Kazuyuki Kobayashi's research while affiliated with Kobe University and other places
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Publications (129)
The newly developed portable oxygen concentrator with an auto-demand oxygen delivery system (auto-DODS) automatically switches between 3 sensitivities according to the negative pressure gradient of inhalation and supplies oxygen only during inhalation. The aim of this study was to verify the effectiveness and safety of auto-demand devices compared...
Objectives : Several studies have reported that oropharyngeal myofunctional therapy (OMT) reduces the severity of obstructive sleep apnea (OSA). However, because OMT protocols are often complicated, they take time and effort to implement. The aim of this study was to determine the therapeutic effect of 8 weeks of simple tongue strength training wit...
Background
Skin disorders are the most common side effect associated with epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) therapy. It is important to manage skin lesions. Adapalene has been used to treat skin lesions caused by EGFR‐TKIs in some cases. The aim of this study was to investigate the functional mechanism of adapale...
Background
We have identified and reported a novel antigen, nonprotein‐specific secreted EP1‐like glycoprotein (51 kDa), for lettuce‐related respiratory allergy.
Objective
We aimed to identify a novel antigen for lettuce‐related respiratory allergy that is different from epidermis‐specific secreted EP1‐like glycoprotein.
Methods
Immunoblotting wa...
High-flow nasal cannulas (HFNCs) have become common devices for patients with respiratory failure who are treated in general wards. Few reports have been published on in-hospital mortality associated with the ratio of oxygen saturation (ROX) index, measured by pulse oximetry/fraction of inspired oxygen to respiratory rate, in patients treated with...
Cholinergic urticaria (CholU) is classified into several subtypes: (1) conventional sweat allergy-type CholU (conventional SAT-CholU), (2) CholU with palpebral angioedema (CholU-PA), 3) CholU with acquired anhidrosis and/or hypohidrosis (CholU-Anhd); 1) and 2) include SAT based on pathogenesis. There have been no studies on differences in the preva...
Background:
The desired depth of sedation during flexible bronchoscopy is one in which verbal contact is possible whenever necessary. Although it is common that the depth of sedation is assessed by validated instruments such as the modified observer's assessment of alertness and sedation (MOAA/S) score, the repeated stimulation associated with the...
Objectives
Oral corticosteroids reduce the antibody titer of the BNT162b2 mRNA vaccine against SARS-CoV-2. To date, the effect of inhaled corticosteroids on antibody titers is unknown.
Study design
The design of this study is retrospective study.
Methods
We analyzed the relationship between the clinical features and total antibody titers against...
Background
Chronic obstructive pulmonary disease (COPD) is a health problem that results in death, commonly due to the development of pulmonary hypertension (PH). Here, by utilizing a mouse model of intratracheal elastase-induced emphysema that presents three different phases of COPD, we sought to observe whether budesonide/glycopyrronium/formotero...
Non-small-cell lung cancer (NSCLC) is a major health burden, and novel therapeutic options are needed to help solve this problem. One such option is immunotherapy, which targets immune checkpoint molecules that inhibit cancer cells, decreasing immune system activation, for example, immunotherapies target PD-1, its ligand PD-L1, and CTLA-4. There ha...
Abstract Background Bronchoscopy can be a distress for the patient. There have been few studies on the combination of sedatives and opioids. The aim of this study was to demonstrate the usefulness and safety of administration of the combination of midazolam and pethidine during bronchoscopy. Methods In this prospective randomized single (patient)-b...
Background/aim:
The gut microbiome plays an important role in the immune system and has attracted attention as a biomarker of several diseases, including cancer. In this study, we examined the relationship between the gut microbiome and lung cancer progression.
Patients and methods:
Female never-smokers diagnosed with lung adenocarcinoma were co...
Background/aim:
Annexin A10 (ANXA10) is a member of the annexin family and a calcium-dependent phospholipid-binding protein. The aim of this study was to clarify the clinical significance of ANXA10 expression in lung adenocarcinoma.
