Kazuyuki Sugahara's research while affiliated with Kobe Pharmaceutical University and other places
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Publications (4)
Oversulfated chondroitin sulfate (CS) variant chains, CS-D, CS-E, CS-H and CS-K, all of which are characterized by di-or trisulfated disaccharide units, were originally discovered in tissues of lower marine organisms: shark cartilage, squid cartilage, hagfish notochord and king crab cartilage, respectively. Our studies and others have demonstrated...
Angiomodulin (AGM/TAF/mac25) is a 30-kDa glycoprotein that was identified as an integrin-independent cell adhesion protein secreted by human bladder carcinoma cells. AGM is highly accumulated in small blood vessels of tumor tissues. In the present study, we attempted to identify the cell surface receptor and the cell-binding site of AGM using ECV-3...
Angiomodulin (AGM/TAF/mac25) is a 30-kDa glycoprotein that was identified as an integrin-independent cell adhesion protein secreted by human bladder carcinoma cells. AGM is highly accumulated in small blood vessels of tumor tissues. In the present study, we attempted to identify the cell surface receptor and the cell-binding site of AGM using ECV-3...
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Tumor-derived adhesion factor (TAF) was previously identified as a cell adhesion molecule secreted by human bladder carcinoma cell line EJ-1. To elucidate the physiological function of TAF, we examined its distribution in human normal and tumor tissues. Immunochemical staining with an anti-TAF monoclonal antibody showed that TAF was specifically ac...
Citations
... On the other hand, IGFBP7 was shown to be up-regulated in tumor blood vessels and was capable of promoting vascular angiogenesis (50,65). In addition to IGF1R, IGFBP7 has been shown to bind v3 (50), type IV collagen (66), and heparin sulfate (67). The functional outcome of these interactions is not well understood, but given the adhesion nature of these molecules because of carbohydrate involvement (68,69), a proposed role of these interactions may be to retain IGFBP7 protein in the ECM. ...
... Here It is important to note that CS polysaccharides present within the library (and indeed present naturally) are not exclusively pure CS-A or CS-C polymers, but contain variable amounts of 6-O-sulfation or 4-O-sulfation, respectively. 17,18 The second principal component appears to accord with the degree of sulfation (DoS), orthogonal to the GlcN and GalN regions. Again, unsulfated HA resides at the top, with sulfated samples descending toward Hp, which possesses an average DoS of 2.3. ...
... This feature is similar to the IGFBP7 gene, a member of the IGFBP superfamily responsible for the viability of insulin-like growth factors (IGFs) that are molecules involved in promoting cell growth and division [51]. This gene also acts as an oncosuppressor in prostate, breast, lung, and colorectal cancer due to its regulatory action related to cell proliferation, cell adhesion, cell senescence, and angiogenesis [52][53][54]. One of the main challenges of gigantism is the suppression of tumors due to a large number of cells. ...
... Matriptase, which cleaves substrates with Arg or Lys at the P1 position, has been incriminated in invasion and metastasis of breast cancer (48)(49)(50)(51). The action of proteolytic cleavage, specifically located at the N-terminus, including the heparin-binding motif, decreases heparin-binding and the occupancy of IGF-1R (48,52,53). ...
