Konrad Brockmeier's research while affiliated with University of Cologne and other places
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Publications (230)
The benefits of maternal physical activity during pregnancy are well documented, but long-term effects on the child have been less studied. Therefore, we conducted a pilot follow-up study of a lifestyle intervention during pregnancy that aimed to investigate whether exercise (endurance and strength training) during pregnancy affects motor performan...
Lifestyle during pregnancy impacts the health of the mother and child. However, the extent to which physical activity affects maternal biomarkers and factors that might influence birth weight remains unclear. We analysed data from two lifestyle interventions in which the effects of an exercise programme (2x/week, 60–90 min) on the course of pregnan...
Microfluidics In article 2200246, Annette M. Schmidt's and her co‐workers' approach toward spherical, mm‐scaled PAAm hydrogel beads with adjustable, soft elastic properties as a matrix for scalable cell culture is described. The beads are produced by a continuous microfluidic approach, and after surface modification with biomarkers, their suitabili...
Many biological tissues resemble hydrogels and display Young's moduli below 50 kPa, corresponding to most cell types for the natural environmental conditions to grow. Contrastingly, conventional cell culture usually involves rigid substrates resulting in stiff priming effects, which are of increasing concern when it comes to scalable culturing of a...
Introduction
Endothelial cells (ECs) form the inner lining of all blood vessels of the body play important roles in vascular tone regulation, hormone secretion, anticoagulation, regulation of blood cell adhesion and immune cell extravasation. Limitless ECs sources are required to further in vitro investigations of ECs’ physiology and pathophysiolog...
Multicellular agglomerates in form of irregularly shaped or spherical clusters can recapitulate cell-cell interactions and are referred to as microtissues. Microtissues gain increasing attention in several fields including cardiovascular research. Cardiac microtissues are evolving as excellent model systems for drug testing in vitro (organ-on-a-chi...
Purpose
To assess the spectrum of associated anomalies, the intrauterine course, postnatal outcome and management of fetuses with truncus arteriosus communis (TAC)
Methods
All cases of TAC diagnosed prenatally over a period of 8 years were retrospectively collected in two tertiary referral centers. All additional prenatal findings were assessed an...
Purpose
To assess the spectrum of associated anomalies, the intrauterine course, postnatal outcome and management of fetuses with truncus arteriosus communis (TAC)
Methods
All cases of TAC diagnosed prenatally over a period of 8 years were retrospectively collected in two tertiary referral centers. All additional prenatal findings were assessed an...
Objectives:
To systematically review the prevalence of bacteraemia, triggered by dental intervention and home oral hygiene practices, in children. The network meta-analysis (NMA) quantitatively compared the risk of bacteraemia triggered by dental extractions and home and professional cleaning procedures.
Materials and methods:
Clinical trials wi...
Purpose: To assess the spectrum of associated anomalies, the intrauterine course, postnatal outcome and management of fetuses with truncus arteriosus communis (TAC)
Methods: All cases of TAC diagnosed prenatally over a period of 8 years were retrospectively collected in two tertiary referral centers. All additional prenatal findings were assessed a...
Background:
The prevalence of obesity in childhood is increasing worldwide and may be affected by genetic factors and the lifestyle (exercise, nutrition behavior) of expectant parents. Lifestyle factors affect adipokines, namely leptin, resistin, and adiponectin as well as cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL...
Murine embryonic stem cell derived cardiomyocytes (mESC-CMs) and murine induced pluripotent stem cell derived cardiomyocytes (miPS-CMs) were differentiated and co-cultured with irreversibly injured myocardial tissue slices. When beating clusters had integrated morphologically into the damaged tissue, isometric force measurements were performed. Eff...
Background Even after successful aortic coarctation (CoA) repair, hypertension causes premature morbidity and mortality. The mechanisms are not clear. The aim was to evaluate elastic wall properties and aortic morphology and to correlate these results with severity of restenosis, hypertension, aortic arch geometry, noninvasive pressure gradients, a...
