Jung-Hyun Park's research while affiliated with Chungnam National University and other places
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Publications (340)
Teriparatide has been effective in treating people diagnosed with medication-related osteonecrosis of the jaw (MRONJ). However, its efficacy is not well established to be accepted as a standard of care. The objective of this paper was to investigate the efficacy of recombinant human parathyroid hormone for the treatment of MRONJ. We report three ca...
Energy-efficient operation and stable data retention are the key features of magnetic information devices. Simultaneous achievement of writing-energy reduction and data-stability enhancement has yet faced a dilemma, since both are subjected to the same governing mechanism of magnetization switching, and thus, it is not easy to reduce writing energy...
Recently, artificial exosomes have been developed to overcome the challenges of natural exosomes, such as production scalability and stability. In the production of artificial exosomes, the incorporation of membrane proteins into lipid nanostructures is emerging as a notable approach for enhancing biocompatibility and treatment efficacy. This study...
Background: The aim of this study was to evaluate the association of oral health status and habits with the occurrence of ankylosing spondylitis (AS) in a nationwide population-based cohort in a longitudinal setting. Methods: A total of 2,415,963 individuals aged 40–79 years who underwent oral health examinations were included from the National Hea...
The cytokine IL-7 plays critical and nonredundant roles in T cell immunity so that the abundance and availability of IL-7 act as key regulatory mechanisms in T cell immunity. Importantly, IL-7 is not produced by T cells themselves but primarily by non-lymphoid lineage stromal cells and epithelial cells that are limited in their numbers. Thus, T cel...
Acute myeloid leukemia (AML) is an aggressive malignancy characterized by rapid growth and uncontrolled proliferation of undifferentiated myeloid cells. Metabolic reprogramming is commonly observed in the bone marrow of AML patients, as leukemia cells require increased ATP supply to support disease progression. In this study, we examined the potent...
550
Background: Cholangiocarcinoma (CCA) is a malignancy associated with a poor prognosis. Gut microbiome dysbiosis is considered to be related with multiple disease, including and cancer. However, relationship between mucosal microbiome dysbiosis and CCA remains unclear. In this study, we evaluated mucosal microbiome of patients with extrahepatic-...
The occurrence of implant-associated osteonecrosis of the jaw (ONJ) has been reported in osteoporotic patients, particularly in association with bisphosphonate therapy. This study aimed to investigate the risk of implant surgery and implant presence for ONJ occurrence in osteoporotic patients longitudinally.
Based on Korean National Health Informat...
Acute myeloid leukemia (AML) is an aggressive malignancy characterized by rapid growth and uncontrolled proliferation of undifferentiated myeloid cells. Metabolic reprogramming is commonly observed in the bone marrow of AML patients, as leukemia cells require increased ATP supply to support disease progression. In this study, we examined the potent...
Background: Relapse is the major treatment failure of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. Especially, early relapse had seriously bad prognosis. And tumor-infiltrating T cells play an important role in disease progression and recurrence. However, there is lack of data about the marrow...
Magnetic domain-wall devices such as racetrack memory and domain-wall shift registers facilitate massive data storage as hard disk drives with low power portability as flash memory devices. The key issue to be addressed is how perfectly the domain-wall motion can be controlled without deformation, as it can replace the mechanical motion of hard dis...
Introduction
Medication‐related osteonecrosis of the jaw (MRONJ) is uncommon but can result in severe destruction of the jaw. This case–control study investigated the therapeutic effects of daily or weekly administration of teriparatide in the management of MRONJ using a cohort for osteonecrosis of the jaw.
Methods
Patients who were diagnosed with...
Background:
Far-infrared (FIR) irradiation has been reported to improve diverse cardiovascular diseases, including heart failure, hypertension, and atherosclerosis. The dysregulated proliferation of vascular smooth muscle cells (VSMCs) is well established to contribute to developing occlusive vascular diseases such as atherosclerosis and in-stent...
Innate CD8 T cells are proinflammatory effector T cells that achieve functional maturation in the thymus prior to their export into and maturation in peripheral tissues. Innate CD8 T cells produce the Th1 cytokine IFNγ but depend on the Th2 cytokine IL-4 for their generation. Thus, innate CD8 T cells can permute the intrathymic cytokine milieu by c...
