Kazunori Urabe's research while affiliated with National Hospital Organization Kyushu Cancer Center and other places

... In the case of varicella due to reinfection by VZV of a different genotype, VZV-specific IgM potentially increases, whereas VZV-specific IgG appears to rapidly increase commonly from a certain level at an early time point from the onset. 11 In the case of varicella caused by primary VZV infection, VZV-specific IgM definitely increases, whereas VZVspecific IgG gradually becomes elevated over 2-3 weeks from a negative level. Increases in VZV-specific IgM were followed by a gradual elevation in VZV-specific IgG over 2 weeks from a negative level in the present case, which was compatible with primary VZV infection. ...

... [1,36,37] However, a small proportion of patients presented with integumentary signs prior to uveitis. [17,38,39] Some of these reported cases were a result of vitiliginous scarring caused by skin injuries (Koebner's phenomenon). [40,41] Vitiligo presents as smooth, nonitchy white opaque depigmented skin patches. ...

... Albeit rare, associations with HMs have been found for various granulomatous dermatoses, including granuloma annulare, cutaneous sarcoidosis, interstitial granulomatosis and palisaded neutrophilic granulomatous dermatitis. While these disorders present with different clinical and histological presentations, the subtypes of associated HMs are similar, and include Hodgkin's and non-Hodgkin's lymphoma, myelodysplastic syndromes and chronic myelomonocytic leukaemia [223][224][225][226][227][228][229]. Hodgkin's lymphoma is a unique example of a malignant tumour in which neoplastic cells account for less than 10% of the entire tumoural mass, while the remaining 90% is mostly composed of reactive lymphocytes and macrophages [230]. ...

... While rare, there have been isolated instances of adverse events, such as allergic reactions and reversible cranial parenchymal changes observed on MRI following coil embolization of cerebral aneurysms. 5,6 Metal allergy, notably nickel allergy, is relatively common, with a prevalence as high as 17% in women and 3% in men in the general population. 7 Consequently, some researchers have suggested that post-procedural events may be linked to the release of nickel ions into the bloodstream. ...

... 9,11,12 Moreover, it has also been established that IGF-IR fuels mTOR. 26,27 To validate whether AG-1024 enhances sorafenib sensitivity by regulating mTOR-related signaling pathway, a Western blot analysis together with the administrations of an mTOR inhibitor was performed. Although the mTOR expression level was significantly upregulated in both the combination and high-dose sorafenib groups, a considerable up-regulation of mTOR phosphorylation and p21 was only observed in the combination group. ...

... Previously reported treatments to include topical medications such as keratolytics and/or retinoids, sometimes used in combination with topical corticosteroids, a combination of a 1,450-nm diode laser and a 1,550-nm erbium-doped fiber laser, or surgical removal (Tchernev et al., 2013). Activated vitamin D3 ointment did not lead to improvement (Ito et al., 2013). Although there was previously reported successful treatment of nevus comedonicus with adapalene, it did not lead to an improvement in this patient (Mahran, Abdelsamea, & Mekkawy, 2017). ...

... We are aware of at least 20 different reports and abstracts of transient zinc deficiency in full-term breast-fed infants published in the past 8 y (2007-2014) in Japan (see Supplementary Table S1 online). Moreover, 17 case reports of this condition were presented in domestic Japanese pediatrics and dermatology journals between 1981 and 2006 (28). In all cases, zinc deficiency was attributed to low levels of zinc in the mother's breast milk, and symptoms were cured by zinc supplementation therapy and did not reoccur, which is typical for TNZD. ...

... Under normal physiological conditions, small amounts of oxygen are constantly converted into superoxide anions, hydrogen peroxide, and hydroxyl radicals. The biological activity of reactive oxygen species at a physiological concentration plays an important role in cell homeostasis and in a wide range of cellular parameters (proliferation, differentiation, cell cycle, and apoptosis) [5][6][7][8]. ...

... In the early stage, EMPD typically presents as a sharply demarcated, erythematous, eczematoid lesion. It occasionally presents as a depigmentation [15]. In the advanced stage, EMPD lesions become erosive and infiltrated, and eventually present as nodules [14]. ...

... In line with this assertion, we reviewed 12 case reports, and found that all cases (18 of 18 patients) with IBD were in remission or responding favorably to anti-TNF biologics when the psoriasis was first observed. [18][19][20][21][22][23][24][25][26][27][28][29] Apart from anti-TNF biologic-induced psoriatic skin lesions, in a small fraction of IBD patients, the underlying IBD is complicated by psoriasis. 14, 30 Denadai et al 14 found the incidence of psoriasis among IBD patients to be up to 11%, ...