Lei Zhang's research while affiliated with Shantou Central Hospital and other places
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Publications (8)
BACKGROUND
Postoperative pancreatic fistula (POPF) contributes significantly to morbidity and mortality after pancreaticoduodenectomy (PD). However, the underlying mechanisms remain unclear. This study explored this pathology in the pancreatic stumps and elucidated the mechanisms of POPF following PD.
CASE SUMMARY
Pathological analysis and 16S rRNA...
Background and Objectives:
Postoperative pancreatic fistula (POPF) contributes to significant morbidity and mortality after pancreaticoduodenectomy (PD). However, the underlying mechanisms of POPF remain unclear. This study is to explore the pathology in the pancreatic stump and elucidates the mechanisms of POPF following PD.
Methods:
Pathological...
Background and Objectives: Postoperative pancreatic fistula (POPF) contributes to significant morbidity and mortality after pancreaticoduodenectomy (PD). However, the underlying mechanisms of POPF remain unclear. This study is to explore the pathology in the pancreatic stump and elucidates the mechanisms of POPF following PD.
Methods: Pathological...
A comprehensive analysis of the prognostic, diagnostic, and biological significance of miR‐148a‐3p and cathepsin A (CTSA) in hepatocellular carcinoma (HCC) was performed using bioinformatics algorithms with The Cancer Genome Atlas (TCGA) data. miR‐148a‐3p and CTSA gene expression in HCC tissues and nontumor specimens was analyzed using TCGA databas...
Background
In the past century, postoperative pancreatic fistula (POPF) has been the major complication and cause of mortality after pancreaticoduodenectomy (PD). No one knows what exactly happens in the pancreatic stump after POPF. The hypothesis of this manuscript was to investigate changes that occur in the pancreatic stump.
Methods
Two patient...
Abstract The influences of 3-N-butyphthalide (NBP) on early brain injury (EBI) induced via mild subarachnoid hemorrhage (SAH) and its mechanism were explored. Establishment of SAH model was via autologous blood injection. The protection of NBP on EBI in SAH model mice was evaluated. Determination of neuronal apoptosis was conducted. Detection of bl...
Pancreatic cancer (PC), highly malignant, is one of the most lethal cancers. Interferon-induced transmembrane protein 1 (IFITM1) has recently been regarded as a new molecular marker in human cancers. However, the role of IFITM1 in PC remains unclear. In this study, a short hairpin RNA (shRNA) was constructed to assess the effect of IFITM1 on PANC-1...
Citations
... In addition, Cathepsin A (CTSA), a lysosome-encapsulated cellular proteases, its abnormal expression promotes tumor growth and metastasis 23,24. Zhao et al. 47 also reported that CTSA was overexpressed and associated with the carcinogenesis of liver cancer. BSG also known as Basigin or CD147, EMMPRIN, an immunoglobulin member, which can interact with extracellular, intracellular and membrane proteins and is the first reported protein to promote cancer development 48 . ...
... Some mesenchymal tissue-derived cancers such as glioma [28,29], osteosarcoma [30], and myeloid leukemia [31][32][33] also show IFITM1, IFITM2, or IFITM3 overexpressed in these cancers. However, the IFITMs expression in pancreatic cancer are rarely reported in the literature and just reported the IFITM1 was highly expressed in pancreatic cancer [34][35][36]. We analyzed IFITM1-3 mRNA expression difference in pancreatic cancer and adjacent tissues according to TCGA and GTEx database. ...
