Lina Lu's research while affiliated with Shanghai Jiao Tong University and other places

... It is one of the older tertiary general hospitals in Shanghai and the only general hospital in Shanghai that has both perinatal and complete pediatric subspecialties [83,84]. As a general hospital encompassing pediatrics, Xinhua Hospital has established a good reputation in Shanghai and even throughout China [70,[85][86][87]. However, the current medical services of the Pediatric Outpatient Clinic of Xinhua Hospital is no longer sufficient to cope with the increase in the hospital's business volume and cannot continue to provide high-quality medical services for children. ...

... Visceral myopathies (VMs), including chronic intestinal pseudoobstruction, pediatric-onset intestinal pseudo-obstruction, and megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS), are a group of rare diseases that often cause death in childhood (1)(2)(3). VM arises from smooth muscle dysfunction in the bowel, bladder, and uterus (1). The most common cause of VM is mutations in the gene encoding smooth muscle γactin (ACTG2) (4,5). ...

... It is even more difficult to define IFALD prevalence in the various subgroups of patients according to IF etiology. IFALD occurs in 20%−60% of pediatric patients receiving prolonged PN and manifests as cholestasis in 25%−60% of cases (3,(6)(7)(8)(9)(10). In neonatal population, the rates are increased, particularly in patients with necrotizing enterocolitis (NEC). ...

... It is characterized by focal or diffuse dilatation of bowel lymphatics [2][3][4] in the lamina propria region of the villi, often extending into the submucosa [5] . The global prevalence and incidence of primary intestinal lymphangiectasia (PIL) are still unknown [3,6,7] . It was first reported by Waldmann et al. in 1961 [6] . ...

... There are a variety of reasons that can cause a volvulus to develop including anatomically variations, medications, lifestyle, changes in physiology [2]. Some patients undergoing surgical treatment after intestinal necrosis will also develop short bowel syndrome due to excessive bowel resection, leading to poor prognosis [3]. Therefore, early diagnosis and treatment of intestinal volvulus is very important. ...

... Preschool children have heightened nutritional needs due to their rapid growth, and malnutrition during this phase can have lasting developmental repercussions, including delays in development, psychomotor deceleration, and behavioral disorders [14,15]. Insufficient dietary patterns, including selective eating or insufficient feeding practices by caregivers, can result in the overconsumption of certain foods and imbalanced diets, leading to overweightness and inadequate intake of trace elements [16][17][18][19][20]. Picky eating behaviors are characterized by the refusal to eat certain foods, neophobia, and other irregular eating habits [21]. ...

... Most of the variation in MMIHS cases is a heterozygous missense mutation in the ACTG2 gene, reported in many patients with autosomal dominant. [6][7][8][9][10][11] ACTG2 encodes for one of the six actin isoforms (gamma-2 smooth muscle actin) and is mainly expressed in urinary bladder and intestinal tissues. The other four genes have recently been reported in a few patients with MMIHS. ...

... [2] They require chronic parenteral nutrition as well as gradual oral feeding with hypo osmolar preparations to enhance absorptive capacity and achieve autonomy. [3] Some studies using hormonal modulation have also yielded promising results. [1,3] Our country still lacks specialized centers that explain the poor prognosis in our cases. ...

... Previous studies have suggested that total parenteral nutrition (TPN) leads to a significant loss of microbial diversity and alterations in the gut microbial profile in animals and infants [4,5]. Probiotic bacteria such as Lactobacillus and Bifidobacterium are commonly used in the treatment of gastrointestinal diseases such as inflammatory bowel disease, necrotizing enterocolitis, and short bowel syndrome (SBS) with controversial results [6]. ...

... A retrospective study of risk factors associated with PNAC in preterm infants showed that birth weight and gestational age at birth were not independent risk factors for PNAC in preterm infants (P were 0.219 and 0.998, respectively) [22]. Another study of 387 infants examining risk factors for PNAC in VLBWI also showed that birth weight and gestational age at birth were not independent risk factors for the development of PNAC (P 0.773 and 0.181, respectively) [23], which is consistent with the results of this study. However, lower gestational age at birth and lower birth weight were associated with a higher incidence of early complications in preterm infants, which tend to have more severe symptoms and inevitably lead to a longer hospital stay. ...