Background
The aim of this study was to examine the longitudinal association between oral health parameters and osteoporotic fracture.
Methods
The study included participants who received oral health screening by dentists from the National Health Screening cohort database of Korea between 2003 and 2006. The primary outcome was osteoporotic fractur...
Autoimmune limbic encephalitis (LE) is a rare, but devastating complication of allogeneic hematopoietic stem cell transplantation (HSCT). There is currently limited evidence describing the risk factors, laboratory features, and underlying mechanisms of this neurologic adverse event. We retrospectively reviewed available clinical, imaging, and labor...
CD4⁺ T helper 17 (TH17) cells protect barrier tissues but also trigger autoimmunity. The mechanisms behind these opposing processes remain unclear. Here, we found that the transcription factor EGR2 controlled the transcriptional program of pathogenic TH17 cells in the central nervous system (CNS) but not that of protective TH17 cells at barrier sit...
Background
Periodontal disease can activate an immune process linked to systemic diseases, including atrial fibrillation. However, the relationship between periodontal disease and atrial fibrillation remains unclear.
Aim
This study aimed to investigate whether changes in periodontal disease status are associated with the risk of atrial fibrillatio...
Purpose:
This longitudinal cohort study aimed to evaluate the relationship between osteonecrosis of the jaw and pulp and periapical disease in patients who were administered bisphosphonates.
Methods:
Using data from a nationwide cohort, we examined the association among dental caries, pulp and periapical disease, and osteonecrosis of the jaw in...
Invariant natural killer T (iNKT) cells are thymus-generated innate-like αβ T cells that undergo terminal differentiation in the thymus. Such a developmental pathway differs from that of conventional αβ T cells, which are generated in the thymus but complete their functional maturation in peripheral tissues. Multiple subsets of iNKT cells have been...
Innate CD8 T cells correspond to a population of terminally differentiated effector T cells that phenotypically appear as antigen-experienced memory cells and functionally resemble proinflammatory CD8 T cells, expressing copious amounts of IFNγ. Innate CD8 T cells, however, are distinct from conventional effector-memory CD8 T cells as they acquire...
Autoimmune limbic encephalitis (LE) is a rare, but devastating complication of allogeneic hem-atopoietic stem cell transplantation (HSCT). There is currently limited evidence describing the risk factors, laboratory features, and underlying mechanisms of this neurologic adverse event. We retrospectively reviewed available clinical, imaging, and labo...
Background
Computer-aided design/manufacturing (CAD/CAM) technology was developed to improve surgical accuracy and minimize errors in surgical planning and orthognathic surgery. However, its accurate implementation during surgery remains a challenge. Hence, we compared the accuracy and stability of conventional orthognathic surgery and the novel mo...
The peripheral CD8 T cell pool comprises a mixture of naïve and memory-phenotype (MP) cells. While naïve CD8 T cells are continuously produced and supplied through thymic export, MP CD8 T cells are mostly generated by antigen activation or cytokine-mediated differentiation and maintained by homeostatic cytokines, such as IL-15. Both naïve and MP CD...
Invariant NKT (iNKT) cells are a small population of thymus-generated T lymphocytes with innate-like phenotype and function that play a disproportionally important role in immune regulation and surveillance. iNKT cells are generated upon strong agonistic TCR signaling by glycolipid-loaded CD1d molecules, which differs from conventional T cells that...
Background:
Resorption of alveolar bone is a common sequela of tooth loss and presents a clinical problem, especially in the esthetic zone. When ridge resorption occurs, adequate bone augmentation is essential to obtain satisfactory esthetic results. The purpose of this study was to determine the increase and retention rate of bone height or width...
Background: Biliary tract cancer (BTC) is an aggressive malignancy associated with a poor prognosis. Most BTC patients are diagnosed at an unresectable stage; further, the efficacy of cytotoxic chemotherapy for BTC remains unsatisfactory. Recently, there is growing evidence that gut microbial dysbiosis is related to multiple diseases, including bil...
Purpose:
In this study, we report the usefulness of implant placement with modified ridge splitting technique from three cases of patients with narrow alveolar ridge.
