Lei Liang's research while affiliated with Capital Medical University and other places
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Publications (17)
Objective
To evaluate left atrial volume and function in patients with paroxysmal atrial fibrillation (AF) combined with left atrial appendage thrombosis and patients with paroxysmal AF without left atrial appendage thrombosis by 3-dimensional speckle tracking imaging (3D-STI), and to explore the application value of this set of parameters in the e...
We aimed to construct and validate a multimodality MRI combined with ultrasound based on radiomics for the evaluation of benign and malignant breast diseases. The preoperative enhanced MRI and ultrasound images of 131 patients with breast diseases confirmed by pathology in Aerospace Center Hospital from January 2021 to August 2023 were retrospectiv...
Background. Peripheral blood mononuclear cells (PBMCs) serve as the immune system’s primary transportation hub outside of the affected ablated tissue. This study aims to explore the transcriptomic profiling of the immune response in PBMCs induced by microwave ablation (MWA) in low-risk thyroid cancer. Methods. For eight patients diagnosed with low-...
Objective
To evaluate potential improvements in the diagnosis of thyroid nodules when conventional ultrasound (US) is combined with contrast-enhanced US (CEUS).
Methods
We recruited 515 participants with 323 malignant and 192 benign nodules, who underwent both US and CEUS examinations at 8 different medical centers in China between October 2020 an...
To construct machine learning models based on radiomics features combing conventional transrectal ultrasound (B-mode) and contrast-enhanced ultrasound (CEUS) to improve prostate cancer (PCa) detection in peripheral zone (PZ).
A prospective study of 166 men (72 benign, 94 malignant lesions) with targeted biopsy-confirmed pathology who underwent B-mo...
Objective
The aim of this study is to investigate the value of ultrasound combined with computed tomography (CT) in identifying early low-grade appendiceal mucinous neoplasm and appendicitis.
Methods
Patients with early low-grade appendiceal mucinous neoplasm and appendicitis from September 2017 to September 2021, including 40 patients with low-gr...
Background Current guidelines recommend the use of conventional US for risk stratification and management of thyroid nodules. However, fine-needle aspiration (FNA) is often recommended in benign nodules. Purpose To compare the diagnostic performance of multimodality US (including conventional US, strain elastography, and contrast-enhanced US [CEUS]...
Objectives:
This study aimed to identify the diagnostic accuracy of combined ultrasonography (US) and computed tomography (CT) in evaluating the tumor burden of pseudomyxoma peritonei (PMP). Besides, we assessed the ability of this combination to predict the likelihood of complete resection.
Methods:
This retrospective study involved 504 patient...
Autophagy-related genes (ATGs) play critical roles in tumorigenesis and progression in gastric cancer (GC). The present study aimed to identify immune-based prognostic ATGs and verify their functions in tumor immune microenvironment (TIME) in GC. Macrophage infiltration was found to negatively correlate with prognosis in GC patients. After stratify...
The objective of this study was to predict the preoperative pathological grading and survival period of Pseudomyxoma peritonei (PMP) by establishing models, including a radiomics model with greater omental caking as the imaging observation index, a clinical model including clinical indexes, and a combined model of these two. A total of 88 PMP patie...
Purpose
To investigate the expression of carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), CA19-9, CA724, and CA242 in serum and ascites of pseudomyxoma peritonei (PMP) patients and evaluate the predictive value of these elevated biomarkers in pathological grade, completeness of cytoreduction (CC), and survival.
Methods
From May 2009 to...
Objectives
This study aimed to investigate the value of using ultrasound (US) preoperatively for predicting pathological classification, complete cytoreduction possibility, and survival rate of patients with pseudomyxoma peritonei (PMP).
Methods
We retrospectively studied PMP patients who were scheduled for cytoreductive surgery between May 2009 a...
Objectives
To evaluate the potential of a clinical-based model, a multiparametric ultrasound-based radiomics model, and a clinical-radiomics combined model for predicting prostate cancer (PCa).
Methods
A total of 112 patients with prostate lesions were included in this retrospective study. Among them, 58 patients had no prostate cancer detected by...
Purpose:
Gastric cancer (GC) is one of the most common and fatal malignancies globally. While microsatellite instability (MSI) index has earlier been correlated with survival outcome in gastric cancer patients, the present study aims to construct a risk-stratification model based on immune-related genes in GC patients with varying MSI status.
Res...