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are promising candidates to treat myocardial infarction and other cardiac diseases. Such treatments require pure cardiomyocytes (CMs) in large quantities.
Methods: In the present study we describe an improved protocol for production of hiPSC-CMs in which hiPSCs are first convert...
Purpose:
To assess the intrauterine course, the outcome, and to establish a new prenatal echocardiographic scoring system to predict biventricular (BV) versus univentricular (UV) outcome of fetuses with severe pulmonary stenosis or atresia with intact ventricular septum (PSAIVS).
Methods:
All cases of PSAIVS diagnosed prenatally over a period of...
Abstract
Different approaches have been considered to improve heart reconstructive medicine and direct delivery of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) appears to be highly promising in this context. However, low cell persistence post-transplantation remains a bottleneck hindering the approach. Here, we present a novel strategy to...
Aims:
Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) have become a promising tool in cardiovascular safety pharmacology. Immaturity of iPS-CMs remains an ongoing concern. We compared electrophysiological and contractile features of cardiac bodies (hiPS-CBs) derived from human-induced pluripotent stem cells and human neonatal and in...
Pathophysiological conditions, such as myocardial infarction and mechanical overload affect the mammalian heart integrity, leading to a stiffened fibrotic tissue. With respect to the pathophysiology of cardiac fibrosis but also in the limelight of upcoming approaches of cardiac cell therapy it is of interest to decipher the interaction of cardiomyo...
Purpose To assess the intrauterine course, associated conditions and postnatal outcome of fetuses with pulmonary atresia with ventricular septal defect (PAVSD).
Methods All cases of PAVSD diagnosed prenatally over a period of 10 years with a minimum follow-up of 6.5 years were retrospectively collected in 3 tertiary referral centers.
Results 50 cas...
Objective
To assess the spectrum of associated anomalies, the intrauterine course, postnatal outcome and management of fetuses with double outlet right ventricle (DORV).
Methods
All cases of DORV diagnosed prenatally over a period of 8 years were retrospectively collected in a single tertiary referral center. All additional prenatal findings were...
Circulating venous bubbles after dives are associated with symptoms of decompression sickness in adults. Up to now it is not known to what extent children and adolescents are subjected to a bubble formation during their shallow dives and if there are possible indications for that. The aim of this pilot study is to investigate whether bubbles and/or...
Background
Implantable cardioverter defibrillator (ICD) therapy is indicated in patients with structural heart disease who have had an aborted cardiac arrest (ACA). After atrial repair of d-transposition of the great arteries (d-TGA, Mustard repair) patients seem to be at a higher risk of failing intraoperative subcutaneous ICD (S-ICD) shock testin...
In the summer of 2016, delegates from the German Respiratory Society (DGP), the German Society of Cardiology (DGK) and the German Society of Pediatric Cardiology (DGPK) met in Cologne, Germany, to define consensus-based practice recommendations for the management of patients with pulmonary hypertension (PH). These recommendations were built on the...
Exercise during pregnancy has beneficial effects on maternal and offspring’s health in humans and mice. The underlying mechanisms remain unclear. This comparative study aimed to determine the long-term effects of an exercise program on metabolism, weight gain, body composition and changes in hormones [insulin, leptin, brain-derived neurotrophic fac...
Background:
Juvenile overweight is increasing, and effective preventive measures are needed. After years of arbitrarily assigning these measures disregarding socioeconomic and/or cultural differences, it has become necessary to tailor interventions more specific to these target groups. Providing data for such an intervention is the objective of th...
Congenital malformations of the heart and vessels occur in 5-9 per 1.000 live births. Approximately 85% of the patients born with congenital malformations of the heart and vessels survive into adult life. With improved life expectancy, growing attention is given to the question of whether and to what extent physical activity should be recommended i...