Materials and methods:
Three patients were those who visited the Department of Oral and Maxillofacial Surgery of Ewha Medical Center for consultation regarding implant placement. T...
Cell-penetrating peptides (CPPs) have great potential to deliver bioactive agents into cells. Although there have been many recent advances in CPP-related research, it is still important to develop more efficient CPPs. The development of CPPs by in silico methods is a very useful addition to experimental methods, but in many cases it can lead to a...
Nitric oxide (NO) is an important gaseous signaling molecule in various physiological processes, which functions through interactions with its acceptor molecules located in organelles. NO has an extremely short half-life, making it challenging to experimentally achieve effective NO levels in organelles to study these interactions. Here we developed...
Magnetic skyrmions [1,2] are a topologically stable spin configurations that are currently extensively studied as promising information carriers in spintronic devices [3-8]. When an electric current is injected, the skyrmions exhibit the skyrmion Hall effect [9,10]. This skyrmion Hall effect can be described by the Thiele equation [11-13]. Here, we...
Invariant natural killer T (iNKT) cells correspond to a population of thymus-generated T cells with innate-like characteristics and effector functions. Among the various iNKT subsets, NKT17 is the only subset that produces the proinflammatory cytokine IL-17. But, how NKT17 cells acquire this ability and what would selectively trigger their activati...
Periodontitis and rheumatoid arthritis (RA) are inflammatory diseases that share many similarities. We aimed to investigate the associations of periodontitis and oral hygiene status and behaviors with RA in a nationwide general population cohort. Participants from the National Health Screening cohort database of Korea who underwent oral health scre...
Objective
To investigate the association of oral health status and oral hygiene behaviors with cataract occurrence longitudinally.
Materials and methods
Based on the National Health Screening cohort database of Korea, participants who underwent oral health screening by dentists in 2003 were included. Cataract was defined as two or more claims of d...
To investigate the association of the oral health parameters with Meniere’s disease in a nationwide population-based longitudinal cohort database. The data of the participants who underwent an oral health screening by dentists in 2003 (n = 2,415,963) were retrieved from the National Health Insurance Database of the Korean National Health Insurance...
Oral health is reportedly associated with several systemic diseases, particularly cardiovascular diseases, through systemic inflammatory and thrombotic mechanisms. This study aimed to investigate the association between oral health status, oral hygiene behavior, and venous thromboembolism (VTE) in a nationwide, population-based cohort database in a...
Current-driven domain-wall motion is inevitably accompanied by tilting of the domain wall. There are two possible tilting mechanisms proposed either by the Oersted field or by the Dzyaloshinskii Moriya interaction (DMI). Here, we present the experimental observation that the DMI-induced mechanism plays decisive role in the domain-wall tilting for v...
The chemokine receptor CCR9 equips T cells with the ability to respond to CCL25, a chemokine that is highly expressed in the thymus and the small intestine (SI). Notably, CCR9 is mostly expressed on CD8 but not on CD4 lineage T cells, thus imposing distinct tissue tropism on CD4 and CD8 T cells. The molecular basis and the consequences for such a d...
Background:
We investigated whether periodontal diseases contribute to the development of medication-related osteonecrosis of the jaw (MRONJ) in addition to tooth extraction, which is a major risk factor for MRONJ occurrence.
Methods:
This retrospective, nationwide cohort study was performed using South Korea's National Health Insurance Service...
Objective:
The presence of periodontal disease (PD) at a single time point has been suggested as a predictor of diabetes risk, but whether changes in PD status are associated with altered risk of diabetes has yet to be reported on a population scale. This study investigated whether recovery from or development of PD in a population is associated w...
Valproic acid (VPA) has been used to treat epilepsy and bipolar disorder. Although the abnormal proliferation of vascular smooth muscle cells (VSMCs) is a well-established contributor to the development of various vascular diseases including atherosclerosis, the effect of VPA on VSMC proliferation and its mechanism of action have not been fully rev...
Lymphocytes in the mouse small intestine (SI) epithelium are critical to establish effective barrier immunity. Here, we describe a magnetic cell separation protocol that employs anti-epithelial cellular adhesion molecule (EpCAM) antibodies to deplete epithelial cells and to enrich for intraepithelial lymphocytes (IELs) from SI tissues. The resultin...
