Lilith Trassl's research while affiliated with Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) and other places
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Publications (5)
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Background
Lung squamous carcinoma (LUSC) is a major lung cancer killer with no biomarkers and limited therapeutic options. Although still unclear, transformation of the pseudostratified and basal epithelium is linked with its origin.
Materials and Methods
With integrated transcriptomics, proteomics, genomics, epigenetics, and single-cell RNA sequ...
Malignant pleural mesothelioma (MPM) is a rare, incurable cancer of the mesothelial cells lining the lungs and the chest wall that is mainly caused by asbestos inhalation. The molecular mechanisms of mesothelial carcinogenesis are still unclear despite comprehensive studies of the mutational landscape of MPM, and the most frequently mutated genes B...
Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural cavity of asbestos-exposed individuals and rapidly leads to death. MPM harbors loss-of-function mutations in BAP1, NF2, CDKN2A, and TP53, but isolated deletion of these genes alone in mice does not cause MPM and mouse models of the disease are sparse. Here, we sho...
Citations
... As previously reported, 1-2% of patients with PM or PeM may have a potentially actionable KRAS mutation and thus could be treated with specific KRAS inhibitors. Furthermore, high throughput screening methods and preclinical models indicate KRAS as a potentially actionable mutation, at least in PM patients [70,71]. ...
... On the other hand, mutant KRAS extends to activate the apoptotic MST2-LATS1 serine/threonine-protein kinase 3/STK3-LATS1 pathway by binding to the tumor suppressor RASSF1A (Ras association domaincontaining protein 1) 77 , which is closely related to the Hippo pathway. Notably, NF2 and KRAS are mutually exclusive, indicating that these genes interact to participate in mesothelioma tumorigenesis 78 . However, further investigations are needed to determine whether these two factors synergize to promote tumor cell proliferation. ...
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