Kagne SR's research while affiliated with Dr. Babasaheb Ambedkar Marathwada University and other places

The search for a new antibiotic or antifungal that could function efficiently without side effects or inadequacies was always a dilemma. For centuries, mushrooms have been praised for their medicinal powers. Recent studies show that many mushroom species possess antimicrobial compounds that inhibit or kill bacteria, fungi, and other microbes. These studies attributed the antimicrobial potency of mushrooms to the presence of active compounds called phytochemicals. Mushrooms have been found to contain an abundance of phytochemicals such as phenolics, terpenoids, flavonoids, alkaloids, steroids, saponins, and polysaccharides. These compounds can inhibit cell wall synthesis and disrupt membrane permeability or redox balance. This review highlights the current knowledge about the phytochemical content of mushrooms, their antimicrobial properties, and some extraction strategies. The antimicrobial effects of various microorganisms, such as foodborne pathogens, drug-resistant bacteria, and fungi, are discussed. Critical limitations in using mushrooms as antimicrobial sources include safety risks from toxins, variability in compound potency between species, extraction and purification challenges, inconsistent yields, scalability issues, and regulatory hurdles for commercial applications. Overall, this article shows that mushrooms are prosperous of various antimicrobial compounds that can benefit human health.

Mushrooms are a valuable source of food and medicine that have been used for centuries in various cultures. They contain a variety of phytochemicals, such as terpenoids and polysaccharides, that exhibit diverse biological activities, such as antioxidant, anti-inflammatory, anticancer, antimicrobial, immunomodulatory, and antidiabetic effects. However, mushroom’s phytochemical composition and bioactivity vary depending on their species, cultivation conditions, processing methods, and extraction techniques. Therefore, using reliable analytical methods and standardized protocols is important for systematically evaluating the quality and quantity of mushroom phytochemicals and their therapeutic potential. This review provides a bibliometric analysis of the recent literature on biological activities, highlights trends in the field, and highlights the countries and journals with the highest contribution. It also discusses the nutritional value of the total content of phenolic and other phytochemicals in some species of mushrooms.

The growing interest in exploring mushrooms and their bioactive components as potential therapies for diabetes and inflammatory conditions has prompted our investigation. In this study, we examined the methanolic extract, as well as the petroleum ether and ethyl acetate fractions, derived from the fruiting bodies of Hypsizygus ulmarius and assessed the potential in vitro anti-inflammatory and anti-diabetic effects. The inhibition of salivary α-amylase, salivary sucrase, and α-glucosidase enzymes by the methanolic extract and its fractions was used to measure the level of antidiabetic activity. Further, the inhibitory effects of the enzymes lipoxygenase (LOX), cyclooxygenase (COX), and myeloperoxidase (MPO) were tested to assess the anti-inflammatory efficacy of the methanolic extract and its fractions. The fraction containing ethyl acetate has been demonstrated to have the highest level of in vitro antidiabetic effect, exhibiting IC50 values of 44.93, 27.70, and 44.75 μg/ml for salivary α-amylase, salivary sucrase, and α-glucosidase enzymes, respectively. Moreover, the fraction of ethyl acetate revealed the greatest in vitro anti-inflammatory action, with IC50 values of 25.67 μg/ml for LOX, 34.04 μg/ml for COX, and 38.71 μg/ml for MPO.

Since ancient people, mushroom have been used as a source of food and in therapeutic remedies. Many recent studies confirm different biological activities of mushrooms which include antioxidant, antimicrobial, anticancer, antidiabetic and anti-inflammatory activities. Many mushroom species have been evaluated for their antidiabetic and anti-inflammatory activities. This study highlights the effectiveness of mushrooms as antidiabetic and anti-inflammatory agents.

Mushrooms are known for their nutritional and medical values. The present study aimed to investigate antimicrobial activity of methanolic extract and its fractionation of Hypsizygus ulmarius (Bull.) fruiting bodies. Agar well diffusion method was used. The tested bacteria included Staphylococcus aureus (S. aureus), Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus (ATCC 25923) and Staphylococcus epidermidis (S. epidermidis) and one fungal species Candida albicans (C. albicans). Methanolic extract showed activity to S. aureus, MRSA and C. albicans while its fractions showed activity to S. aureus (petroleum ether fraction), S. aureus and MRSA (ethyl acetate fraction).