John MacDonald's scientific contributions
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It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
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Publication (1)
Recent events have made it apparent that the creatinine based estimating equations for glomerular filtration have their flaws. Some flaws have been known for some time; others have prompted radical modification of the equations themselves. These issues persist in part owing to the behaviour of the creatinine molecule itself, particularly in acute a...
Citations
... 9 Serum CysC allows the calculation of estimated GFR (eGFR) and has been considered to be more accurate than serum creatinine determinations. 26,[31][32][33][34] Serum creatinine is subject to individual variation and is an unreliable marker for estimating renal function in pediatrics due to dependence on muscle mass and age 35,36 Especially in CblC deficiency, borderline reduced serum creatinine concentrations have been observed. 37 Normalization of biomarker concentrations to urinary creatinine levels is a common practice, but it should be noted that in CKD and in disorders of creatinine metabolism, such as in CblC deficiency, may lead to lower urinary creatinine levels. ...
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