Materials and methods:
ANXA10 expression was immunohistochemically examined in surgical specimens of lung adenocar...
Simple Summary
Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) was first reported in 2007. Following the development of crizotinib as a tyrosine kinase inhibitor (TKI) targeting ALK, the treatment of advanced NSCLC with ALK-rearrangements has made remarkable progress. Currently, there are five ALK-TKIs approved by the...
Background:
Bronchoscopy can be a distress for the patient. There have been few studies on the combination of sedatives and opioids. The aim of this study was to demonstrate the usefulness and safety of administration of the combination of midazolam and pethidine during bronchoscopy.
Methods:
In this prospective randomized single (patient)-blind st...
Background/aim:
Chloride intracellular channel 1 (CLIC1) is a member of the chloride channel protein family. The aim of this study was to clarify the role of CLIC1 in lung adenocarcinoma.
Patients and methods:
The expression levels of CLIC1 in 74 patients with completely resected lung adenocarcinoma were analyzed by immunohistochemistry. Overall...
Background
Nocturnal desaturation is common in patients with chronic obstructive pulmonary disease (COPD) and impacts disease exacerbation and prognosis. In our previous study, we developed a diagnostic algorithm to classify nocturnal desaturation from SpO 2 waveform patterns based on data from patients receiving home oxygen therapy. In this study,...
Background
Cholinergic urticaria (CholU) is classified into several subtypes: 1) conventional sweat allergy-type CholU (conventional SAT-CholU), 2) CholU with palpebral angioedema (CholU-PA), 3) CholU with acquired anhidrosis and/or hypohidrosis (CholU-Anhd), and other rare type; 1) and 2) include SAT based on pathogenesis. There have been no studi...
Objective Nocturnal desaturation is common in patients with chronic respiratory disease and often worsens the prognosis. Therefore, it should be diagnosed accurately and appropriately treated. The aim of this study was to clarify the diversity of nocturnal desaturation.
Methods We prospectively enrolled 58 outpatients diagnosed with chronic respira...
Background: Cholinergic urticaria (CholU) is classified into several subtypes: 1) conventional sweat allergy-type CholU (conventional SAT-CholU), 2) CholU with palpebral angioedema (CholU-PA), 3) CholU with acquired anhidrosis and/or hypohidrosis (CholU-Anhd); 1) and 2) include SAT based on pathogenesis. There have been no studies on differences in...
Introduction:
: When using portable oxygen, a demand oxygen delivery system (DODS), which senses the beginning of inhalation and delivers a bolus of oxygen, is often used. However, conventional DODS may not supply sufficient oxygen when reduced tidal flow fails to trigger the flow sensor. Recently, "auto-DODS," which detects the negative pressure...
Purpose
Sleep-disordered breathing is recognized as a comorbidity in patients with idiopathic pulmonary fibrosis (IPF). Among them, nocturnal hypoxemia has been reported to be associated with poor prognosis and disease progression. We developed a diagnostic algorithm to classify nocturnal desaturation from percutaneous oxygen saturation (SpO 2 ) wa...
Objective Bronchial thermoplasty (BT) is a bronchoscopic procedure for patients with severe asthma. Although it has been suggested that BT works by reducing airway smooth muscle, the detailed mechanism underlying its effects is still unknown.
Methods We performed xenon ventilation computed tomography (Xe-CT) before each BT procedure and six weeks a...
Objective evaluations of cough frequency are considered important for assessing the clinical state of patients with respiratory diseases. However, cough monitors with audio recordings are rarely used in clinical settings. Issues regarding privacy and background noise with audio recordings are barriers to the wide use of these monitors; to solve the...
A seventy‒year‒old man complaining of left arm weakness and gait disturbance was diagnosed with multiple tumors and severe edema in the brain as well as right lung mass lesion, suggesting brain metastases. He started whole brain radiation therapy but had to discontinue it since his neurological symptoms were worsened including paralysis, aphasia, a...
