Jin-Hao Zhu's research while affiliated with Nanjing University of Chinese Medicine and other places
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Publications (16)
Glutathione (GSH) is an important antioxidant that is generated and degraded via the GSH cycle. Quantification of the main components in the GSH cycle is necessary to evaluate the process of GSH. In this study, a robust ultra‐performance liquid chromatography‐tandem mass spectrometry method for the simultaneous quantification of 10 components (GSH;...
Ethnopharmacological relevance:
Rehmanniae Radix Praeparata (RRP), the processed root of Rehmannia glutinosa, has been widely used to treat Yin deficiency syndrome in traditional Chinese medicine. RRP is available in two forms: processed by steaming with water (SRR) or processed by stewing with yellow rice wine (WRR). Previous work has documented...
Si-Jun-Zi decoction (SJZD) with ginseng as the principal medicinal herb is a traditional Chinese Medicine multi-herb prescription that commonly employed to treat colorectal cancer etc. Previous studies showed that nearly half of the commercial ginseng was sulfur-fumigated, one of the postharvest processing methods that commonly causes sulfur-dioxid...
Ethnopharmacological relevance
Chang-Kang-Fang (CKF) is a traditional Chinese herbal formula used for treatment of irritable bowel syndrome (IBS) in China. Decoction is the administration form of CKF in clinical practice. Previously, CKF has been confirmed with activities of releasing pain and reversing disorders of intestinal propulsion. And alkal...
Aliphatic aldehydes are toxic substances that correlate with the onset of many diseases. However, up to date, the methods to identify aliphatic aldehydes in biological samples are less selectivity and/or robustness. In this study, a strategy based on 2,4-dinitrophenylhydrazine (DNPH) capturing combined with mass defect filtering (MDF) was establish...
Our previous study found that Qiong-Yu-Gao (QYG), a traditional Chinese medicine formula derived from Rehmanniae Radix, Poria, and Ginseng Radix, has protective effects against cisplatin-induced acute kidney injury (AKI), but the underlying mechanisms remain unknown. In the present study, the potential role of gut microbiota in the nephroprotective...
Short-chain fatty acids (SCFAs) play key roles in maintaining health and treating disease. Quantification of important fecal SCFAs is necessary to facilitate the clarification of their biological roles. However, the existing quantifying methods mainly depend on complicated precolumn derivatization, and/or are unable to determine formic acid, a SCFA...
Ethnopharmacological relevance
Sulfur-fumigation undoubtedly alters the chemical and metabolic profiles, but controversially affects the efficacy and safety of medicinal herbs.
Aim of the study
To comprehensively evaluate the effects of sulfur-fumigation on the efficacy and safety of medicinal herbs using a meta-analysis approach and further inves...
In present study, a comprehensive strategy integrating multiple chromatographic and chemometric methods to simultaneously characterize the volatile and non-volatile components was developed for the holistic quality evaluation of commercial Agastache rugosa (AR), a common edible and medicinal herb, collected in China. The volatile components and the...
Background
Transcatheter arterial chemoembolization (TACE) is a standard therapy to treat hepatocellular carcinoma (HCC), but often limited for its complications. Ginsenosides, including total ginsenosides (GS), Rg3, Rh2 and CK, have been clinically used as adjuvants of TACE in HCC therapy. However, partial clinical observations concerning the effi...
Ginseng and its ingredients benefit the curative effects and alleviate the adverse reactions of chemotherapy during non-small cell lung cancer treatment.
Cicadae Periostracum (CP), the cast-off shell of Cryptotympana atrata, is specified in Chinese Pharmacopoeia for relieving fever and eliminating ulcer. N-acetyldopamine oligomers are the major characteristic bioactive components with antioxidant and anti-inflammatory activities that may be responsible for the efficacy of CP. However, the exposed co...
Background and objective:
Ginseng is usually consumed as a dietary supplement for health care in the normal state or prescribed as a herbal medicine in pathologic conditions. Although metabolic studies of ginseng are commonly performed on healthy organisms, the metabolic characteristics in pathologic organisms remain unexplored. This study aimed t...