Understanding the homeostatic mechanism of invariant natural killer T (iNKT) cells is a critical issue in iNKT cell biology. Because interleukin (IL)-15 is required for the thymic generation of iNKT cells, IL-15 has also been considered necessary for the homeostasis of peripheral iNKT cells. Here, we delineated the in vivo cytokine requirement for...
Innate-like T (iT) cells comprise a population of immunoregulatory T cells whose effector function is imposed during their development in the thymus to provide protective immunity prior to antigen encounter. The molecular mechanism that drives the generation of iT cells remains unclear. Here, we report that the cytokine receptor γc plays a previous...
Background
A causal relationship of bisphosphonate (BP) exposure with osteonecrosis of the jaw (ONJ) has been reported; however, a definite dose-dependent risk remains to be elucidated beyond current vague recommendations of 4-year oral BP for ONJ risk increase.
Objective
To identify the effect of bisphosphonate cumulative dose on ONJ development...
Foxp3+ Tregs are potent immunosuppressive CD4+ T cells that are critical to maintain immune quiescence and prevent autoimmunity. Both the generation and maintenance of Foxp3+ Tregs depend on the cytokine IL-2. Hence, the expression of the IL-2 receptor α-chain (CD25) is not only considered a specific marker, but also a nonredundant requirement for...
Background
To determine whether capsular distention in the painful temporomandibular joint (TMJ) can be assessed by ultrasonography, we compared the capsular width between painful TMJs and painless TMJ. The risk factors for TMJ pain were also investigated including capsular width and other clinical factors such as TMJ sounds that may affect the occ...
Invariant NKT (iNKT) cells are potent immunomodulatory cells that acquire effector function during their development in the thymus. IL-17-producing iNKT cells are commonly referred to as NKT17 cells, and they are unique among iNKT cells to express the heparan sulfate proteoglycan CD138 and the transcription factor RORγt. Whether and how CD138 and R...
Balantioides coli is a zoonotic protozoan parasite whose main reservoir is pigs. Recent studies have shown that B. coli variant A but not B has zoonotic potential. While B. coli infection has been reported in different animals and countries, the prevalence of the zoonotic variant is limited due to a lack of molecular information. Therefore, this st...
In this prospective study, serum levels of 12 possible biomarkers were compared between osteonecrosis of the jaw (ONJ) and control groups, before and after dentoalveolar surgery. The results suggest that patients with abnormal serum levels of specific biomarkers should be monitored closely for the prevention and early diagnosis of ONJ.IntroductionB...
Background: Osteonecrosis of the jaw (ONJ) is one of the complication of bisphosphonate (BP). Despite being a major risk factor for ONJ, tooth extraction cannot explain all cases of ONJ. However, disease that induce inflammation in the jawbone, such as pulp and periapical disease is underestimated, and studies suggesting relationship are arising. T...
Evaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact line dynamics (pinned or slipping) and geometrical gr...
Integrin CD103 mediates the adhesion and tissue retention of T cells by binding to E-cadherin which is abundant on epithelial cells. Notably, CD103 is highly expressed on CD8 T cells but conspicuously absent on most CD4 T cells. The mechanism controlling such lineage-specific expression of CD103 remains unclear. Using a series of genetically engine...
To increase the half-life of growth hormones, we proposed its long-lasting regulation through the ubiquitin-proteasome system (UPS). We identified lysine residues (K67, K141, and K166) that are involved in the ubiquitination of human growth hormone (hGH) using ubiquitination site prediction programs to validate the ubiquitination sites, and then su...
Invariant NKT (iNKT) cells are thymus-generated innate-like T cells, comprised of three distinct subsets with divergent effector functions. The molecular mechanism that drives the lineage trifurcation of immature iNKT cells into the NKT1, NKT2, and NKT17 subsets remains a controversial issue that remains to be resolved. Because cytokine receptor si...