Asthma is a chronic disease with major public health ramifications owing to its high morbidity and mortality rates, especially in severe and recurrent cases. Conventional therapeutic options could partially alleviate the burden of asthma, yet a novel approach is needed to completely control this condition. To do so, a comprehensive understanding of...
Background: The gut microbiome plays an important role in the immune system and has attracted attention as a new biomarker of various diseases, including cancer. As such, in this study, we examined the relationship between the gut microbiome and lung cancer progression. In addition, we assessed the correlation between the gut microbiome and epiderm...
Background
Objective evaluations of cough frequency are considered important for assessing the clinical state of patients with respiratory diseases. While cough monitors with audio recordings are used in research settings, they are rarely used in clinical settings. Issues regarding privacy and background noise (especially the sounds of someone else...
Background
Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in lung adenocarcinomas are still unknown.
Methods
The expression levels of SERPINE2 in 74 consecutively resected lung adenocarcinomas were analyzed by using immunostaining....
Background: The gut microbiome plays an important role in the immune system and has attracted attention as a new biomarker of various diseases, including cancer. As such, in this study, we examined the relationship between the gut microbiome and lung cancer progression. In addition, we assessed the correlation between the gut microbiome and epiderm...
Background: The gut microbiome plays an important role in the immune system and has attracted attention as a biomarker of various diseases, including cancer. As such, we examined the relationship between the gut microbiome and lung cancer progression. In addition, we assessed the correlation between the gut microbiome and epidermal growth factor re...
The gut microbiome plays an important role in the immune system and has attracted attention as a biomarker of diseases, including cancer. As such, in this study, we examined the relationship between the gut microbiome and lung cancer progression. Female never-smokers diagnosed with lung adenocarcinoma were consecutively enrolled between May 2018 an...
Introduction
Various types of inhalation devices have been released, and it is necessary to acquire the skills for using each of them. The factors that have been previously associated with poor inhalator usage include gender, duration of disease, age, and the type of device. However, it is unclear whether these factors also apply to the Japanese po...
Purpose
Caspase recruitment domain-containing protein 9 (CARD9) is expressed at high levels in bone marrow cells and has a crucial role in innate immunity. Current studies indicate that CARD9 also plays a key role in tumor progression, but there are few reports on the role of CARD9 in lung cancer. The aim of this study was to clarify the role of CA...
The cover image is based on the Original Article Occupational respiratory allergy to lettuce in lettuce farmers by Reina Sekiya et al., https://doi.org/10.1111/cea.13682.
Background: Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in lung adenocarcinomas are still unknown.
Methods: The expression levels of SERPINE2 in 74 consecutively resected lung adenocarcinomas were analyzed by using immunostaining...
Background: Recent studies have revealed that serpin peptidase inhibitor clade E member 2 (SERPINE2) is associated with tumorigenesis. However, SERPINE2 expression and its role in non-small cell lung cancer are still unknown.
Methods: The expression levels of SERPINE2 in 74 consecutively resected lung adenocarcinomas were analyzed by using immunost...
Background
Cisplatin (CDDP) and vinorelbine as an adjuvant chemotherapy improve the overall survival of patients with completely resected non‐small cell lung cancer (NSCLC). However, the treatment completion rate is low due to severe adverse events (AEs). Pemetrexed (PEM) has been used in advanced NSCLC due to its high safety and efficacy. Addition...
Recently, the microbiome has been gaining traction as a major player regulating various functions that correlate with many pathological conditions, including cancer. The central gut microbiota population has the capability to regulate normal inflammatory, immune, and metabolic functions, and disturbance in the balance of the normal microbiota popul...
Background
Lettuce‐associated respiratory allergy has never been reported before. The aim of this study was to clarify the clinical condition of lettuce‐associated respiratory allergy and to identify the lettuce antigen which induces allergic symptoms.
Methods
We distributed questionnaires to 1,168 lettuce farmers and performed medical examination...
Asthma is an important issue not only in health but also in economics worldwide. Therefore, asthma animal models have been frequently used to understand the pathogenesis of asthma. Recently, in addition to acquired immunity, innate immunity has also been thought to be involved in asthma. Among innate immune cells, group 2 innate lymphoid cells (ILC...
