Johannes Järhult's research while affiliated with Länssjukhuset Ryhov and other places

... [71] It should also be taken into account that lithium-related HPT may develop with lithium treatment for 10 years or longer. [72,73] It should not be forgotten that excessive Vitamin D intake, excess Vitamin A, estrogen therapy, antiestrogen therapy or androgens, aminophylline or theophylline, ganciclovir, recombinant growth hormone therapy in patients with AIDS may cause hypercalcemia. [64] Physiological secondary HPT may occur in cases such as stage 3-5 chronic kidney disease, vit D deficiency, Ca malabsorption, renal hypercalciuria, bisphosphonate, and denosumab use to compensate for calcium intake deficiency. ...

... Thyroid (Kibirige et al., 2013) and parathyroid (Meehan et al., 2018) abnormalities affect up to 25% of patients receiving lithium treatment. Lithium is highly concentrated in the thyroid glands and inhibits iodine uptake, iodothyrosine coupling, thyroxine secretion, and modifies thyroglobulin structure (Pérez-Castro et al., 2021). ...

... Several studies have shown that the incidence of postoperative hypocalcemia after PHPT ranges from 4.1% to 21.3% (7)(8)(9), which shows that patients are at high risk of postoperative hypocalcemia. In order to effectively prevent and timely respond to the occurrence of postoperative hypocalcemia in PHPT patients, several research institutions have conducted research and concluded that the age, the preoperative alkaline phosphatase levels, and the preoperative blood calcium levels are related to postoperative hypocalcemia (10)(11)(12). With the introduction of routine serum calcium monitoring in several countries around the world, fewer patients with clinically significant primary hyperparathyroidism and moderate to severe preoperative serum calcium levels have been identified. ...

... Lithium, through GSK-3 inhibition, contributes to irregular Wnt/b-catenin signalling, believed to be significant for the development of parathyroid adenomas and hyperplasia [31]. Theoretically, lithium should exert an equal effect on all parathyroid glands [32]. Carchman et al. [9], however, state that there is no significantly increased risk for multiglandular disease (MGD) in lithium-treated patients. ...

... It was found that 5 of 31 patients whose PTH levels were within the reference range before follow-up developed hyperparathyroidism after follow-up 28 . In another study, 18 % of 423 patients in whom the prevalence of lithium-related hyperparathyroidism was attempted to be determined had lithium-related hyperparathyroidism, and 43 % had vitamin D insufficiency 29 . It is known that vitamin D deficiency can cause elevations in PTH levels 30 . ...

... Proponents of the conservative approach in asymptomatic RSG have quoted the lack of strong evidence and the high complication rate associated with surgery as their argument. [13][14][15][16] On the other hand, proponents of surgery cite the natural history of progressive growth, absence of alternative treatment, low complication rates in experienced hands, and risk of hidden malignancy as their argument. [17][18][19][20] The purpose of this study was to compare the outcomes and complications of performing thyroidectomy for patients with symptomatic and asymptomatic RSGs and present a management algorithm based on patients' medical risk profiles. ...

... We also did not refer to the potential impact of IONM on surgeon's performance and his or her level of experience during thyroidectomy (67), reported disadvantages (68) and important advancements of this technology (18). Another weak point is that we have completely detached the identification technique and handling of the RLN from the extent of thyroidectomy (69) and from conditions that render the nerve vulnerable to injury, such as the presence of RLN extra-laryngeal branching (70), the use of energy devices (71) and inappropriate traction on the thyroid lobe (72). All these aspects should be also considered for a typology in terms of RLN management during thyroid surgery. ...

... This level of agreement seems to depend more on the degree of closeness and relationship in everyday life than the professional nature or family relationship [28,29]. On the other hand, caring is also associated with a burden and can be stressful and can have an effect on the caregiver's own QoL [32,33], which can, in turn, influence the perception of the individual with IDD. Our study is in agreement with other studies, in other contexts/populations, where the answers of family members/caregiver/reference technician tend to underestimate the QoL scores, which may be associated with a less concrete and visible perception of certain domains of QoL, or that the level of agreement decreases as the disability/illness becomes more severe [34][35][36][37]. ...

... [42][43][44] Pleiotropic functions of CART are also known in endocrine cells. [45][46][47][48] To better pinpoint the role of CART in the proliferation and remodeling of the biliary epithelium, we performed in vitro studies in control rat cholangiocytes and we further demonstrated that the effects of CART on the proliferation of biliary epithelium are mediated by enhanced cholangiocyte BDNF secretion. NTs, a family of dimeric proteins working as growth factors, include NGF, NT-3, NT-4, BDNF. ...

... La malattia sottostante e l'entità della resezione hanno una chiara influenza sul rischio di sviluppare ipoparatiroidismo dopo l'intervento. La linfoadenectomia, in particolare, aumenta il rischio di devascolarizzazione perché l'arteria tiroidea inferiore è spesso legata prossimalmente alla sua origine [14][15][16]. ...