Far-infrared (FIR) irradiation is reported to inhibit cell proliferation in various types of cancer cells; the underlying mechanism, however, remains unclear. We explored the molecular mechanisms using MDA-MB-231 human breast cancer cells. FIR irradiation significantly inhibited cell proliferation and colony formation compared to hyperthermal stimu...
In the midst of resurging COVID-19 cases, the second NIH/FDA virtual COVID-19 and Cytokines symposium was held on 1 December 2020, focusing on longitudinal studies of COVID-19 immunity, including long-term consequences, potential associations with autoimmunity and the multisystem inflammatory syndrome in children (MIS-C). A central and ongoing ques...
Aims
Far-infrared (FIR) irradiation inhibits adipogenic differentiation of tonsil-derived mesenchymal stem cells (TMSCs) by activating Ca²⁺-dependent protein phosphatase 2B (PP2B), but it stimulates osteogenic differentiation in a PP2B-independent pathway. We investigated the potential involvement of transient receptor potential vanilloid (TRPV) ch...
Aphidicolin represses DNA replication by inhibiting DNA polymerase α and δ, which leads to cell cycle arrest and cell damage. Nitric oxide (NO) generated by endothelial NO synthase (eNOS) plays an essential role in maintenance of endothelial integrity including endothelial cell (EC) survival. Previously, we reported that aphidicolin increases NO pr...
Background:
This clinical case presented a novel method of segmental mandible reconstruction using 3D-printed titanium implant with pre-mounted dental implants that was planned to rehabilitate occlusion.
Case presentation:
A 53-year-old male who suffered osteoradionecrosis due to the radiation after squamous cell carcinoma resection. The 3D-prin...
Interfacial phenomena play decisive roles in modern science and technology as the scale of the material shrinks down to a few atomic layers. Such minute nanostructures require a more comprehensive understanding beyond the conventional concepts of interfaces and interfacial phenomena generated at interfaces. From a series of a few-atomic-layer-thick...
Assessing IL-2-induced phosopho-STAT5 (pSTAT5) content can reveal the cytokine responsiveness of individual T cells. Identifying distinct T cell subsets by nuclear transcription factors, such as Foxp3, and concurrently quantifying intracellular pSTAT5, however, has been technically challenging. Conventional Foxp3 staining buffers quench pSTAT5 sign...
Objective:
To compare postoperative positional changes in the mandibular proximal segment between the conventional orthognathic surgery (CS) and the surgery-first approach (SF) using intraoral vertical ramus osteotomy (IVRO) in patients with Class III malocclusion.
Methods:
Thirty-eight patients with skeletal Class III malocclusion who underwent...
Background:
Telmisartan, an angiotensin II type 1 receptor blocker (ARB), is widely used to treat hypertension by blocking the renin-angiotensin-aldosterone system. Although abnormal proliferation of vascular smooth muscle cells (VSMCs) is a well-established contributor to the development of various vascular diseases, such as atherosclerosis, the...
Objectives
To evaluate the effect of functional endoscopic sinus surgery (FESS) on the resolution of maxillary MRONJ (medication‐related osteonecrosis of the jaw).
Patients and Methods
This study included 62 patients diagnosed with MRONJ in the maxillary posterior area with or without maxillary sinusitis. All patients underwent oral surgery. The c...
“The role of cytokines in COVID-19” online symposium was presented on 18 June 2020 by the NIH/FDA Immunology and Cytokine Interest Groups and was purposed to discuss our rapidly changing understanding of COVID-19-related cytokine responses in different stages of infection, including the etiologies, downstream consequences and possible mitigation st...
IL-7 receptor signaling is essential for the generation and maintenance of conventional T cells. Immunosuppressive Foxp3⁺ Treg cells, however, express uniquely low amounts of the IL-7-proprietary IL-7Rα so that they are impaired in IL-7 signaling. Because Treg cells depend on IL-2, the loss of IL-7Rα has been considered irrelevant for Treg cells. I...
Zearalenone (ZEN) is a non-steroidal mycotoxin that has various toxicological impacts on mammalian health. Here, we found that ZEN significantly affected the production of nitric oxide (NO) and the expression of endothelial NO synthase (eNOS) of bovine aortic endothelial cells (BAECs). A promoter analysis using 5′-serially deleted human eNOS promot...
