Jie Ren's research while affiliated with Shanghai Normal University and other places
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Publications (5)
Cancer is a common malignant disease worldwide with an increasing mortality in recent years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the treatment of cardiovascular and cerebrovascular diseases for thousands of years. The liposoluble tanshinones in S. miltiorrhiza are important bioactive components and main...
Bioactive chemical constitutes from the root of Salvia miltiorrhiza classified in two major groups, viz., liposoluble tanshinones and water-soluble phenolics. Tanshinone IIA is a major lipid-soluble compound having promising health benefits. The in vivo and in vitro studies showed that the tanshinone IIA and salvianolate have a wide range of cardio...
Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of cardiovascular diseases. WRKYs play important roles in plant metabolism, but their regulation mechanism in Salvia miltiorrhiza remains elusive. In this study, one WRKY transcription factor SmWRKY1 was isolated and functionally characterized from S. miltiorrhiza. Mu...
Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of cardiovascular diseases. WRKYs play important roles in plant metabolism, but their regulation mechanism in S. miltiorrhiza remains elusive. In this study, one WRKY transcription factor SmWRKY1 was isolated and characterized from S. miltiorrhiza. Multiple sequence a...
Citations
... Tan, the main lipophilic constituents extracted from the roots and rhizomes of SM, have been reported to possess several biological functions, including anti-inflammatory, anticoagulant, anticancer, and antibacterial properties. 23 In recent years, studies have focused on identifying Tan as apoptosis-inducing compounds for cancer cells. For example, Tan IIA has been found to inhibit colorectal cancer cell growth by activating the ROS/JNK signaling pathway, leading to cell autophagy and apoptosis. ...
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... Danshen, or S. miltiorrhiza, is a TCM known for its prominent cardiovascular benefits [28]. One of its main pharmaceutical effects is attributed to its ability to promote blood circulation and alleviate conditions related to cardiovascular health [29]. The main active compounds in Danshen include tanshinones and salvianolic acids, which exhibit antioxidant, anti-inflammatory, and vasodilatory properties [30]. ...
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... Subsequently, based on the published genomic data, we cloned and analyzed the cis-elements in the promoter regions of JAs and tanshinone biosynthetic genes [32,33] . As shown in binding sites for the above-mentioned transcription factors. ...
