Lijuan Sun's research while affiliated with Capital Medical University and other places

Publications (20)

Article
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Background Frontonasal dysplasia (FND) is a rare congenital anomaly resulting from the underdevelopment of the frontonasal process, and it can be syndromic or nonsyndromic. The typical features of FND include a deformed nose and ocular hypertelorism, which are sometimes associated with cleft lip and/or palate. Only approximately 10 cases of prenata...
Article
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Background Left–right laterality disorders are a heterogeneous group of disorders caused by an altered position or orientation of the thoracic and intra-abdominal organs and vasculature across the left–right axis. They mainly include situs inversus and heterotaxy. Those disorders are complicated by cardiovascular abnormalities significantly more fr...
Article
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Objectives Little study has reported the association of maternal weight gain in early pregnancy with fetal congenital heart disease (CHD). We aimed to explore the potential relationship based on a China birth cohort while adjusting by multiple factors. Design Cohort study. Setting China birth cohort study conducted from 2017 to 2021. Participant...
Article
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(1) Background: There is no reliable way to assess antenatal fetal pulmonary hypoplasia; however, the biological parameters of the fetal lung can help in evaluating fetal lung development. This study aimed to establish the reference intervals for normal fetal lung biological parameters at 21–40 weeks among the Chinese population. (2) Methods: This...
Article
Background: Little evidence exists regarding the combined effect between ambient temperature and air pollution exposure on maternal blood pressure (BP) and hypertensive disorders of pregnancy (HDP). Objectives: To assess effect modification by temperature exposure on the PM1-BP/HDP associations among Chinese pregnant women based on a nationwide...
Article
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Background To evaluate the role of a standardized first-trimester scan in screening different kinds of central nervous system malformations and to report a 3-year experience from a tertiary center using an unselected cohort. Methods This was a retrospective analysis of prospectively collected data from a single center evaluating first-trimester sc...
Article
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Limited evidence exists regarding the association between ambient temperature and blood pressure (BP) level of pregnant women. To investigate the associations of ambient temperature with maternal BP and hypertensive disorders of pregnancy (HDP), we studied 105,063 participants in 38 centers of 17 provinces from November 2017 to December 2021. BP wa...
Article
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Abstract Background To establish the normal reference ranges for parameters related to the fetal posterior fossa in the first trimester (11 ~ 13+6 weeks of gestation) and to analyze the relationship between them and crown-rump length (CRL) among the Chinese population. Methods Singleton pregnancies of 11 ~ 13+6 weeks (CRL:45 ~ 84 mm) with both pare...
Preprint
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Background To establish the normal reference ranges for parameters related to the fetal posterior fossa in the first trimester (11 ~ 13+ 6 weeks of gestation) and to analyze the relationship between them and crown-rump length (CRL) among the Chinese population. Methods Singleton pregnancies of 11 ~ 13+ 6 weeks (CRL:45–84 mm) with both parents from...
Article
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Objectives The primary aim of this study was to establish the normal reference ranges of the fetal left ventricular (LV) Modified Myocardial Performance Index (Mod-MPI). A secondary aim was to evaluate the agreement between manual and automatic measurements for fetal Mod-MPI. Design A prospective, multicentre, cross-sectional study. Participants...
Article
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Objectives: To investigate fetal hemodynamic alterations using transabdominal ultrasound in fetuses with isolated mild-to-moderate ventriculomegaly (VM). Methods: Fetuses diagnosed with isolated mild-to-moderate VM by transabdominal ultrasound were evaluated for hemodynamic changes, including changes in fetal cardiac function, the umbilical arte...
Article
Objectives: To quantitatively assess prenatal diagnostic performance of three-dimensional ultrasound (3D-US) for posterior fossa anomalies (PFA), and establish a preliminarily 3D-US prediction model. Methods: Sixty singleton fetuses suspected of PFA by 2D-US presented their detailed 3D-US evaluation. The surface area of vermis (SAV), brainstem-v...
Article
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Aim To investigate the changes of modified myocardial performance index (Mod‐MPI) in early‐onset and late‐onset fetal growth restriction (FGR) cases, and its association with adverse perinatal outcome. Methods This was a prospective study on 77 early‐onset and 100 late‐onset FGR cases. Hundred normal fetuses were matched as control groups for earl...
Article
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Background This study investigated whether fetuses of placenta previa pregnancies have cardiac dysfunction by use of a modified myocardial performance index (Mod-MPI). Material/Methods A prospective cross-sectional study was conducted including 178 fetuses at 28–40 weeks of gestation. Eighty-nine fetuses of mothers with placenta previa and without...
Article
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Objectives: Imaging assessment of the female urethra is critical for diagnosis and treatment of urinary incontinence. High-frequency 3-dimensional (3D) transvaginal ultrasonography (TVUS) is a novel technique for evaluating the female urethra. The aim of this study was to test the repeatability of 3D TVUS between examiners without prior experience...
Article
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Background Congenital intracranial tumors as a group are quite rare, representing only 0.5% to 1.5% of all pediatric brain neoplasms. Case report We reported a case of congenital mixed neuronal-glial tumor detected by ultrasound at 30 weeks of gestation. It showed that the tumor was 2.5 × 2.3 × 2.1 cm³ in size, located in the sellar region, regula...
Article
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Introduction Urorectal septum malformation sequence (URSMS) is a rare congenital abnormal syndrome that is caused by the incomplete division of the cloaca. Based on whether the cloaca membrane breaks down or not, the URSMS are classified as full and partial forms. The prenatal diagnosis of URSMS remains challenging because of poor recognition to th...
Article
Full-text available
The aims of this study were to evaluate the contribution of chromosomal microarray analysis (CMA) in the prenatal diagnosis of fetuses with central nervous system (CNS) anomalies but normal chromosomal karyotype. A total of 46 fetuses with CNS anomalies with or without other ultrasound anomalies but normal karyotypes were evaluated by array-based c...
Article
The aims of our study were to evaluate the usefulness of array-based comparative genomic hybridization (aCGH) for prenatal genetic diagnosis of congenital heart disease (CHD), with and without associated anomalies, and to explore the relationship between submicroscopic chromosomal aberrations and CHD. Seventy-six consecutive singleton fetuses with...

