Jun Tan's research while affiliated with Guiyang Medical University and other places
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Publications (2)
Alzheimer's disease (AD), as the most common neurodegenerative disease in elder population, is pathologically characterized by β-amyloid (Aβ) plaques, neurofibrillary tangles composed of highly-phosphorylated tau protein and consequently progressive neurodegeneration. However, both Aβ and tau fails to cover the whole pathological process of AD, and...
Alzheimer's disease (AD) is the most common neurodegenerative disease in elderly population and the leading cause of dementia worldwide. While senile plaques and neurofibrillary tangles have been proposed as the principal histopathologic hallmarks of AD, the exact etiology of this disease is still far from being clearly understood. AD has been reco...
Citations
... Studies have shown that persons with AD, the most prevalent pathology in adults with dementia (65.3%), 5 and MCI have lower CVR compared to healthy older adults, [6][7][8] including a link between lower CVR and poorer cognitive performance. 9,10 Similarly, transgenic mice overproducing amyloid and transforming growth factor (TGF)-β1 developed an early progressive decline of cerebral arterial function and displayed arterial dysfunction unrelated to oxidative stress. ...
... The neuroticism personality showed genetic susceptibility to AD by exacerbating cognitive impairment (Zufferey et al., 2017), disturbing emotional fragility (Danielsdottir et al., 2019) and sleep difficulties (Stephan et al., 2020), which in turn makes people more susceptible to various cardiovascular diseases (Lee et al., 2022), all of which are high-risk factors for AD (Andrews et al., 2021;Korologou-Linden et al., 2019;Li et al., 2021;Stephan et al., 2018). Furthermore, neuroticism is an important risk factor for many psychiatric disorders, such as major depressive disorder and schizophrenia (Brainstorm The present study first provided correlations between N-PRS and brain structural phenotypes. ...
