K H Tønnesen's research while affiliated with Bispebjerg Hospital, Copenhagen University and other places

... Coefficient of Tc-99m (0.153) is calculated using Tonnesen's formula. [11] GFR is calculated, in ml/min, as: 9.75621 × FU − 6.19843. Tc-99m DTPA is prepared in-house at our center, regular chromatography for labeling efficiency is performed, and radiochemical purity has consistently been shown to be over 95%. ...

... Conversely, when the perfusion pressure is low, a small decrease in perfusion pressure causes a much greater decrease in TcPO2 which may even reach 0 mmHg despite blood flow evidenced using other techniques [11]. Furthermore, it was pointed out that a null TcPO2 value did not indicate that no oxygen is reaching the tissue but rather that the oxygen delivery equals or exceeds the metabolic consumption of the skin [12]. ...

... Decades ago, attempts were made to directly reduce the procoagulant potential of blood plasma by defibrination. For this purpose, it was proposed to use ancrod, an enzyme from the venom of Calloselasma rhodostoma [63,64]. Created on the basis of this enzyme, the drug "Arvin" has been widely used in clinical trials [65]. ...

... In the early 1970s, KRISTERSSON et al. [44] were able to accurately predict the functional loss after pneumonectomy and lobecto- my [113]. TØNNESEN et al. [114] and subsequently ALI et al. [115] have confirmed these findings, the latter as long as the resection involved more than three segments. Since then, radiospirometry has been replaced by split perfusion scans using intravenous technetium-99 macroaggregate . ...

... This finding suggests that the proportional theory is correct and actual measurement or better estimation of femoral artery pressure would allow accurate predictions; in fact, this has been reported by one group in Scandinavia that used a proportional transmission formula. 10 The use of regularly sized cuffs is best in this regard but gives only slightly better than 80% accuracy. Although some of the predictive errors could be due to unexpectedly poor ABIs caused by unrecognized technical errors, most were probably due to poor TBI estimates caused by variable thigh girth. ...

... The Gates' method has been widely used because it is simple, convenient, noninvasive, repeatable and less time-consuming. The accuracy of this method is affected by many factors, such as ROI (6,7), renal depth (8)(9)(10)(11)(12), and net injection dose (13). From the Gates' formula we can find the accuracy of GFR also affected by the net counts of the kidneys. ...

... However, increasing the blood pressure in aged atherosclerotic patients is not devoid of risk in terms of cerebral bleeding, and an increase in sodium chloride in the diet may precipitate heart failure. This therapy has been restricted to ischaemic ulcers in young patients with Buerger's disease [49]. ...

... Successful recanalization of subacute (Ͼ2 weeks and Ͻ3 months) and chronic occlusions with thrombolytic therapy-usually in combination with angioplasty and stenting-in various arterial beds has increased awareness of the presence of varying degrees of organized clot components in these nonacute occlusions. 1,2 This clot component was implicated as a source of embolization after plain angioplasties 3 or postoperative occlusions, 4 and a number of interventions other than the time-consuming thrombolysis, including enclosed thrombolysis, 4,5 and mechanical thrombectomy using various devices 6 were used to address this issue. Although effective in removing acutely formed clots, the mechanical thrombectomy devices such as aspira-tion catheters 6 and mechanical thrombectomy catheters are considered to be unsuitable for removing subacute occlusions of more than 14 days' duration, because of the rapid organization and adherence of the clot to the arterial wall. ...

... Another important finding is that a lesion length ≥ 30 cm and a TASC II D lesion are predictors of primary patency loss. This finding is in contrast with one of the few previously published reports on the endovascular recanalization of the native SFA CTOs in patients with CLI after failed femoropopliteal bypass (Li et al. 2018), whose regression analysis had not shown significant influence of a lesion length > 20 cm and a TASC II D lesion on the primary patency loss, but it's in agreement with the historical and contemporary vascular literature on primary endovascular therapy for lower limb lesions (Jørgensen et al. 1991;Iida et al. 2014). In particular, 2017 ESC guidelines on the diagnosis and treatment of PAD (Aboyans et al. 2018) clearly state that if the occlusion/stenosis is > 25 cm, endovascular recanalization is still possible, but better long-term patency is achieved with surgical bypass, especially when using the great saphenous vein, although it does not distinguish between primary patency and secondary patency rates. ...

... A relationship between temperature and sleep stage is not entirely surprising, as body temperature is circadian and therefore linked with sleep-wake cycles. It is well established that heat is redistributed upon sleep onset, resulting in a decrease in core body temperature and a concomitant increase in peripheral temperature (Kräuchi, 2007;Sindrup, Kastrup & Jørgensen, 1991). Thermoregulation has been shown to be suppressed during REM sleep but not during NREM sleep (Adam, Tomeny, & Oswald, 1986). ...