Kimaya M. Bakhle's research while affiliated with Cornell University and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (10)
Immune checkpoint blockade (ICB) therapy has emerged as a promising approach for treating breast cancer, however, only a fraction of patients derives clinical benefit and the underlying reasons for heterogeneous responses remain elusive. The epithelial-to-mesenchymal transition (EMT) enables these carcinomas to metastasize and acquire resistance to...
Introduction
Understanding a tumor’s immune context is paramount in the fight against cancer. Oral melanoma in dogs serves as an excellent translational model for human immunotherapy. However, additional study is necessary to comprehend the immune landscape of dog oral melanomas, including their similarity to human melanomas in this context.
Metho...
Studies in multiple organisms have shown that aging is accompanied by several molecular phenotypes that include dysregulation of chromatin. Since chromatin regulates DNA-based processes such as transcription, alterations in chromatin modifications could impact the transcriptome and function of aging cells. In flies, as in mammals, the aging eye und...
Mammary stem/progenitor cells are fundamental for mammary gland development and function. However, much remains to be elucidated regarding their function in mammals beyond the traditionally studied rodents, human, and to a lesser extent, ruminants. Due to the growing appreciation for microRNAs (miRNAs) as regulators of stem cells and their progenit...
Studies in multiple organisms have shown that aging is accompanied by several molecular phenotypes, that include dysregulation of chromatin. Since chromatin regulates DNA-based processes such as transcription, alterations in chromatin modifications could impact the transcriptome and function of aging cells. In flies, as in mammals, the aging eye un...
Two out of five patients with non-small cell lung cancer (NSCLC) develop brain metastases with 3-8 month overall survival time. One of the greatest challenges for developing chemotherapeutics for brain metastases of NSCLC is the blood-brain barrier (BBB). The BBB is composed of endothelial cells with distinct tight junctions, pericytes, a unique ba...
Age-related eye disease is a prevalent problem that is exacerbated by the rising, aging population. Drosophila melanogaster serves as a powerful model organism for studying age-related eye disease, as they share 60% of their genetic material with humans. Here, we seek to understand how changes in gene expression regulate photoreceptor neuron surviv...
The aging eye experiences physiological changes that include decreased visual function and increased risk of retinal degeneration. Although there are transcriptomic signatures in the aging retina that correlate with these physiological changes, the gene regulatory mechanisms that contribute to cellular homeostasis during aging remain to be determin...
The chromatin landscape defines cellular identity in multicellular organisms with unique patterns of DNA accessibility and histone marks decorating the genome of each cell type. Thus, profiling the chromatin state of different cell types in an intact organism under disease or physiological conditions can provide insight into how chromatin regulates...
The chromatin landscape defines cellular identity in multicellular organisms with unique patterns of DNA accessibility and histone marks decorating the genome of each cell type. Thus, profiling the chromatin state of different cell types in an intact organism under disease or physiological conditions can provide insight into how chromatin regulates...
Citations
... In addition to changes in gene expression, there are agedependent alterations to chromatin accessibility, histone marks, and DNA methylation in the eye. For example, changes in chromatin accessibility have been detected at the onset of the disease state for AMD (Wang et al., 2018) and in aging Drosophila photoreceptors (Jauregui-Lozano et al., 2023). Further, changes in DNA methylation are observed in aging mouse rods, particularly near genes involved in energy metabolism (Corso-Díaz et al., 2020). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/1074498556162048-1633191827511_Q64/Juan_Jauregui3.jpg)
... Mammosphere-derived epithelial cells (MDEC) populations were generated as previously described [4,37,43] from mammary tissue fragments used in this study. Briefly, mammary tissues and single cell suspensions were isolated as described above and 3 x 10 6 cells were plated in adherent 6-well culture plates (Corning Inc.). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/467134456307714-1488384941993_Q64/Gat-Rauner-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/314170594004993-1451915514634_Q64/Gerlinde-Van-De-Walle.jpg)
... Serotonergic signaling may only cause weak or microdomain-restricted changes in some pathways, and it is possible that the primary adaptive response to an increase in extracellular serotonin is posttranscriptional. Additional -omic strategies, notably ChIP-seq and ATAC-seq [101,102], have been used with great success from similar starting samples, and provide a complementary approach to RNA-seq in future studies. ...
