Joy Choi's research while affiliated with University of Rochester Medical Center and other places
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Publications (10)
Objective:
Depression in patients undergoing coronary artery graft bypass (CABG) surgery is associated with morbidity and mortality, making its early identification and clinical management crucial. Vasculopathy and older age, hallmarks of patients requiring CABG, are also features of vascular depression. In this study, we assess for features of va...
Background:
Chronic cerebral hypoperfusion is a potential mechanism that causes cognitive impairment in patients with heart failure. Cognitive impairment in this population is associated with an increased mortality and poorer quality of life. Understanding the etiopathogenesis of cognitive impairment is crucial to developing effective treatment. A...
Schizophrenia is increasingly recognized as a systemic disease, characterized by dysregulation in multiple physiological systems (eg, neural, cardiovascular, endocrine). Many of these changes are observed as early as the first psychotic episode, and in people at high risk for the disorder. Expanding the search for biomarkers of schizophrenia beyond...
The human retina and retinal imaging technologies continue to increasingly gain the attention of schizophrenia researchers. With the same embryologic origin as the brain, the retina offers a window into neurovascular changes that may underlie disease. Recently, two technologies that have already revolutionized the field of ophthalmology, optical co...
Citations
... Previous studies have already shown that frailty assessed by Fried's frailty criteria and handgrip strength improve significantly after LVAD and HTx [21]. There is also evidence that cognition, anxiety, and depression improve after LVAD implantation [29,37,38]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/279399741050889-1443625497451_Q64/Mark-Oldham-2.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/280028848902151-1443775489040_Q64/Hochang-Lee-2.jpg)
... Wagner et al. found that schizophrenia was associated with reduced ganglion cell-inner plexiform layer thickness, reduced fractal dimension, reduced vessel density, greater tortuosity, and enlarged cup-to-disc ratio. In contrast to prior literature [59], they did not find an association between schizophrenia and RNFL, comprising the axons of retinal ganglion cells, which propagate to the optic nerve and then project to the brain. As previously mentioned, schizophrenia can affect multiple physiological systems, and when the results were adjusted for hypertension and diabetes, there was no longer an association between schizophrenia and retinovascular characteristics, except using an AI-based fractal dimension estimation, although the ganglion cell-inner plexiform layer thickness and enlarged cup-to-disc associations were retained. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/272169238265879-1441901611526_Q64/Steven-Silverstein.jpg)
... Thinning has been observed in the macula and RNFL [119], ganglion cell layer [120], photoreceptor layer [121], and choroid [122], and evidence from magnetic resonance imaging suggests that retinal changes in schizophrenia are linked to structural changes in the brain and cognitive impairment [123]. Specific layers of the retina have shown both decreased and increased microvascular density (using OCTA) [124], which may help to stratify patients in terms of risk. ...