The 2015 European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension are also valid for Germany. The guidelines contain detailed recommendations for different forms of PH, and specifically address PH associated with congenital heart disease (CHD). However, the practical implementation of the European Guidelines in Germany requires the...
The ECG in children has a number of characteristic differences compared to the ECG of the adult. The transition of the ECG in neonates after birth represents dynamic changes of the circulatory system due to the postnatal adaptation, different physiologic properties of the fetal and neonatal myocardium, the location and orientation of the heart in t...
Figure S1. Relation between the age of the patients at the surgery and their clinical diagnosis. Patients with HLHS and TGA were operated at a significantly lower age whereas in the other patients the time of surgery did not depend on the diagnosis. Lines represent means. DORV indicates double‐outlet right ventricle; HLHS, hypoplastic left heart sy...
Background
The postnatal development of myofibrillar mechanics, a major determinant of heart function, is unknown in pediatric patients with tetralogy of Fallot and related structural heart defects. We therefore determined the mechanical properties of myofibrils isolated from right ventricular tissue samples from such patients in relation to the de...
Objective:
To assess the spectrum of associated anomalies, intrauterine course and outcome in fetuses with absent pulmonary valve syndrome (APVS).
Methods:
All cases with a prenatal diagnosis of APVS at two centers over a period of 13 years were analyzed retrospectively. APVS was diagnosed in the presence of rudimentary or dysplastic pulmonary v...
Objective:
A standardised diagnostic definition of protein-losing enteropathy (PLE) in Fontan patients serves both patient care and research. The present study determined whether a diagnostic definition of PLE was routinely used in published clinical Fontan studies, and to identify potentially relevant diagnostic criteria for composing a uniform P...
Transplantation of stem cell-derived cardiomyocytes is one of the most promising therapeutic approaches after myocardial infarction, as loss of cardiomyocytes is virtually irreversible by endogenous repair mechanisms. In myocardial scars, transplanted cardiomyocytes will be in immediate contact with cardiac fibroblasts. While it is well documented...
Objective: The definition of protein-losing enteropathy (PLE) in Fontan patients is variable and lacks standardization. We sought to 1) determine whether a PLE definition in Fontan is routinely used, and (2) identify useful diagnostic building blocks for composing a uniform PLE definition. Methods: A systematic search of Medline (PubMed) was perfor...
Zebrafish ( Danio rerio ) have become a popular model in cardiovascular research mainly due to identification of a large number of mutants with structural defects. In recent years, cardiomyopathies and other diseases influencing contractility of the heart have been studied in zebrafish mutants. However, little is known about the regulation of contr...
This article provides expert opinion on the use of cardiovascular magnetic resonance (CMR) in young patients with congenital heart disease (CHD) and in specific clinical situations. As peculiar challenges apply to imaging children, paediatric aspects are repeatedly discussed. The first section of the paper addresses settings and techniques, includi...
Objectives: Isolation and comparison of cellular and molecular characteristics of MSCs derived from full term amniotic membrane (AM), endometrium and ovarian tissues.
Investigation of a possible therapeutic potential for AM MSCs in the female reproductive tract.
Study design & methods: Human amniotic membranes (AMs) from term placentas (N = 8), end...
Cardiomyocytes (CMs) from induced pluripotent stem (iPS) cells mark an important achievement in the development of in vitro pharmacological, toxicological and developmental assays and in the establishment of protocols for cardiac cell replacement therapy. Using CMs generated from murine embryonic stem cells and iPS cells we found increased cell–mat...
![Figure 1: Weight gain according to IOM guidelines [12] depending on...](profile/Christine-Joisten-Formerly-Graf-2/publication/263972177/figure/fig3/AS:267666854248506@1440828159487/Weight-gain-according-to-IOM-guidelines-12-depending-on-weight-classification_Q320.jpg)
Increasing rates of overweight have been reported. In Germany, women of childbearing age are especially affected. Those women are at increased risks of several peri- and postnatal complications. The purpose of this study was to carry out Germany’s first study in terms of secular trends of overweight and weight gain during pregnancy related to foeta...
Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) might become therapeutically relevant to regenerate myocardial damage. Purified iPS-CMs exhibit poor functional integration into myocardial tissue. The aim of this study was to investigate whether murine mesenchymal stem cells (MSCs) or their conditioned medium (MScond) improve the inte...
Objectives
Cell transplantation is a promising strategy for therapeutic treatment of ischemic heart disease. Systemically delivered
mesenchymal stem cells (MSCs) can home to sites of ischemia and tissue injury, including the ischemic heart, allowing
the noninvasive administration of MSCs intravenously.
Materials & methods
In this study, Wharton jel...
Pluripotent stem cells have great potential for regenerative medicine; however, their clinical use is associated with a risk of tumor formation. We utilized pluripotent cells expressing green fluorescent protein and puromycin resistance under control of the Oct4 promoter to study the persistence of potential pluripotent cells under embryoid body (E...
Sudden cardiac death
Identifying young patients at risk of malignant arrhythmia and sudden cardiac death remains a challenge. It is increasingly being recognized that sudden death, syncope and aborted cardiac arrest at a young age in patients with a structurally normal heart may be the result of ion channel disorders, the so-called channelopathies....
Background: The first electrocardiograms (ECGs) have been recorded with a capillary electrometer in the late 19(th) century by John Burdon Sanderson and Augustus Waller. In 1903 Willem Einthoven used the much more sensitive string galvanometer and was awarded Nobel Price in Medicine for this discovery. Though the physical principles of that era are...
Adult peripheral blood contains a limited number of endothelial progenitor cells that can be isolated for treatment of ischemic diseases. The adipose tissue became an interesting source of stem cells for regenerative medicine. This study aimed to investigate the phenotype of cells obtained by culturing adipose-derived mesenchymal stem cells (ad-MSC...
During the last years because of the progress in magnetic resonance imaging (MRI) magnetic resonance angiography (MRA) has become a serious alternative to conventional X-ray angiography. The potential of MRA in combination with methods for three-dimensional reconstruction will be presented and different methods for image post-processing are discuss...
Objectives: There seems to be a difference in the re-coarctation incidence after neonatal aortic arch enlargements depending on the material applied. Three different materials were used, equine and bovine pericardium and pulmonary homograft patches, and their re-intervention incidence rates were compared. All patients were operated using the same t...
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) provide the unique opportunity to study the very early development of the human heart. The aim of this study was to investigate the effect of calcium and beta-adrenergic stimulation on the contractile properties of early hESC-CMs. Beating clusters containing hESC-CMs were co-cultured in vi...
Cryoablation is safe for the ablation of substrates in proximity to the AV node, because the initial lesion is reversible. We report our results of cryoablation in a transregional center for ablation in children and adolescents.
Data on 39 children and adolescents (4 - 18 years of age) who had been treated with cryo energy were analyzed retrospecti...
Combination of ruptured sinus of Valsalva aneurysm (SVA), and a coexisting asymptomatic adult aortic isthmic coarctation is extremely rare. The timing and sequence of surgical and/or interventional repair of these two pathologies are controversial. We present a case of a 37-year-old male who was admitted to our department because of severe acute co...
Wharton's jelly (WJ) is a rich source of multiple-lineage differentiating cells, recently proposed for cell replacement therapy. However, their ability to integrate into the cardiac tissue has not been elucidated, yet. We employed in vitro cardiac transplantation models to investigate the capacity of a novel population of human WJ-derived mesenchym...
Transplantation of purified pluripotent stem cell-derived cardiomyocytes into damaged myocardium might become a therapy to improve contractile function after myocardial infarction. However, engraftment remains problematic. Aim of this study was to investigate whether murine embryonic fibroblasts (MEFs) support the functional integration of purified...
