Kazuo Yamagata's research while affiliated with Nihon University and other places

... Quercetin has the potential to improve blood vessel health by promoting vasodilation through enhanced endothelial function. This ability raises the possibility of advantages in blood pressure control and cardiovascular health promotion [26]. ...

... Over the past few years, numerous research teams have conducted cohort studies, meta-analyses, and systematic reviews that explore the link between the intake of polyunsaturated omega-3 fa y acids and neurodegenerative conditions, such as Alzheimer's and Parkinson's diseases and various forms of dementia, as well as cognitive impairment and decline [102][103][104][105]. Wei et al. [102] observed that long-term users of omega-3 supplements have a 64% reduced risk of developing Alzheimer's disease. ...

... The saturated fatty acids were classified as pro-atherogenic because they promote the adhesion of lipids to cells of the immune system, while the unsaturated fatty acids were classified as anti-atherogenic because they inhibit plaque aggregation while reducing the levels of esterified fatty acids, cholesterol and phospholipids, thus preventing the occurrence of coronary heart disease [14]. ...

... Indeed, the hypoxic conditions, related to ischemia, trigger several metabolic and electrolytic brain dysfunctions [79] as well as the release of various mediators, like the large production of reactive oxygen species (ROS), the lactate accumulation, the alteration of calcium homeostasis, the unbalance of potassium and sodium ions, the massive release of nitroxide. All these mediators supported the oxidative stress and provided the modification of macro environment [7,80,81], that caused the cell death during the ischemia [82][83][84]. In We previously demonstrated that CDP-choline/Lip, with a similar lipid composition, significantly decreased the damage associated to ischemic stroke in rodents and improved the recovery of brain performance after ischemia [19,54]. ...

... Soy and fava beans, green bean, kudzu root, and alfalfa sprouts [53] Preventing phosphorylation of JNK Activation of Akt /ERK 1,2 pathway [89] ↑ eNOS activity and blocking NADPH-stimulated ROS production Suppression of superoxide production and NOX4 expression ↓ MDA [90] ↓ CRP [53] ↓ TNF-α [82] Activation of PPARs and AMPK ↓ IL-6 [89] ↓ TG ↓ Cholesterol ↓ Visfatin ↓ LDL and ox-LDL ↑ HDL ↑ Adiponectin [53] ↑ β-oxidation of FA ↓ Lipogenesis Preventing de-novo lipid synthesis [89] Promotion of browning of white adipocytes [90] ↓ Insulin resistance [82] ↑ Proliferation of βcells [89] ↓ HbA1c ↓ Blood glucose [90] ↓ Blood pressure [53] ↓ Circulating ICAM ↓ Endothelial dysfunction [53] ↓ ET-1 NO production via PKA/eNOS/NO signaling ↑ Expression of E-selectin, P-selectin, MCP-1, and IL-8 [90] Carotenoids Fruits (tangerines, cantaloupes, papayas, and oranges) and vegetables (carrot, pumpkin, spinach, sweet potato, tomato, broccoli, and green peas) [53] ↓ Production of free radicals [91] Serve as precursors for retinol (vitamin A), retinaldehyde, and retinoic acid, among other substances; retinoid conversion products that play important roles as transcriptional regulators in the visual cycle and gene regulation link [92] Down-regulation of NF-κB and MAPK signaling pathways, Reducing the release of pro-inflammatory cytokines [93] ↑ Adiponectin ↓ Body weight ↓ Visceral fat ↓ Lipid storage ↓ LDL [53] ↓ TG ↑ HDL [91] Reversing cholesterol transport by HDL [93] ↑ Insulin sensitivity ↓ Insulin resistance [53] ↓ Blood glucose [91] ↓ Blood pressure [53] ↓ Endothelial dysfunction ↓ PAI-1 [53] Delay the progression of cardiovascular diseases ↑ NO bioavailability ↓ Accumulation of cholesterol in foam cells and the formation of atherosclerotic plaques [93] ...

... Lung carcinoma Cell line Prevent cancer formation through STAT phosphorylation with IFN-gamma [24]. ...

... They can prevent various chronic diseases because of including fucoxanthin, fucoidan, phlorotannin and astaxanthin. The components of seaweed provide protection against vascular endothelial dysfunction (Yamagata, 2021). Seaweeds are effective as therapeutic pharmacological assets for various disorders, including inflammatory, intestinal, cardiac, hypertension, cholesterol, obesity, dyslipidemia, cancer, rhinitis, woundhealing, osteoporosis, goitre, anaemia, gastrointestinal, thrombosis, asthma, gastric ulcers, blood coagulation, arthritis, detoxification, hormone, and diabetes. ...

... 60 Astrocytes have been shown to block damage caused by stroke and other diseases of the CNS, including suppression of synaptic damage and amelioration of synaptic dysfunction. 61 Astrocytes play a critical role in regulating synaptic remodeling after stroke. In a mouse model of focal cerebral ischemia, thrombospondin 1 and 2 (TSP-1/2) expression was significantly increased and colocalized mostly to astrocytes, whereas inhibition of TSP-1/2 expression reduced synaptic density and defective axon outgrowth (Figure 2), 62 which suggests that TSP-1/2 expression in reactive astrocytes exerts a protective effect on synapses. ...

... P = 2.79 × 10 −4 ). Considering prior publications indicating a relationship between DHA and stroke [9,31,32], we conducted a more detailed investigation into this factor. The DHA factor remained associated with incident stroke in sensitivity analyses in which models were further adjusted for statin use (HR = 0.89; 95%CI 0.83-0.95; ...

... OT was measured using a 96-plate commercial OT-ELISA kit (Enzo Life Sciences, Farmingdale, NY, USA), as described previously. 73 The optical density of the samples and standards was measured at wavelengths of 405 and 590 nm using a microplate reader (Bio-Rad, Richmond, CA, USA). Sample concentrations were calculated using Matlab, version 7 (MathWorks, Natick, MA, USA) according to the relevant standard curve. ...