cells were employed for barley transformation. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1129716417331200-1646356791135_Q64/Qiang-Yang-39.jpg)
... In mice, carvedilol improves cardiac function via β-arrestin2 52 . Isoproterenol, on the other hand, worsens cardiac dysfunction in a β-arrestin2-dependent manner 53 . These reports indicate that pharmacologically distinct ligands elicit different β-arrestindependent responses by preferentially utilizing specific GRKs. ...
... Overexpression of the wheat AGP-L gene has improved AGPase activity by more than 1.5-fold, and grain weight has been observed to increase in some transgenic plant lines [7]. Variations in the sequence of the AGP-L gene in the B subgenome (TaAGP.L-B1) are more abundant than those in the other two subgenomes [8,9], and the SNPs of TaAGP.L-B1 in the natural population result in variation in thousand grain weight and seed number, but no significant variation is observed in total starch content [9]; however, the mutant line E3-1-3 carrying the missense mutation of TaAGP.L-B1 shows a marked decline in total starch content [10]. ...
... sharonensis novel alleles (characterized by subunits 1S sh x2.3 and 1S sh y2.9) into common wheat using wild crossing procedures, and generated 18 stable introgression lines by continuous backcrossing and selfcrossing. 16,[18][19][20] The objective of this study was to analyze the effects of Ae. sharonensis HMW-GS on processing and end-use quality traits of common wheat and discuss the role of Glu-1S sh in wheat quality improvement. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/748628805156866-1555498424750_Q64/Long-Wei-4.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/429214101970946-1479344024891_Q64/Jian-Ma-12.jpg)
