Karan B. Bhanushali's research while affiliated with Roger Williams Medical Center and other places

... Catheter ablation with energy sources such as radiofrequency (RF) has been established as the standard of care for patients with symptomatic atrial fibrillation (AF) [1]. Catheter ablation is associated with a reduction in mortality in patients with coexisting heart failure with reduced ejection fraction; patients with symptomatic AF undergoing catheter ablation exhibit improved quality of life and improved freedom from atrial arrhythmias compared to medical therapy [1][2][3]. Pulmonary vein isolation requires safe and efficient transseptal puncture for left atrial (LA) catheterization. With the widespread use of RF ablation and transseptal puncture procedures, many developments have been made to assist operators, reduce procedural and fluoroscopy times, and reduce complications. ...

... Indeed, although the absence of statistically significant association with the falsification endpoints suggests the absence of concerns about post hoc data mining [23], only a randomized study specifically designed to investigate the possible effect of statin in reducing the risk of death in patients with breast cancer can provide a definitive answer to these open questions. Although statins have previously been shown to reduce the risk of cardiotoxicity associated with anthracyclines [18,24,25], this was not shown in our analysis. Instead, we found an increased risk of stroke and no significant difference in the risk of other cardiovascular events in statin users compared to statin non-users. ...