Background:
It has not been determined that demand valve oxygen therapy is effective for nocturnal hypoxia. A portable oxygen concentrator with an auto-demand oxygen delivery system (auto-DODS; standard, high, and extra high) has recently been developed to improve oxygenation and comfort. This oxygen concentrator can supply a pulsed flow when it d...
Introduction:
Long-term oxygen therapy is reported to improve hypoxemia and survival in patients with respiratory failure. The demand oxygen delivery system (DODS) saves oxygen and extends the usable time of an oxygen cylinder 2- to 3-fold. A portable oxygen concentrator with an auto-DODS has been developed to switch its sensitivity among 3 levels...
Adenosine is involved in a range of physiological and pathological effects through membrane-bound receptors linked to G proteins. There are four subtypes of adenosine receptors, described as A1AR, A2AAR, A2BAR, and A3AR, which are the center of cAMP signal pathway-based drug development. Several types of agonists, partial agonists or antagonists, a...
Purpose
Adjuvant chemotherapy with cisplatin (CDDP) plus vinorelbine is the standard regimen for the treatment of non-small cell lung cancer (NSCLC). However, CDDP elicits severe toxic effects, including emesis, neurotoxicity, and renal damage; carboplatin (CBDCA) may be a feasible alternative for CDDP-unfit patients. CBDCA plus paclitaxel (PTX) ad...
Pulmonary lymphangioleiomyomatosis accounts for the majority of cadaveric lung transplantation cases. Post-transplantation management is continuingly necessary not only to prevent the progression of LAM but also to address complications. A woman with lymphangioleiomyomatosis underwent cadaveric lung transplantation. She developed post-operative nat...
A 51-year-old man underwent second-line treatment for non-small-cell lung cancer (NSCLC) with the immune checkpoint inhibitor (ICI) pembrolizumab. On day 2 after two cycles of pembrolizumab, he presented with edema limited to the left third, fourth, and fifth fingers. Based on symptoms, laboratory results, and contrast-enhanced magnetic resonance i...
Purpose
Pseudo-progression (PsPD) is a rare phenomenon observed in <5% of cases of non-small cell lung cancer (NSCLC). This event is challenging for both clinicians and patients. Viable biomarkers to distinguish between PsPD and true progressive disease (TPD) are lacking. The aim of our study was to determine the correlation between PsPD and the ne...
We herein report the case of a 39-year-old Japanese female with eosinophilic pneumonia associated with natalizumab. The patient with bronchial asthma had multiple sclerosis and was treated using natalizumab. The patient was referred to our department because of a persistent cough. A chest computed tomography (CT) scan revealed bilateral patchy cons...
Smoking causes various diseases and is a major public health threat worldwide. Therefore, promoting smoking cessation is the most important intervention contributing to maintaining the health of smokers and nonsmokers and saving enormous financial expense. We reviewed existing and emerging smoking-cessation pharmacotherapies from the Cochrane Datab...
Background
Nanoparticle albumin-bound paclitaxel (nab-PTX) plus gemcitabine (GEM) significantly improved overall survival in patients with metastatic pancreatic adenocarcinoma. Anti-tumor synergy between GEM and nab-PTX was recently demonstrated in a mouse model. We planned to assess the efficacy and safety of the combination of nab-PTX + GEM in pa...
Extracellular vesicles (EVs) are circulating vesicles secreted by various cell types. EVs are classified into three groups according to size, structural components, and generation process of vesicles: exosomes, microvesicles, and apoptotic bodies. Recently, EVs have been considered to be crucial for cell-to-cell communications and homeostasis becau...
Background: The combination of gemcitabine (GEM) and paclitaxel (PTX) was appealing for clinical exploration due to different mechanisms of action and partially non-overlapping toxicities.
Purpose: The aim of this study was to elucidate a potential effect of this combination on the proliferation of two non-small cell lung cancer (NSCLC) cell lines,...
