John Mikszta's scientific contributions

Publication (1)

Chapter
Conventional drug delivery using pills or injection is often not suitable for new protein, DNA, and other therapies.¹⁻³ An attractive alternative involves transdermal delivery from a patch, which avoids (i) degradation in the gastrointestinal tract and first-pass effects of the liver associated with oral delivery and (ii) the pain and inconvenience...

Citations

... They consist of micron-sized projections that pierce the stratum corneum allowing the drugs to bypass the main barrier to diffusion. Studies have shown that the microneedle arrays cause no or little pain and are well tolerated by users, making it preferential to injection by syringe (Simonsen et al. 1999;Nir et al. 2003;Prausnitz et al. 2005). The microneedles can also offer a number of other benefits over other drug delivery methods. ...