Although DNA damage responses (DDRs) are reported to be involved in nitric oxide (NO) production in response to genotoxic stresses, the precise mechanism of DDR-mediated NO production has not been fully understood. Using a genotoxic agent aphidicolin, we investigated how DDRs regulate NO production in bovine aortic endothelial cells. Prolonged (ove...
Lymphopenia-induced homeostatic proliferation (LIP) is a critical mechanism for restoring T cell immunity upon lymphodepleting insults or infections. LIP is primarily driven by homeostatic cytokines, such as IL-7 and IL-15, but not all T cells respond with the same efficiency to homeostatic proliferative cues. Although CD8 T cells vigorously prolif...
Key events in the pathogenesis of Sjӧgren syndrome (SS) include the change of salivary gland epithelial cells into antigen-presenting cell-like phenotypes and focal lymphocytic sialadenitis (FLS). However, what triggers these features in SS is unknown. Dysbiosis of the gut and oral microbiomes is a potential environmental factor in SS, but its conn...
SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor‐associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3‐interaction motif, and then binds JAK molecules to inhibit their kinase activity. The SOCS3‐interaction motif is found in receptor...
Here, we demonstrate an optical spin–orbit torque (SOT) measurement scheme that is free from artifacts such as the optic planar Hall effect (PHE) and the optic anomalous Nernst effect (ANE). Such PHE and ANE signals complicate the SOT analysis in the electrical harmonic measurement method. Our optical setup utilizes photoelastic modulation and bala...
Zbtb16 encodes the zinc-finger protein PLZF, which is often used as a lineage marker for innate-like T cells and is specifically required for the generation of invariant natural killer T (iNKT) cells in the thymus. Here, we report that not only PLZF expression itself but also the relative abundance of PLZF proteins plays critical roles in iNKT cell...
iNKT cell enrichment from C57BL/6 thymocytes by CD24+ cell depletion. (A) Enrichment of thymic iNKT cells from C57BL/6 mice by magnetic-activated depletion of CD24+ thymocytes. Dot plots (left) are representative, and graph (right) shows summary of 3 independent experiments. (B) Intracellular staining for PLZF vs. RORγt (top) and T-bet (bottom) sho...
MACS-mediated enrichment of thymic iNKT cells. (A) Percentages of iNKT cells in total thymocytes and in the MACS flow-through fraction. Plot shows summary of 5 independent experiments. (B) Surface TCRβ expression and CD1dTet staining on MACS-enriched or flow-through thymic iNKT cells. Histograms are representative of 5 independent experiments. (C)...
Invariant NKT (iNKT) cells are a small subset of thymus-generated T cells that produce cytokines to control both innate and adaptive immunity. Because of their very low frequency in the thymus, in-depth characterization of iNKT cells can be facilitated by their enrichment from total thymocytes. Magnetic-activated cell sorting (MACS) of glycolipid a...
Efficient electrical sorting of iNKT cells using CD24+ cell depletion. Thymic iNKT cells were pre-enriched by using CD24+ cell depletion ahead of electronic sorting. Frequency of iNKT cells were assessed before and after CD24+ cell depletion (left and middle), and enriched cells were used for electronic sorting of iNKT cells using flow cytometry (r...
Naïve and memory T cells co-exist in the peripheral T cell pool, but the cellular mechanisms that maintain the balance and homeostasis of these two populations remain mostly unclear. To address this question, here, we assessed homeostatic proliferation and repopulation kinetics of adoptively transferred naïve and memory T cells in lymphopenic host...
The point mutation that substitutes lysine with arginine at position 120 of human p53 has been characterized as a missense mutation. The K120R mutation renders the p53 protein disabled for acetylation and, as a result, defective for apoptotic function, which provides a mechanistic link between the missense mutation and tumorigenesis. However, we no...
Citations
... They cover the immunobiology of IL-7, from preclinical and clinical trials to the use of IL-7 recombinant proteins or IL-7 genes in cancer and infectious diseases. Through these studies, they present the current state and future prospects of IL-7-mediated immunotherapeutics (8). Lastly, Jonathan Sprent (Garvan Institute, Australia), and Onur Boyman (University of Zurich, Switzerland), who have made significant contributions to the field of CD8 T-cell immunity over the past decades, discuss anticancer immunotherapy via their beloved cytokine, IL-2. ...