Lessons learned:
The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect. Therefore, adapalene is not recommended as prophylaxis against acne-like rash induced by anti-epidermal growth factor receptor th...
Aim:
The aim of this study was to identify factors affecting the final diagnosis of cough.
Materials and methods:
This study recruited 463 consecutive patients who visited five Japanese general hospitals due to cough from October 2006 to September 2007. Of these, 418 patients (90%) who completed a questionnaire designed to acquire data regarding...
Transformation to small cell lung cancer is one phenomenon of acquired resistance to anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in ALK rearrangement‐positive non‐small cell lung cancer (NSCLC). Few case reports have focused on other types of histological transformation. We report a case of transformation of ALK rearrangement‐positi...
In developed countries such as North America, the decline in mortality from bronchial asthma has ceased since 2006. The decline in mortality rate is also decreasing in Japan, where about 1,500 asthma deaths have been reported. Among these, elderly people aged 65 years or over account for about 90% of cases. Therefore, the treatment of elderly patie...
Background/Aim: Immune checkpoint inhibitors (ICI) are a novel medication for non-small cell lung cancer (NSCLC). Recent reports indicated that baseline tumor size (BTS) relates to the efficacy of ICI therapy for melanoma, but no study exists for NSCLC. This study aimed to evaluate the utility of BTS for ICI therapy. Patients and Methods: Data from...
We present the case of a 70‐year‐old man with stage IV lung adenocarcinoma. He was treated with pembrolizumab, a programmed cell death‐1 (PD‐1) inhibitor, as a first‐line therapy. After six cycles of pembrolizumab, he suddenly developed cardiac tamponade. With the exception of newly massive malignant pericardial effusion, the other malignant lesion...
Abstract Background We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and inflammation-associated carcinogenesis by augmenting proinflammatory cytokine production from epithelial cells of various organs. The purpose of this study is to analyze its role in neutrophilic alveolar...
Hypertrophic pulmonary osteoarthropathy (HPO) is a paraneoplastic syndrome characterized by digital clubbing, arthritis, and periostitis. Tumor removal usually leads to the resolution of these symptoms. We herein report the efficacy of crizotinib treatment for treating the symptoms of HPO associated with c-ros oncogene 1 receptor tyrosine kinase (R...
Background/aim:
Red cell distribution width (RDW) has been reported to reflect the inflammation and nutrition status and predict prognosis of non-small cell lung cancer (NSCLC) patients treated with anti-programmed cell death-1 (PD-1) antibody. The aim of this study was to analyze the correlation between RDW and prognosis of NSCLC patients.
Patie...
Cough-variant asthma is one of the most common reasons for chronic cough. It is important to treat appropriately cough-variant asthma because 30% to 40% of cough-variant asthma becomes a typical asthma. However, little is known about the treatment of cough-variant asthma except for inhaled corticosteroid (ICS). The aim of this study was to validate...
Background
Sphingosine kinase phosphorylates sphingosine to generate sphingosine 1 phosphate (S1P) following stimulation of the five plasma membrane G-protein-coupled receptors. The objective of this study is to clarify the role of S1P and its receptors (S1PRs), especially S1PR3 in airway epithelial cells.
Methods
The effects of S1P on asthma-rela...
A hierarchical cluster analysis was performed with Pearson’s correlation coefficient using log2 ratio data.
(XLSX)
Objectives:
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (i.e., EGFR-TKIs) improve the survival of lung cancer patients harboring EGFR mutations. Despite the initial efficacy of EGFR-TKIs, the disease progression caused by acquired resistance to these inhibitors is inevitable. T790M mutations represent a major resistance mech...
Hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) syndrome is an autosomal dominant condition caused by mutations of the gene encoding the dual zinc-finger transcription factor, GATA3. A previous study identified some patients with GATA3 gene variants and breast cancer, suggesting that GATA3 variants may contribute to tumorig...
