Jos P. van Campen's research while affiliated with OLVG and other places

... Therefore, besides spatiotemporal gait measures and the magnitude of variability in these gait measures, dynamic gait measures might potentially provide additional insights in the characterization of gait performance than spatiotemporal measures and their variability only. However, previous research has shown that some of these gait measures are correlated (Hollman, McDade, & Petersen, 2011;Kikkert et al., 2017;Lord et al., 2013;Rehman et al., 2020;Verghese, Wang, Lipton, Holtzer, & Xue, 2007;Wouters et al., 2021), reflecting redundancy. Factor analysis approaches can identify the structure underlying a set of gait measures, which will reduce these redundancies and magnify the unique properties that characterize different aspects of gait performance. ...

... Inappropriate prescribing is common in the elderly and is associated with polypharmacy, and both situations are implicated in adverse health outcomes [1][2][3][4][5]. In addition, patients with advanced age and multimorbidity are at increased risk of being prescribed anticholinergic drugs, which increases the risk of cognitive and functional impairment, falls, hospitalization and death [6][7][8][9]. ...

... Center (WI ADRC) 8 and Wisconsin Registry for Alzheimer's Prevention (WRAP) 9 cohorts (n = 137; 915 CSF proteins quantified), which have been described in detail previously 10 ( Figure 1). The primary replication proteomics data set came from Alzheimer Center Amsterdam related studies, 11 including the Amsterdam Dementia Cohort (ADC), 12 the 90+ Study, 13 and the Twin Study 14,15 (total n = 446). ...

... 1 De onderzoekers brachten bij ruim tweeduizend thuiswonende Turkse, Marokkaanse en Surinaamse patiënten het cognitief functioneren in kaart met de Cross-Culturele Dementiescreening (CCD), een cognitief screeningsinstrument voor dementie bij niet-westerse migranten. 7,8 De prevalentie van dementie en MCI, geoperationaliseerd als een afwijkende score op de CCD, bleek significant hoger te zijn dan bij autochtone Nederlanders. Het onderzoek had beperkingen -de diagnose werd gesteld op basis van een cognitieve screeningstest, een klinische diagnose ontbrak en de resultaten zijn nog niet gereproduceerd in vervolgonderzoek -, maar toch benadrukken de bevindingen het belang van extra aandacht voor deze groep patiënten. ...

... In-home sensors and wearables can detect agitation and monitor activity and sleep patterns [16]. There are a range of indoor localizing technologies for older adults including ambient sensors [21][22][23][24]27], Bluetooth localizers [28][29][30] and combination inertial measurement units with localizer tags [31,32]. ...

... The smoothness of walking, the rhythmic pattern of trunk acceleration, is a dynamic gait metric useful to quantify gait regularity during walking [19][20][21]. Prior works have demonstrated impaired gait smoothness across various populations, such as cognitively impaired individuals, older adults with restricted neuromuscular control, Parkinson's disease patients, and individuals with sensory impairment, compared to young adults and persons without the disease [21][22][23][24][25][26][27]. According to recent studies, trunk accelerations are more sensitive than traditional spatiotemporal metrics for capturing subtle alterations in gait [26,28]. ...

... Disproportionate accumulation of lipedema tissue on the inner leg causes valgus stresses (increasing the risk of meniscus damage and osteoarthritis), 5 restricts knee flexion, 6 and alters gait mechanics, which is a risk factor for falls. 7 Lipedema tissue can grow and present in three stages: stage 1 is thickening and disproportionate accumulation of SAT in the extremities with smooth skin; stage 2 is increased fibrous SAT with skin indentations; stage 3 lipedema tissue forms lobules of skin and SAT. Women with stage 2-3 lipedema often have swelling on physical examination and most have evidence of impaired lymphatic function (Fig. 1). ...

... Применение потенциально неэффективных лекарственных препаратов и полипрагмазия ассоциированы с синдромом СА, наличие которой, в свою очередь, влияет на приверженность лечению и ответ на терапию [10,11]. Так, например, нарушение походки в большей степени ассоциировано с СА, чем с приёмом психотропных препаратов [12]. Наоборот, в настоящее время не найдено убедительных дынных о влиянии СА на эффективность антигипертензивной терапии у пациентов 80 лет и старше [13]. ...

... Gait requires integrity of both musculoskeletal and central nervous systems, and its measurement appears to be a useful proxy for health and physical function [8,9]. Importantly, a decline in gait speed is associated with the development of dementia in older adults [10][11][12][13][14][15]. Additionally, spatiotemporal gait characteristics, reflecting different domains of gait including pace (stride and step lengths), rhythm (swing, step, stance, and stride times), and variability (standard deviations of step/stride length and time), are associated with both cognitive decline and dementia [16]. ...

... The number of people living with dementia is expected to increase in the coming years. People with an immigration background are at an increased risk of developing dementia and are more likely to experience barriers in accessing dementia services and care, which may lead to health inequities and a reduction of quality of life [5][6][7]. Hence, there is a need to develop and coordinate dementia care plans, including the use of technology, for marginalized older adults living with dementia, such as those with an immigration background and low literacy levels [8]. ...