Purpose:
This study aimed to explore the value of preoperative ultrasonography (US) in evaluating the peritoneal cancer index (PCI) of pseudomyxoma peritonei (PMP).
Methods:
An ultrasound examination was performed on 59 patients with PMP before surgery, and the ultrasound PCI was evaluated. The accuracy of ultrasound PCI score was evaluated with...
Rationale
Pseudomyxoma peritonei is an unusual clinical condition, and the appendix and ovaries are reported as the primary sites.
Patient concerns
A 44-year-old man who was reported a 3-month history of lower abdominal pain and distention, along with increased abdominal girth, was admitted with a palpable tender mass in the central lower abdomen....
Citations
... Some recent literature on cancer detection has focused on machine learning methods [31,32]. From our perspective, we would like to assess how good these methods are vis-à-vis prostatectomy, if only we have data. ...
... [12,13] This complexity underscores the importance of a reliable diagnostic tool like Medicine FNA, which has evolved alongside advancements in ultrasound technology and molecular testing. [14,15] Bibliometrics employs both quantitative and qualitative analyses to elucidate various aspects of academic publications. [16] It not only identifies highly cited works and keywords but also reveals collaborations among countries, institutions, and authors. ...
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... PCI is a scoring system that helps predict long-term outcomes in PM and has been recognized as the most useful and reliable prognostic method to assess tumor plant burden in abdominal and pelvic examinations (Jacquet et al. 1993;Koh et al. 2009). PCI obtained from CT has been reported to have excellent performance in assessing tumor burden and predicting prognosis (Panagiotopoulou et al. 2021;Han et al. 2023). To the best of our knowledge, PCI change after therapy to assess treatment response and predict prognosis has not been undertaken by CT. ...
... Recently, a majority of studies have constructed massive prognostic models for STAD patients via analyzing the transcriptome datasets, of which most studies focused on annotating the transcriptomics data into known characteristics of gene sets, such as Autophagy-related genes (Tian et al., 2022), Cuproptosis-related lncRNA (Feng et al., 2022), Pyroptosis-related signatures (Guan et al., 2022) and so on. However, there were still some limitations to expand their application in clinical practice due to the instability and collinearity of gene expression. ...
... Few studies have focused on the management of patients with peritoneal carcinosis using radiomics-based clinical-practice-decision-support tools [156][157][158]. ...
... CA724, CEA, CA242, and CA19-9 are tumor markers commonly used for clinical diagnosis and are widely applied in gastric cancer screening. Studies have confirmed that the combined diagnosis of CA724, CEA, CA242, and CA19-9 can improve the accuracy into detect patients with peritoneal pseudomyxoma [9]. To observe the application value of combined testing of CA724, CEA, CA242, and CA19-9, 80 patients with suspected gastric cancer between January 2020 and January 2023 were selected for the study. ...
... Previous study [1] indicated that regions assigned a Gleason score of 7 exhibited statistically higher Young's modulus compared to regions with a Gleason score of 6. Building upon this finding, Wildeboer et al. [19] developed a random forest classifier analyzing B-mode, SWE and contrast-enhanced ultrasound, reached area under curves (AUC) of 0.75 for PCa. Liang et al. [10] utilized a radiomics model that incorporated B-mode and SWE to classify the PCa and achieved an AUC of 0.85. Notably, the above two methods required the biopsy pathology as reference to draw all region of interests (ROIs). ...
... In contrast, a study uncovered that NPR3 overexpression promoted the proliferation of colorectal cancer cells (43). Moreover, NPR3 was involved in constructing prognostic signatures to forecast the outcome of individuals with GC (60,94) and breast cancer (95)(96)(97). It was found that NPR3 actively stimulates the migration and proliferation of breast tumor cells (95). ...
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... 88,89 In such cases, US becomes an option, when performed by experienced operators, especially accurate for diaphragmatic, splenic, omental, and pelvic lesions. [90][91][92][93] If CT requires long waiting, an alternating schedule with US could be implemented. Intrathoracic recurrence is rarer than intraperitoneal yet still possible; therefore, chest imaging is required, and when CT is unavailable, chest X-ray could be considered. ...
... In contrast, high-grade lesions are generally related to the development of mucinous adenocarcinomas. In some cases these peritoneal mucinous tumors can also originate from other sites including the ovaries, mesenteric cysts, or colorectal tissue [3][4][5][6][7]. While PMP can develop across a wide age spectrum, it is most common in middle-aged or older individuals, and affects females more often than males [8]. ...
