Lars Christmansson's research while affiliated with Ludwig Institute for Cancer Research Sweden and other places
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Publications (2)
Studies have indicated that the 20-29 segment of islet amyloid polypeptide (IAPP) determines the fibril formation. Variations between species in this region explain why only some species develop islet amyloid. This assumption is strongly supported by our study where we have used synthetic peptides in an fibril formation test system. The sequence AI...
Amyloid deposits in the islets of Langerhans occur in association with type 2 diabetes mellitus (DM) in humans and cats and consist of a 37-amino-acid polypeptide known as islet amyloid polypeptide (IAPP). In order to find an explanation for the situation that islet amyloid (IA) does not develop in common rodent species, we have deduced the amino a...
Citations
... [56][57][58][59] Peptides S 20 NNFGAILSS 29 , F 23 GAIL 27, and N 21 NFGAIL 27 based on this sequence have been described to readily form amyloid fibrils. [60,61] The latter has been characterized by X-ray crystallography. [62] Furthermore, this sequence has been described as a promoter of hIAPP fibrils formation [63] or as an inhibitor when introduced in a macrocycle peptide derivative. ...
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