Jorma Jalonen's research while affiliated with University of Oulu and other places

... The selection of different probe drugs for in vitro and in vivo evaluation of CYP enzyme activity was based on the recommendations given by United States Food and Drug Administration (USFDA) regulatory authority and the literature preference [22,27,34,[37][38][39][40]. Previous reports have demonstrated the selection criteria of probe substrates for CYPs which includes the availability of substrate and metabolite standards, selectivity, sensitivity, sufficient metabolite production at low substrate concentrations, effect of organic solvents, intersubstrate interactions, metabolic and kinetic properties, etc. [41,42]. In each case, the substrate is metabolized exclusively or primarily by its specific enzyme. ...

... The results revealed that shoot cultures exhibited higher efficiency in terms of biomass and hypericin production, regardless of flask or bioreactor scale. Additionally, bioreactors outperformed flask-scale production in terms of hypericin, pseudohypericin, and hyperforin yields using shoot cultures (Karppinen et al. 2004). The impact of carbon Transgenic plants of Nicotiana tabacum and Lactuca sativa overexpressing Hyp-1 showed decreased efficiency in Agrobacterium-mediated expression. ...

... Hence, for a long time mainly other non-European Drosera species have been used for pharmaceutical purposes [8], namely D. madagascariensis oe. and D. pe/tata Sm. [9,10]. While for D. rotundifo/ia NO levels between 1.0 and 2.3 % have been reported [11][12][13][14], much lower amounts of max. 0.063 % were detected in various sampies of D. madagascariensis by Krenn et al. [9,10] . ...

... The example of such constituents is hypericins, stored in secretory glands present in leaves, stems, and petals of Hypericum perforatum and related species [20]. Since the nonorganized cultures of the above plants yielded only low amounts of naphthodianthrones, bioreactor-grown Hypericum shoots were evaluated as their alternative source [20,[49][50][51]. Another example is artemisinine, a sesquiterpene lactone being the essential drug in malaria treatment. ...

... 62 The former investigations reported that M. piperita oil composition are found menthol and menthone as major compounds. [63][64][65][66][67][68][69][70] The diversity in antioxidant capacities with the reported that one may be attributed to different procedures followed or a different geographical environment, plant type, seasonality, physiological age of the plant, and the method of oil isolation. 40 The antioxidant capacity of mints greatly depends on the presence of phenolics compounds. ...

... For comprehensive and rapid screening, ordinary single substrate assays are cumbersome and slow. The N-in-one approach allows nine major CYP enzymes (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4) to be simultaneously monitored using ten probe reactions (Turpeinen et al., 2005; Tolonen et al., 2007). The aim of this work was to investigate the potential inhibitory interactions of a selection of widely used pesticides belonging to different chemical groups by the N-in-one assay and to 0887-2333/$ -see front matter Ó 2012 Elsevier Ltd. ...

... No caso da ocorrência de um passivo ambiental como o derramamento de combustíveis em sistemas de águas superficiais e subterrâneas, há uma necessidade cada vez maior de reabilitação dessas áreas, tanto para as populações locais quanto para a indústria (Chiu et al., 2017;Saari, 2009). Apesar disso, os acidentes com derramamento não são a única fonte desse tipo de contaminação. ...

... According to the Food and Agricultural Organization (FAO)/World Health Organization (WHO), acceptable cyanide level in edible plants is 10 mg HCN/kg dry weight. [32] Over the past few years, several methods of extraction for genus Rhodiola have been proposed to obtain the best extraction efficiency, considering most of all: water, [14,17,19,[33][34][35][36][37][38] ethanol, [10,18,19,25,34,37,[39][40][41][42][43][44][45][46][47][48] methanol [9,16,23,[49][50][51][52][53][54][55][56][57][58] and also acetone [59] and ethylacetate [19] as solvents. ...

... The smell may cause headaches to some people. The chemical compositions of the essential oils (EOs) of the entire plant or separated aerial parts (mostly shoots) of Rh. tomentosum have been studied in some European countries [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19], the Far East and Siberia [20][21][22][23][24][25], and Asian countries [17,[26][27][28][29][30][31][32][33][34][35][36][37]. A lot research works have been focused on the evaluation of bioactivities of marsh rosemary extracts. ...

... Hydrolysis is more often than not involved in metal-oxo cluster formation, especially in water environment [78,138,178]. It requires a water molecule to form an oxo-cluster precursor from the dissolving metal-bearing compound [86]. ...