Unlabelled:
The verapamil-sensitive Belhassen tachycardia is a ventricular reentrant tachycardia, involving left-sided Purkinje fibers and abnormal Purkinje or myocardial tissue. Ablation is feasible, targeting a diastolic fascicular potential in the apical left ventricle.
Case report:
We report on a 13-year-old girl with left posterior fascicul...
Bei einem 5-jährigen, bislang herzgesunden Mädchen trat nach 14-tägiger antibiogrammgerechter Therapie (Ceftriaxon) einer Pneumokokkensepsis/-meningitis eine vorher nicht nachgewiesene endokarditische Vegetation an der Trikuspidalklappe mit embolischer Pneumonie auf. Eine durch Pneumokokken hervorgerufene, selten Kombination einer manifestierenden...
Congenital malformations of the heart and vessels occur in 5–9 per 1,000 live births.1,2 The spectrum of congenital malformations of the heart and vessels is diverse. Defects can roughly be categorized into left
to right shunt lesions, cyanotic lesions, obstructive lesions, and complex lesions associated with common mixing and single
ventricle phys...
The umbilical cord blood derived endothelial progenitor cells (EPCs) contribute to vascular regeneration in experimental models of ischaemia. However, their ability to participate in cardiovascular tissue restoration has not been elucidated yet. We employed a novel coculture system to investigate whether human EPCs have the capacity to integrate in...
Cardiomyocytes generated from embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells are suggested for repopulation of destroyed myocardium. Because contractile properties are crucial for functional regeneration, we compared cardiomyocytes differentiated from ES cells (ESC-CMs) and iPS cells (iPS-CMs). Native myocardium served as cont...
Little is known about the outcome of acute thrombotic occlusion of segments of the cavopulmonary connections (CPC) in infants and children with univentricular hearts. Early recognition and aggressive therapy may result in successful salvage of some of these patients. Five consecutive patients (age range 4-8 months) presenting with acute occlusion o...
Parents of children with congenital cardiac disease suffer from psychological stress and financial burdens. These costs have not yet been quantified.
In cooperation with paediatricians, social workers, and parents, a questionnaire was devised to calculate direct non-medical and indirect costs. Direct non-medical costs include all costs not directly...
In this study we investigated the postnatal developmental changes in sarcomeric protein expression in parallel with contractile parameters in myofibrils isolated from small resections from the right ventricular (RV) outflow tract in 25 patients with Tetralogy of Fallot and related congenital heart diseases (CHD). These CHDs are associated with RV h...
Ventricular preexcitation may be associated with dilated cardiomyopathy, even in the absence of recurrent and incessant tachycardia.
This report describes the clinical and electrophysiologic characteristics of 10 consecutive children (6 males), with median age of 8 years (range, 1-17 years), who presented with dilated cardiomyopathy and overt ventr...
Congenital Long-QT-syndromes comprise a group of diseases characterised by specific genetic defects of variable genotype and phenotype. The cut-off value of 0.44 has led to a substantial amount of falsely positive results. The American recommendations for determining eligibility for competition in athletes allow for higher cut-off-values taking int...
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) might provide cells to repopulate injured myocardium. Electrical coupling of these cells to the host myocardium is a prerequisite for improved functionality. The aim of this study was to investigate electrical interaction of hESC-CMs with myocardial tissue and to identify factors challengi...
Objectives: Early (within 30 days) and late arrhythmias (after 6 months) are relatively common following completion of the Fontan operation in its original form, which contributes significantly to late morbidity and mortality. Aim of the study was to compare a consecutive series of Fontan patients who had undergone Fontan completion either using an...
Citations
... Notably, even autologous hiPSCs exhibit a low immunogenicity profile [53]. Nevertheless, this concern can be addressed using human-derived components [54] or serum-free cultivation strategies [55] to avoid the use of xenogeneic materials in generating xeno-free (XF)-hiPSC-ECs. ...