Citations

... For normal first trimester ultrasound screening, the four fetal brain planes that make up the standardized anatomical procedure were advised. [20] In the comparative analysis between NSG and MRI, concordance and correctness were achieved in 86.5% of cases. MRI, requested for confirmation or additional anomalies, provided clinically relevant information in 7.9% of cases. ...
... At the same time, there is growing evidence that nonoptimal temperatures increase the risk of cardiovascular and perinatal diseases 6,27 . For example, recent studies on hypertensive disorders in pregnancy have shown that heat exposure at 1-20 weeks of gestation increases the odds of preeclampsia and gestational hypertension [28][29][30] . Moreover, the change in BP for pregnant women is a U shape; it falls first and then rises, and the 20th week of gestation is an inflection point 31 . ...
... One of the large-sample studies reporting the normal ranges of fetal mMPI is based on cross-sectional data from 730 women conducted in Spain [12]. Another study was conducted in China, involving 2,081 women with singleton pregnancies [13]. ...
... Termed the "brain sparing effect," this in-utero modulation of brain vascular resistance ensures cerebral perfusion is maintained [8]. Fetal ventriculomegaly, the most commonly identified abnormality of the fetal CNS, has been associated with elevated levels of mMPI [9]. ...
... On sagittal section of the fetal cerebellar vermis, it has a shape of orange petals. The integrity of the cerebellar vermis can be judged by morphologic observation (orange petals, primary fissure, and secondary fissure) [8]. In recent years, three-dimensional ultrasound has provided a new method for observing sagittal sections of the fetal cerebellar vermis, which has improved the diagnosis of posterior fossa malformation to an accuracy of 90% [9]. ...
... When fetal cardiac parameters measured at 7 a.m. and 7 p.m. were compared, there were no significant differences. Studies on MPI, previously used to assess fetal cardiac function, have been shown that Oral Glucose Tolerance testing does not affect MPI (34), but some conditions such as fetal growth restriction (35), oligohydramnios (36) and maternal diabetes (tip 1, tip 2 and unregulated GDM) (37) increase MPI. ...
... A 6 cm long linear array is lined on the side of the transducer, so the acoustic beam is perpendicular to pelvic organs, which could significantly improve the detection rate and resolution of imaging. This transducer had been proved to be useful in visualizing fine structures of anterior department when used in transvaginal way [7,8]. Until recently, it has not been used in transrectal way to evaluate POP, especially middle compartment prolapse. ...
... deletion syndrome. Deletions within 16p13.3-13.2 or RBFOX1 were reported in three boys with different presentations of syndromic UDT (Ramanathan et al., 2010;Milone et al., 2016;Pei et al., 2016), in one case associated with an anogenital anomaly, and in a case of Müllerian aplasia (Sandbacka et al., 2013). Similarly, RBFOX1 duplication was reported in a female with cloaca and associated renal anomalies (Harrison et al., 2014), supporting a functional role for this gene in urogenital development. ...
... Associated congenital anomalies can be present in 14-20% of cases, including anomalies of the corpus callosum in case of a pericallosal/midline lipoma and cleft lip and palate in case of teratoma [1]. Brain tumors can be part of a tumor predisposition syndrome or genetic disarrangement and genetic testing should be considered, even more in the presence of associated anomalies [4,5,13,[18][19][20]. Different tumor types can be found before birth and exhibit a different prognosis for the fetus itself and the mother to be. ...
... In this study, 20 cases were found to have abnormalities, including trisomy 21, trisomy 18, partial trisomy 22, Klinefelter syndrome, and CNVs in 2, 1, 1, 1, and 15 cases, respectively, and 2 CNVs were reportedly associated with intellectual disability or developmental delay. Compared with conventional karyotyping, chromosomal microarray analysis (CMA) improves the prenatal detection rates and can identify additional, clinically significant cytogenetic information in fetuses with CNS anomalies and a normal karyotype [29]. Therefore, it is recommended that CMA be used for prenatal diagnosis and karyotype analysis of mild VM fetuses. ...