Kethylen Barbara Barbosa Cardoso's research while affiliated with Federal University of Pernambuco and other places

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Publications (13)

Figure 4. FTIR Spectra (before and after UV exposure) of the polysaccharide films (a) polysaccharide film with commercial collagenase enzyme (b) and polysaccharide film with collagenase produced using Streptomyces parvulus (c).
Thickness and moisture content for the polysaccharide films before and after immobiliza- tion (values expressed as average ± standard deviation).
Color parameters L* (luminosity), a* (−a* = greenness and +a* = redness), b* (−b* = blueness and +b* = yellowness) and Y (opacity) for the polysaccharide films before and after immobilization (values expressed as average ± standard deviation).
Effect of concentration on Young's modulus (YM), tensile strength (TS) and elongation at break (EB) of the films (w/v) films before and after immobilization of collagenases in the film- forming mixture.
Physicochemical Properties of a Bioactive Polysaccharide Film from Cassia grandis with Immobilized Collagenase from Streptomyces parvulus (DPUA/1573)
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May 2024

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25 Reads

Cosmetics

Kétura Ferreira

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Kethylen Cardoso

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Romero Brandão-Costa

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[...]

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José Teixeira

(1) Background: Polysaccharide films are promising vehicles for the delivery of bioactive agents such as collagenases, as they provide controlled release at the wound site, facilitating tissue regeneration. This study aimed to investigate the physicochemical properties of Cassia grandis polysaccharide films with immobilized collagenase from Streptomyces parvulus (DPUA/1573). (2) Methods: Galactomannan was extracted from Cassia grandis seeds for film production with 0.8% (w/v) galactomannan and 0.2% (v/v) glycerol with or without collagenases. The films underwent physical-chemical analyses: Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), color and opacity (luminosity-L*, green to red-a*, yellow to blue-b*, opacity-Y%), moisture content, water vapor permeability (WVP), thickness, contact angle, and mechanical properties. (3) Results: The results showed similar FTIR spectra to the literature, indicating carbonyl functional groups. Immobilizing bioactive compounds increased surface roughness observed in SEM. TGA indicated a better viability for films with immobilized S. parvulus enzymes. Both collagenase-containing and control films exhibited a bright-yellowish color with slight opacity (Y%). Mechanical tests revealed decreased rigidity in PCF (−25%) and SCF (−41%) and increased deformability in films with the immobilized bioactive compounds, PCF (234%) and SCF (295%). (4) Conclusions: Polysaccharide-based films are promising biomaterials for controlled composition, biocompatibility, biodegradability, and wound healing, with a potential in pharmacological applications.

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