Background
Nivolumab improves the survival of advanced non-small cell lung cancer (NSCLC), but a significant number of patients still fail to benefit from this treatment. In this study, we evaluated the efficacy of the time-series behavior of neutrophil-to-lymphocyte ratio (NLR) in a complete blood count from advanced NSCLC patients as a predictive...
A 20-year-old Japanese woman with a history of pulmonary atresia was referred to our hospital after the detection of an abnormal mass in the right lung and mediastinal lymphadenopathy. A cytological specimen obtained by transbronchial brushing indicated that the pathological diagnosis was non-small cell lung cancer. During the follow-up period, the...
A 62-year-old male with lung adenocarcinoma harboring an exon 19 deletion in the EGFR was treated with EGFR-TKIs and several cytotoxic agents. After administering a fifth-line chemotherapy regimen, a liver biopsy revealed a diagnosis of recurrence with a T790M mutation. After an 82-day course of osimertinib therapy, the patient developed osimertini...
Background/aim:
Amrubicin (AMR) has shown promising activity for lung cancer. However, little is known about the mechanism underlying resistance to this agent. The aim of this study was to elucidate the mechanism underlying resistance to AMR.
Materials and methods:
We first developed amrubicinol (AMR-OH)-resistant cell lines (H520/R and DMS53/R)...
In pathway-targeted cancer drug therapies, the relatively rapid emergence of drug-tolerant persisters (DTPs) substantially limits the overall therapeutic benefit. However, little is known about the roles of DTPs in drug resistance. In this study, we investigated the features of EGFR-TKI induced DTPs and explored a new treatment strategy to overcome...
Objective:
Endobronchial ultrasonography and guide sheath (EBUS-GS) technique has high diagnostic yield in lung nodules. Virtual bronchoscopic navigation (VBN) can lead bronchoscope to the target bronchi. The aim of this prospective study was to compare the diagnostic yield of two bronchoscopic procedures: bronchoscopy under EBUS-GS and VBN with o...
Background. Bronchoaspiration of a foreign body is rare in adults. Adult bronchoaspiration patients often develop minor symptoms. Therefore, it takes time to diagnose them as having bronchoaspiration. We herein report an adult patient who aspirated a peanut in his bronchus with ABPA-like chest shadows. Case. A 69-year-old man presented to our hospi...
Background
Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that acts as a signal transducer by binding to S1P receptors (S1PR) 1 to 5. The S1P/S1PRs pathway has been associated with remodeling and allergic inflammation in asthma, but the expression pattern of S1PR and its effects on non-immune cells have not been completely clarified. The...
Background:
The demand for adequate tissue samples for both morphological assessment and molecular studies on lung cancer treatment has increased. The aim of this study was to evaluate whether cell blocks (CBs) prepared from endobronchial ultrasonography with guide sheath (EBUS-GS) rinsing following catheter aspiration provide additional informati...
We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap small GTPases, is expressed in bronchial epithelial cells, and plays an important role in T helper 2 cell-mediated airway inflammation with eosinophilic infiltration. The purpose of this study is to examine whether PLCε is involved also in the pathogenesis of neutrophil-mediated...
Background and objective:
Endobronchial ultrasonography with a guide sheath transbronchial biopsy (EBUS-GS TBB) has been used to diagnose peripheral pulmonary lesions (PPLs). In this study, we evaluated the diagnostic utility of conventional TBB after EBUS-GS TBB.
Methods:
A retrospective analysis of patients who underwent conventional TBB after...
In pathway-targeted cancer drug therapies, the relatively rapid emergence of drug-tolerant persisters (DTPs) substantially limits the overall therapeutic benefit. However, little is known about the roles of DTPs in drug resistance. The aim of this study is (1) to clarify the subpopulations of DTPs in EGFR mutated non-small lung cancer (NSCLC) cells...
Background. Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are key drugs for patients with EGFR mutations. However, the therapeutic management of EGFR-TKI-induced eruptions is sometimes challenging. Case 1. A 47-year-old man was diagnosed with advanced lung adenocarcinoma (cT4N3M1b, stage IV) harboring an exon 19 deletion o...
