Lesai Li's research while affiliated with Hunan Cancer Hospital and other places
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Publications (12)
The aim of this study was to elucidate the specific mechanism through which 7-difluoromethoxy-5,4’-dimethoxygenistein (DFMG) inhibits angiogenesis in atherosclerosis (AS) plaques, given its previously observed but poorly understood inhibitory effects. In vitro, a model using Human Umbilical Vein Endothelial (HUVEC-12) cells simulated the initial le...
Patients with recurrent or metastatic cervical cancer are in urgent need of novel prognosis assessment or treatment approaches. In this study, a novel prognostic gene signature was discovered by utilizing cuproptosis-related angiogenesis (CuRA) gene scores obtained through weighted gene co-expression network analysis (WGCNA) of The Cancer Genome At...
Background
Aberrant DNA damage repair (DDR) is one of the hallmarks of tumors, and therapeutic approaches targeting this feature are gaining increasing attention. This study aims to develop a signature of DDR-related genes to evaluate the prognosis of cervical cancer (CC).
Methods
Differentially expressed genes were identified between high and low...
Objectives:
Cervical squamous cell carcinoma is the most common cancer in female reproductive system. This study aims to explore the effect of microRNA-9-5p (miR-9-5p) on the migration, invasion, and epithelial-mesenchymal transition (EMT) process of cervical squamous cells.
Methods:
Bioinformatics were used to predict the miRNAs that could bind...
Cervical cancer ranks first in female reproductive tract tumors in terms of morbidity and mortality. Yet the curative effect of patients with persistent, recurrent or metastatic cervical cancer remains unsatisfactory. Although antitumor angiogenic drugs have been recommended as the first-line treatment options for cervical cancer, there are no comp...
Objectives: VEGF inhibitors, such as bevacizumab, inhibit angiogenesis and improve the prognosis of patients with recurrent or metastatic cervical cancer. Antiangiogenic drugs reduce the formation of immature and poorly functional blood vessels and induce the normalization of blood vessels. However, in many cases, features of the vascular normaliza...
Objectives: For locally advanced cervical cancer (LACC) patients without para-aortic lymph node metastasis, the standard treatment is pelvic radiotherapy plus concurrent chemotherapy. After standard treatment, 7-15% of patients had a recurrence in para-aortic lymph nodes. The present study aimed to evaluate the efficacy and side effects of modern r...
Angiogenesis plays an important role in the development and metastasis of tumors, and anti-angiogenesis agents are used to treat tumors. For example, the acute promyelocytic leukemia (APL) may be treated with arsenic trioxide. Angiogenesis in APL is a multi‑step dynamic equilibrium process coordinated by various angiogenic stimulators and inhibitor...
7-Difluoromethyl-5, 4’-dimethoxygenistein (DFMG), prepared by the difluoromethylation and alkylation of Genistein, is a new active chemical entity. In this study, we investigated the inhibitory effect of DFMG on Lysophosphatidyl choline (LPC)-induced apoptosis of human umbilical vein endothelial cells-12 (HUVEC-12) through mitochondrial apoptosis p...
7-Difluoromethyl-5, 4'-dimethoxygenistein (DFMG), prepared by the difluoromethylation and alkylation of Genistein, is an active new chemical entity. Its anti-atherosclerosis effect was found in a series of studies in vitro. In this article, we explored and evaluated the anti-atherosclerosis effect via its protection of endothelial function in ApoE(...
The timely onset of powerful uterine contractions during parturition occurs through thick and thin filament interactions, similar to other smooth muscle tissues. Calponin is one of the thin filament proteins. Phosphorylation of calponin induced by PKC-epsilon can promote the contraction of vascular smooth muscle. While the mechanism by which calpon...
Citations
... Thus, there is an urgent need to investigate novel biomarkers for prognosis and sensitivity of radiotherapy in these patients. However, the previous prediction models were focused on all CESC patients, neglecting the prognostic differences under different treatment modalities, leading to poor predictive accuracy (5)(6)(7). Consequently, a multivariate tool is necessary for predicting the prognosis and sensitivity of radiation to guide suitable treatment for CESC patients undergoing radical radiotherapy. ...
... After screening, samples without significant clinical data or with overall survival (OS) less than 90 days (13) were filtered out from further analysis. Moreover, AAGs were sourced from the MSigDB Team (http://www.broad.mit.edu/gsea/msigdb/) and pertinent literature (14)(15)(16), and are displayed in Table S1. Leveraging RNA-seq data from TCGA-colon adenocarcinoma (COAD) specimens accessed via UCSC Xena, all AAGs were discerned through the application of the limma package [P<0.05, ...
... For instance, targeting angiogenesis in gynecological cancer, such as with VEGF inhibitors like Bevacizumab, has become a fundamental clinical focus. These inhibitors block angiogenesis and have demonstrated improved prognosis for patients with recurrent or metastatic CC [67]. Histone Deacetylase inhibitors (HDACIs) function by increasing histone acetylation levels in various cell types by inhibiting their target enzymes, HDACs. ...
... However, anti-angiogenesis agents provide a great opportunity to develop anticancer agents. Recently, 7-difluoromethyl-5,4'-dimethoxygenistein, could provide its anti-proliferative action in acute promyelocytic leukemia HL-60 cells by initiating its anti-angiogenesis effect by the inhibition of TLR4/NF-κB cellular signaling [51]. Flk-1 (VEGFR2) expressions are found to be highly elevated in embryonic cells or developing new tumor cells. ...
... DFMG is involved in the regulation of different inflammatory cytokines, including E-selectin, intercellular adhesion molecule 1 (ICAM-1), IL-6 and TNF-α (33). In addition, DFMG interacts with the inhibition of different signaling pathway activations, including mitochondrial apoptosis and TLR4 signaling (33)(34)(35). ...
... Unfortunately, the discovery of new drugs that inhibit intraplaque angiogenesis has been slow. Therefore, further studies are needed to discover new antiangiogenic drugs that with acceptable side effects and to evaluate their potential efficacy in preventing plaque instability in AS. 7-difluoromethoxy-5,4-dimethoxygenistein (DFMG) is a new chemical entity synthesized with genistein as the leading compound by our team, and previously found it played a role in preventing the occurrence of AS [18,19]. Recently, we found that DFMG also had the effect of maintaining plaque stability in mice with AS, which may be related to DFMG reducing angiogenesis at the injury site. ...
... Tissues pre-incubated with 8-bromo-cAMP also demonstrated increased protein levels of calponin, as well as hinted towards reduced levels of both HSP20 Ser16-phosphorylation and total cofilin protein. Calponin has been shown to increase myometrial contractility in mice (Li et al. 2012), cofilin promotes actin depolymerisation when not phosphorylated at its Ser3 residue and HSP20 Ser16-phosphorylation promotes activation of cofilin (Karolczak-Bayatti et al. 2011;Hocking et al. 2013). Consequently, these protein-level changes observed after prolonged exposure to 8-bromo-cAMP may have contributed to the relatively greater spontaneous myometrial contractility we observed. ...
