Kevin B Hu's research while affiliated with Cornell University and other places
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Publications (2)
The karyotype, or number and arrangement of chromosomes, has varying levels of stability across both evolution and disease. Karyotype changes often originate from DNA breaks near the centromeres of chromosomes, which generally contain long arrays of tandem repeats or satellite DNA. Drosophila virilis possesses among the highest relative satellite a...
Repetitive satellite DNA is highly variable both within and between species, and is often located near centromeres. However, the abundance or array length of satellite DNA may be constrained or have maximum limits. Drosophila virilis contains among the highest relative satellite abundances, with almost half its genome composed of three related 7 bp...
Citations
... This comprehensive compilation, often referred to as the "satellitome", has yielded invaluable insights into various evolutionary aspects. These insights encompass karyotype evolution, genome diversity, phylogenetic relationships, as well as the evolution and structure of sex chromosomes, and their contributions to speciation processes [14][15][16][17]. However, the arrangement of satDNA sequences on chromosomes in birds is yet mainly unknown since most studies on the subject concentrated on specific species or satDNA families [18][19][20][21][22][23][24]. ...
... Here, we described that SatDNA content is highly variable in Drosophila genomes, and this variation roughly follows phylogenetic relationships in which closely related species tend to show a similar SatDNA content. We observed that genome size variation in the Drosophila subgenus shows a strong correlation with the expansion/shrinkage of SatDNA sequences, supporting the hypothesis that SatDNA dynamic changes play a role in genome size evolution (Flynn et al. 2021;Majid and Yuan 2021). Conversely, we described that genome size variation in Sophophora correlates with TE content ( fig. ...