Background:
Phospholipase Cε (PLCε) is an effector of Ras and Rap small GTPases and expressed in non-immune cells. It is well established that PLCε plays an important role in skin inflammation, such as that elicited by phorbol ester painting or ultraviolet irradiation and contact dermatitis that is mediated by T helper (Th) 1 cells, through upregu...
We report the case of a 70-year-old Japanese male diagnosed with advanced lung adenocarcinoma harboring the echinoderm microtubule-associated
protein-like 4-anaplastic lymphoma kinase fusion gene. As soon as crizotinib was administered, tumor shrank immediately. On
Day 25, he developed interstitial lung disease. Bronchoalveolar lavage fluid analysi...
Objective:
To elucidate the actual condition of asthma treatment in emergency settings.
Methods:
A questionnaire survey on the situation of emergency care was conducted on 175 medical institutions providing either secondary or tertiary emergency care in Hyogo Prefecture during a 1-year period starting in April 2010. Data were investigated for ea...
Objective:
Adverse skin reactions as a local side effect of nicotine patches sometimes interfere with smoking cessation therapy. We studied the effects of semipermeable membrane dressings (SMD) used under nicotine patches (NP) on nicotine absorption, as assessed according to the urinary cotinine levels, and skin symptoms.
Methods:
First, the uri...
The purpose is to examine the synergistic effect of pemetrexed (PEM) and amrubicin (AMR) on the proliferation of lung cancer cell lines. In vitro, dose-dependent synergistic effects of concurrent PEM and AMRol, which is an active metabolite of AMR were observed in A549 and H460 cells. In real-time RT-qPCR analysis and western blotting, expression o...
ImagingSESSION TYPE: Original Investigation SlidePRESENTED ON: Sunday, October 27, 2013 at 10:45 AM - 11:45 AMPURPOSE: To compare CAD as concurrent reader (cCAD) and CAD as second reader (sCAD) for lung nodules on CT in terms of reading time and observer performance when using prototype CAD software.METHODS: Thirteen observers consisting of 7 radio...
Early detection of changes in respiratory function in smokers is important for the prevention of chronic obstructive pulmonary disease (COPD). The objective of this study was to investigate any changes in the respiratory impedance of smokers with normal FEV1/FVC.
We assessed and compared the impedance components, respiratory resistance, and reactan...
The aim of this study was to prospectively examine the effect of prophylactic antibiotic use on the development of respiratory infections and on the worsening of symptoms after diagnostic fiberoptic bronchoscopy procedures. This study was an open-label, multicenter, controlled, clinical trial. Patients were alternately assigned to a group given pro...
PURPOSE
To explore difference between two viewing modes, where an observer is asked to primarily view axial images in one mode (A mode) and reformatted coronal images in the other mode (C mode), in computer-aided detection (CAD) for lung nodules on CT in terms of observer performance and reading time.
METHOD AND MATERIALS
Ten observers (6 radiolog...
The present study describes a case of a 60-year-old Japanese man who was histologically diagnosed with lung adenocarcinoma harboring L858R mutation of epidermal growth factor receptor. He was successfully treated with gefitinib, but eventually developed leptomeningeal carcinomatosis. He underwent ventriculoperitoneal shunting for hydrocephalus and...
Citations
... Patients in both groups were treated using a TCI-I injection pump (Beijing Oriental Chengyitong Technology Co., Ltd.) for TCI of propofol with an effect-site concentration (EC) of 3.0 μg/mL (Marsh model), followed by TCI of remifentanil (20A03171, Yichang Humanwell Pharmaceutical Co., Ltd., Minto model) at a Modified Observer's Assessment of Alertness/Sedation (MOAA/S: No response after painful trapezius squeeze is 0. Responds only after painful trapezius squeeze is 1. Responds only after mild prodding or shaking is 2. Responds only after loud and/or repeated demand is 3. Lethargic response to demand in normal tone is 4. Responds readily to demand in normal tone is 5) of 0 [19,20]. Rocuronium 0.6 mg/kg was administered after stabilizing the drug concentration. ...