Citations
... Radix Rehmanniae (RR) is the root of R. glutinosa [2], which is classified into the top grade by Shennong's Classic of Materia Medica. RR is employed in a variety of famous traditional Chinese medicine (TCM) prescriptions, such as Liuwei Dihuang Pill, Zhibai Dihuang Pill, Qiju Dihuang Pill, and Dihuang Yinzi, owing to its ability to nourish Yin and tonify the kidney [3,4]. There are three processing forms frequently used in clinic, including fresh Radix Rehmanniae (FRR), raw Radix Rehmanniae (RRR), and processed Radix Rehmanniae (PRR), with their pharmacological actions varying greatly from heatclearing to tonification [5]. ...
... Previous studies have proved that Rg1, one of the most abundant dammarane type ginsenosides, transformed to 24-sulfo-25-ene ginsenoside Rg1 (25-ene SRg1) and 24-sulfo-25-hydroxy ginsenoside Rg1 (25-OH SRg1) during sulfur-fumigation (Zhang et al., 2018), but with unclear generation mechanism. Of which, 25-ene SRg1 is one of the most abundance sulfur-containing ginsenosides, which is stably existed in sulfur-fumigated ginseng and its preparations (Liu, Wang, Zhu, Xu, et al., 2022;Zhang et al., 2018). Therefore, 25-ene SRg1 is a potential marker to identify sulfur-fumigated ginseng and its preparations. ...
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... Zou (SCFA-producing bacteria) and its metabolites (acetic acid, butyric acid). 104 Moreover, a potent acetic acid-producing bacterium, Desulfovibrio vulgaris, was identified as a potential biomarker for NAFLD remission based on co-housing experiment combined with bacterial screening by Hong et al. 23 ...
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... Herbal medicines, derived from natural sources, have been utilized to prevent and treat various diseases and ailments for thousands of years (Jouyandeh et al., 2022;Liu et al., 2022). According to the World Health Organization (WHO), the demand and consumption of herbal medicine are on rise in both developed and developing countries (Liu et al., 2022;Yang et al., 2020;Zhu et al., 2021b). ...
... As it is known, among a wide range of exogenous antioxidants, polyphenols are one of the most effective classes of compounds possessing antioxidant properties. Numerous data of scientific literature regarding the polyphenolic profiles of the different Lamiaceae species demonstrated that rosmarinic acid is quite often their common major compound 14,[23][24][25][26][27][28][29][30] . Thus, the ultra-performance liquid chromatography analysis of methanolic extracts from A. rugosa roots revealed the predominance of rosmarinic acid among 24 identified polyphenols 25 . ...
... Herbal medicines, derived from natural sources, have been utilized to prevent and treat various diseases and ailments for thousands of years (Jouyandeh et al., 2022;Liu et al., 2022). According to the World Health Organization (WHO), the demand and consumption of herbal medicine are on rise in both developed and developing countries (Liu et al., 2022;Yang et al., 2020;Zhu et al., 2021b). Meanwhile, with the huge consumption of herbal medicines, great amounts of herbal medicinal residues (HMRs), the by-products of herbal medicine after decocting with water or ethanol, were produced (Wang et al., 2021;Zhu et al., 2021a). ...
... According to the World Health Organization (WHO), the demand and consumption of herbal medicine are on rise in both developed and developing countries (Liu et al., 2022;Yang et al., 2020;Zhu et al., 2021b). Meanwhile, with the huge consumption of herbal medicines, great amounts of herbal medicinal residues (HMRs), the by-products of herbal medicine after decocting with water or ethanol, were produced (Wang et al., 2021;Zhu et al., 2021a). In China alone, the production of HMRs is as high as 60-70 million tons in the year of 2015, and which is still keeping increase (Meng et al., 2017;Zhou et al., 2018). ...
... It has been reported that the extracts of CP have several bioactivities, including anti-oxidant, anti-inflammatory, spasmolytic, and anti-asthma, etc. [8][9][10]. Our previous studies found that N-acetyldopamine oligomers were the main components that might be responsible for the activities of CP [11,12]. Moreover, amino acids have been reported as another type of bioactive component of CP [13]. ...
... After the oral administration of ginsenoside Rg3 in walker 256 tumorbearing rats, the areas under the plasma level/time curve (AUC) of Rg3 and Rh2 both decreased, which indicated that the transformation of Rg3 into Rh2 might also be inhibited [36]. Interestingly, even though immunosuppression can always be found in tumor environment, ginsenosides F2, Rg3, Rd, Rh1, Rg1 and CK were found to be more abundant in immunosuppressed rats [37]. Moreover, the mental disease can also affect the oral bioavailability of ginsenosides. ...
