Leonhard Starke's research while affiliated with Universität des Saarlandes and other places
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Publications (2)
Biological membranes have a stunning ability to adapt their composition in response to physiological stress and metabolic challenges. Little is known how such perturbations affect individual organelles in eukaryotic cells. Pioneering work has provided insights into the subcellular distribution of lipids in the yeast Saccharomyces cerevisiae , but t...
Biological membranes have a stunning ability to adapt their composition in response to physiological stress and metabolic challenges. Little is known how such perturbations affect individual organelles in eukaryotic cells. Pioneering work provided insights into the subcellular distribution of lipids, but the composition of the endoplasmic reticulum...
Citations
... Here, we used all-atom MD simulations to compute the free energy landscape of pore formation in complex models of eight different biological membranes including an asymmetric plasma membrane model, 35 models of several cellular organelles 36,37 and a model composed of E. coli lipid extract. 38 We computed potentials of mean force (PMFs) of pore nucleation and pore expansion to obtain two principal energetic parameters that quantify the membrane stability against defect formation: the pore nucleation free energy and the line tension along the pore rim. ...
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... In the trans-Golgi network (TGN) they provide a basis for protein and lipid sorting, while at the plasma membrane they provide an organizational principle that orchestrates cellular signaling (Simons and van Meer 1988;Simons and Ikonen 1997;Castello-Serrano et al. 2023). The endoplasmic reticulum (ER) membrane, on the other hand, is less rigid and more compressible due to its low sterol content and the high abundance of loosely packing lipids with monounsaturated fatty acyl chains ( Fig. 1; Antonny et al. 2015;Reinhard et al. 2022;Renne and Ernst 2023). Here, we discuss the role of the ER membrane in triggering and modulating ER stress. ...
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