... Station 4L LN involvement changed the pathological stage and remodeled the postoperative regimens, which temporarily influenced the DFS. However, overall survival still needs to be elevated in locally advanced and metastatic NSCLC, even with the rapid progress in immunotherapy and targeted therapy (21,22). ...
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... It was confirmed that NF-κB in macrophages lymphocytes, pulmonary artery endothelial cells and smooth muscle cells of pulmonary tissue increased activation in patients with idiopathic PH than those in normal controls. 25 Recent studies have been conducted using NF-κB inhibitors or specific blocks of NF-κB pathway in animal PH models found to be effective in slowing down PH progression and improved right ventricular remodeling. 8,26 p38-mitogen activated protein kinase (p38 MAPK) is a subgroup of the MAPK family. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/694976107261952-1542706624084_Q64/Gusti-Ryanto.jpg)
... Midazolam (1-3 mg) and pethidine (35 mg) were administered intravenously at doses that are commonly used in Japanese clinical practice to provide sedation before the start of the examination. This was followed by an additional 1 mg of midazolam to maintain moderate sedation during the examination [6][7][8]. When coughing occurred during the procedure, 2% lidocaine was repeatedly administered through bronchoscopic channels. ...
... Epidermal growth factor receptor (EGFR)-wild-type patients have abundant Bifidobacterium and FB, whereas Blautia was relatively low compared to the EGFR-mutated population. 57 It is difficult to determine whether these changes had occurred before or after the development of cancer. It has been demonstrated that Bacteroides and Faecalibacterium can individually upregulate T-cells in the cancer lesion, followed by inhibiting proliferative cells and can activate T reg cells, respectively. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/715607217545221-1547625464894_Q64/Koji-Hosomi.jpg)
... Annexins, including 12 family members, play a major role in the regulation of a broad range of physiological processes linked to cellular membranes [3]. Previous studies have revealed that the aberrant expression of ANXAs is frequently observed in various types of cancer, including cervical cancer [4], bladder cancer [5,6], breast cancer [7][8][9], gastric cancer [10], lung cancer [11,12], oral squamous cell carcinoma [13], hepatocellular carcinoma [14,15], and cholangiocarcinoma [16]. ANXAs may function as either oncogenes or suppressors depending on tumour biology. ...
... Chromosomal rearrangements encoding the anaplastic lymphoma kinase (ALK) gene in non-small cell lung cancer (NSCLC) can be detected in 3-8% of cases (Schneider et al. 2023). ALK tyrosine kinase inhibitors (TKIs) are the first-line therapy for the treatment of advanced NSCLC with ALK rearrangements (Fukui et al. 2022). Crizotinib was the first ALK-TKI to significantly improve patient prognosis. ...
... In lung adenocarcinoma, Wang et al. found that CLIC1 protein expression in the cancer tumors correlated with the tumor staging and overall survival [43]. It was consistent with the study by Yasuda et al. who found that high CLIC1 protein expression was associated with worse overall survival [24]. In vitro analyses showed that CLIC1 is involved in the p38/MAPK signaling pathway -knockdown of CLIC1 inhibited proliferation and migration of lung adenocarcinoma cells. ...
... Thus, the clinician may be forced to rely on home oximetry to try and determine whether OSA is present. While different patterns of oxygen desaturation have been described ( figure 4) with an "intermittent" pattern reported to be suggestive for OSA [88], studies overall have found relatively modest diagnostic value of home oximetry for detecting OSA [89,90]. At the same time, there may be harm for individuals with overlap syndrome who are prescribed nocturnal oxygen therapy and who will also not benefit from CPAP therapy. ...
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... In our previous study, we analysed nocturnal SpO 2 waveforms obtained from patients with chronic respiratory diseases receiving home oxygen therapy (HOT), and we showed that the SpO 2 waveforms were very diverse [7]. Then, we found that each waveform was composed of a combination of three desaturation patterns: intermittent pattern, sustained pattern and periodic pattern. ...