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... Microfluidics can be used to create visible channels with a simulated vascular network structure, as well as to precisely control the flow conditions of trace fluids in microchannels to simulate cardiovascular blood flow [169][170][171]. Therefore, microfluidic devices related to CVDs can be customized for specific applications such as VOC for pathogenesis studied, HOC for drug screening, and microfluidic scaffolds for implantation. ...
... Oral microbiota, including bacteria, viruses, archaea, and fungi, are known to cause caries and periodontitis, which are the two most common oral diseases. In addition, oral microbiota is considered a significant risk factor for systemic health conditions in humans, such as diabetes mellitus, cardiovascular disease, and bacteremia, and premature and low birth weight infants [8,9]. For a better understanding of colonization of bacterial species and development of mature microbiota in the oral cavity, it is important to consider oral microbiota development during infancy [10]. ...
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... 4,5 Prenatal echocardiographic diagnosis of CHD has improved significantly over the last decade and the current prenatal echocardiographic truncus arteriosus diagnostic accuracy is reported as high as 87%. [6][7][8][9] Nevertheless, diagnosing truncus arteriosus on prenatal echocardiography can be challenging as it shows similarities with conditions like severe tetralogy of Fallot and pulmonary atresia with ventricular septal defect. Additional factors like fetal movement, fetal positioning, and maternal habitus also play an important role. ...
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... The basis of the counseling was previously completed dietary recalls. Background information about the intervention design has been published elsewhere [18,24]. ...
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... Aortic coarctation is a frequent kind of congenital cardiovascular disorder that affects 1 in every 3000 live births and is diagnosed in 5-8% individuals with congenital cardiovascular disorders. It may manifest alone or in conjunction with a number of other heart and vascular defects, including ventricular septal defect, bicuspid aortic valve, patent ductus arteriosus, and aortic arch hypoplasia [1,3] . A discrete or extended stenosis in the aorta, often near the isthmus, with numerous levels of severity is what is known as coarctation of the aorta. ...
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... were used: UKKi032-C (NP0141-31B) (female) (Fig. S1 †), UKKi037-C (NP0144-41) (female), and NP0143-18 UKKi036-C (male). 36 hiPSCs were differentiated into hiPSC-CMs using a GiWi differentiation protocol. 37 In short, at day 0, with hiPSCs at 90% confluency, medium was changed to heparin medium (see Table S1 † for media compositions) with 4 μM CHIR99021 (Selleck Chemicals). ...
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... [13,14] Previous studies have described the fetal echocardiographic features of critical CHDs with DDPC in relation to anatomic diagnosis, presence of branch pulmonary artery (PA) stenosis, and prediction of neonatal outcomes. [15][16][17] However, there are no studies evaluating prenatal morphology of the ductus arteriosus with respect to its origin, course, and tortuosity in CHD with DDPC and its impact on postnatal management. Newer technology like three-dimensional/four-dimensional (3D/4D) spatiotemporal image correlation (STIC) fetal echocardiography has the potential to provide additional anatomic insights over conventional cross-sectional echocardiography that may enable improved postnatal management of complex forms of CHD. ...
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... In contrast to our result, Batte et al. illustrated preoperative factors such as the history of pneumonia was not statistically related to undernutrition among children post-operation (14). One likely explanation is the corrective surgery triggered catch-up growth in patients (43). Poor feeding elevates the risk of infections, such as pneumonia, which conversely worsens children's nutritional condition, forming a vicious cycle. ...
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... liver (modulus < 10 kPa 3,4 ) possesses functional hepatic lobules arranged in a radial distribution, cardiac tissue (modulus ~ 10 kPa 5-10 ) exhibits an organized orientation, blood vessels (modulus ~ 10 3 kPa 11 ) feature network-like structures. Moreover, the modulus of cardiac tissue increases with development, starting at approximately 12 kPa in the embryonic stage and reaching around 30 kPa in adulthood 12 . This makes the manufacturing of diverse tissue scaffolds challenging while aiming to match the complexed structural and mechanical properties. ...
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