Keda Lu's research while affiliated with Zhejiang Chinese Medical University and other places
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Publications (6)
Background
The coronavirus disease 2019(COVID-19) pandemic has caused over 656 million confirmed cases and over 6.6 million deaths worldwide. Chronic kidney disease (CKD) is considered a high-risk factor for COVID-19; therefore, considerable research has been conducted in this field. Therefore, this study aims to conduct a bibliometric analysis of...
Objectives
Diabetic nephropathy (DN) is the most common microvascular complication of diabetes mellitus. This study investigated the mechanism of triptolide (TP) in podocyte injury in DN.
Methods
DN mouse models were established by feeding with a high-fat diet and injecting with streptozocin and MPC5 podocyte injury models were induced by high-glu...
Objectives
Platelet clumps present in anticoagulant specimens may generate a falsely decreased platelet count and lead to an incorrect diagnosis. A clear understanding of the ability of a haematology analyser (HA) to detect platelet clumps is important for routine work in the clinical laboratory.
Methods
Citrate-anticoagulated whole-blood samples...
The Yi–Qi–Jian–Pi–Xiao–Yu–Xie–Zhuo (YQJPXYXZ) formula has been used for treating chronic kidney disease (CKD) for many years with good efficiency based on the cumulative empirical experience of previous practitioners. Impairment of the IGF-1/PI3K/Akt signaling pathway plays an important role in mediating muscle wasting. This study aimed to observe...
Activation of the renin angiotensin system and renal oxidative stress (OS) are critical contributors in the progression of chronic kidney disease(CKD). Recent studies have confirmed that the angiotensin-converting enzyme 2-angiotensin (1-7)-Mas(ACE2/Ang(1-7)/Mas) axis, the important components of renin angiotensin system, protected kidneys against...
Purpose
This study investigates some clinical characteristics of maintenance hemodialysis patients with new‐onset epilepsy.
Methods
Thirty‐five patients with new‐onset epilepsy who underwent maintenance hemodialysis were selected for study. Sixty patients undergoing routine hemodialysis were selected as the control group. We evaluated and compared...
Citations
... The CARD domain of ASC can bind to the CARD domain of effector protein to form CARD, which interact mutually [20]. The N-terminal PYD domain binds to and interacts with the PYD domain of NLRP3, while the C-terminal CARD domain connects with the CARD domain of pro-casepase-1, mediating the formation of NLRP3 inflammasome complex through recruitment of pro-caspase-1 [21,22]. The Caspase-1 activation prompts the cleavage, maturation, and discharge of cytokine precursors like IL-1β and IL-18, ultimately resulting in the inflammatory necrosis of cells (e.g., glial and neuronal) [23]. ...
... In a study by Xu et al., 12 on the samples with low platelet counts showed that the total sensitivities of the platelet, CLP -The corresponding peripheral smear shows large CLP of platelets. Platelet count of this case on peripheral smear is found to be 180000 per cubic mm. ...
... Previous studies have proven that the disruption of the IGF/AKT signaling pathway was responsible for protein synthesis downregulation in the diaphragm [17]. Moreover, IGF-1 could also modulate protein degradation through the ubiquitin-proteasome system (UPS) [18,19] and autophagy [20]. Another key regulator of skeletal muscle atrophy is the forkhead box protein O1 (FOXO1) which regulates the expressions of genes associated with muscle atrophy [21]. ...
... In addition, plasma ACE also significantly correlates to IL-6 levels, yet the correlation also seems weak. ACE, a key enzyme of the classical axis within the RAAS, converts Ang I to Ang II, which promotes water-sodium retention, vasoconstriction, induction of reactive oxygen species (ROS), apoptosis, and stimulation of extracellular matrix synthesis (Shi et al., 2020). Several previous investigations have revealed an increase in plasma ACE levels in CKD patients (Anguiano et al., 2015;Yang et al., 2017). ...
... A large epidemiological study of the Danish registry reported that increased numbers of antibiotic prescriptions for a single patient correlate with increased risk for epilepsy (Norgaard et al., 2012). Another study reported increased seizure risk in hemodialysis patients that were administered cephalosporin antibiotics (Zhang et al., 2019). A meta-analysis of all randomized controlled human trials of carbapenem antibiotics reported a significant increase in seizure risk associated with carbapenem usage (Cannon et al., 2014). ...
