Jingjing Li's research while affiliated with University of Texas MD Anderson Cancer Center and other places
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Publications (4)
Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer (NK) cells. IFN-α/β produced by pDC...
The mechanism by which plasmacytoid dendritic cells (pDCs) promote humoral autoimmunity is unclear. In amyloid-induced experimental autoimmune model, pDC activation is accompanied by prominent neutrophilia. We investigated the contribution of neutrophils since neutrophils have been critically implicated in the pathogenesis of systemic autoimmunity....
Proteins carry out crucial tasks in organisms by exerting functions elicited from their specific three dimensional folds. Although the native structures of polypeptides fulfill many purposes, it is now recognized that most proteins can adopt an alternative assembly of beta-sheet rich amyloid. Insoluble amyloid fibrils are initially associated with...
Citations
... IFN-γ and TNF-α released by neutrophils delay myogenesis [59]. Neutrophils generate reactive oxygen species (ROS), which breaks down damaged muscle tissue and also regulates humoral autoimmunity via inhibition of IFN-γ [60,61]. TNF-α and IL-1β also enhance IFN-γ receptor expression and augment neutrophil recruitment [62]. ...
... Amino acid sequence analyses gradually led to the discovery that each type of amyloid consists of a different fibril protein and, in the 2000s, the term "amylome" was introduced to describe the multitude of proteins potentially able to generate amyloid-like fibrils, many of which, however, do so only under certain in vitro conditions. It is therefore mandatory to clarify exactly what we mean by the term amyloid (11,12). ...