Keyur M. Shah's research while affiliated with Virginia Commonwealth University and other places
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Publication (1)
Ivabradine is a pharmacologic agent that inhibits the funny current responsible for determining heart rate in the sinoatrial node. Ivabradine’s clinical potential has been investigated in the context of heart failure since it is associated with reduced myocardial oxygen demand, enhanced diastolic filling, stroke volume, and coronary perfusion time;...
Citations
... However, the expressions of these genes increases as a result of HF (122). In support of this study, clinical trials have demonstrated the beneficial effects of ivabradine, an I f inhibitor, in HF (123)(124)(125). Additional studies are warranted to establish the exact role of I f and its genes HCN2/HCN4 in HF. ...