... Although they may offer a larger tunable energy range, they require more complex fabrication techniques, and suffer from the same problem as the geometrical methods: the drive current pulses must be very precisely controlled. In a recent report 19 an error-free domain wall shift register was presented based on different principles. Here, regions with alternative net SOT signs were created, so that only when the applied current reverses, the domain wall progresses to the next section. ...
... Complex surgical approaches are frequently required for more severe cases [40]. Platelet-rich plasma concentrates (PRPs) [41,42] and recombinant human parathyroid hormone (Teriparatide) [43] are gaining attention as an adjunctive treatment in MRONJ management and prevention, by enhancing angiogenesis and osteoanabolic properties, among other effects. ...
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... While numerous publications have highlighted the significance of type I and III interferons in thymic biology [30], there is a noticeable paucity of information concerning the role of IFNg in the thymus despite the presence of various sources of this cytokine, such as thymic NKT1 cells, gd T cells and innate CD8 þ cells [3,31]. In this context, we investigated whether the IFNg expression observed in the thymi of T. cruzi-infected mice could contribute to some of the observed organ changes. ...
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... Periodontitis is a chronic inflammatory disease of the periodontium, which tend to ruin adjacent tooth tissues as the gingiva and the alveolar bone [1]. The loss of this bone, in fact, leads to a collapse of the underlying structure causing the loss of the tooth, which has effects in life's quality due to the masticatory dysfunction [2]. 2 Bad habits such as alcohol, smoking or poor oral hygiene give on to increase dental plaque, which is necessary, but not solely responsible, for triggering periodontitis [3]. The oral cavity harbors a unique microbial community comprising viruses, mycoplasmas, bacteria, fungi, and protozoa. ...
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... Additionally, our study observed that TREM-1 promotes cytokine secretion, induces iNKT cell dysfunction, and promotes IL-4 and IL-17 secretion in iNKT cells. Compared with CD4−iNKT, IL-4 and IL-17 secretion levels from CD4+iNKT cells are significantly higher [25,26]. Our research suggests that the activation of the TREM-1 signaling pathway in monocytes promotes the dysfunction of iNKT cells through the regulation of various cytokines and may participate in the process of CD4−/CD4+iNKT imbalance. ...
... Orthognathic surgery using virtual 3D surgical planning and CAD/CAM technologies is very accurate [42]. Its application in clinical practice has increased the predictability and comfort of surgery, and it will be important for clinicians to make continuous efforts to apply the most advanced technologies that will be developed in the future to patient diagnosis and surgery [43][44][45]. ...
... The proposed protocol allowed for the obtainment of a higher quantity of regenerated bone with a lower rate of graft remodeling, compared to conventional GBR [51]. Nevertheless, the sausage technique shows positive outcomes in the literature, yet the optimal indications to support its choice seem unclear [52][53][54][55]. The shape of the graft appears to depend on the tension of the membrane, and this may represent a partial limitation when the goal is to rebuild the buccal bone at the crestal level. ...
... In the second case, the mandibular left first molar was extracted simultaneously with ridge splitting and immediate implant placement on the first premolar and first premolar sites. The last report included ridge splitting and simultaneous implant placement for sites upper right first molar and second premolar [25]. Our case report represents a more challenging clinical situation because it is in the esthetic zone and the patient is fully edentulous. ...
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... However, the FCs were unable to achieve optimal results when evaluated individually, achieving accuracy between 74% and 88%, as well the extraction did not make it possible to discriminate the molecular descriptors with greater relevance in the classification [9]. Park et al. (2023) [23] developed a method for predicting CPPs based on DL called AiCPP with the aim of avoiding false-positive results, incorporating the LSTM algorithm. This work contributes to research into predictions of new CPPs with the discovery that short peptide sequences derived from amyloid precursor proteins are more efficient in permeating the cell membrane, despite not achieving the objective of reducing false-positive results in relation to other algorithms, with 88.6% accuracy against more than 90% of this metric achieved by other algorithms [23]. ...
