Jianxin Du's research while affiliated with Shandong University and other places
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Publications (6)
C-reactive protein (CRP) acts as a biomarker reflecting different degrees of inflammation. Accumulating reports have suggested that there is a close relationship between CRP and various cancers. However, the influence of CRP on the development of tongue squamous cell carcinoma (TSCC) remains unclear. The purpose of this study was to investigate the...
The differentiation of mesenchymal cells in tooth germ and dental pulp cells into odontoblasts is crucial for dentin formation, and the transcription factor runt-related transcription factor (Runx2) is necessary for odontoblast differentiation. Our previous study demonstrated that four and a half LIM domains 2 (FHL2) may play an important role in t...
Introduction: Tooth-related factors, such as cemento-enamel projections and furcations, are contributing factors to periodontal disease. Tooth morphologic variations in the anterior teeth are less frequently reported.
Case Presentation: A 25-year-old female patient was referred to our clinic with generalized severe aggressive periodontitis. An acce...
Nel-like molecule-1 (Nell-1) is a recently discovered secreted protein that plays an important role in osteoblast differentiation, bone formation, and bone regeneration. However, its expression and distribution during tooth development are largely unknown. The aim of this study was to investigate the expression patterns of Nell-1 during murine mola...
Four and a half LIM domains 2 (FHL2) functions as a transcriptional co-activator or co-repressor in a cell-type-specific manner. As a positive regulator, FHL2 plays an important role in osteoblast differentiation and bone formation. Our previous study showed that FHL2 was expressed in odontoblasts in mature human teeth under normal and pathological...
Citations
... In addition, the high expression of IL-6 and CRP may indicate changes in the cancer immune microenvironment. Several studies have reported that poorly differentiated cancers show higher tissue CRP expression and higher serum CRP levels [27,28]. Moreover, mesenchymal-like tumor cells and stromal cells common to the tumor microenvironment have also been shown to secrete cytokines, including IL-6, which is involved in the synthesis of CRP as well as its secretion [29] and significantly enhances the success of tumor growth and metastatic implantation in vivo [30,31]. ...
... Thus, effective strategies are needed to repair and regenerate injured dental pulp. A lot of studies have demonstrated that the use of growth factors onto the injured pulp may reduce inflammatory cell responses and accelerate pulp regeneration (Du et al. 2016;Nakashima and Reddi 2003;Yoshida et al. 2016;Zhang et al. 2019). The application of growth factors can avoid the risk of pulpal necrosis which may be induced by the irritation of calcium hydroxide (Hu et al. 1998). ...
... [3] Accessory root form, usually seen in mandibular canine, premolar and molar teeth, is a rare anomaly in maxillary lateral incisors. [4][5][6] It has been reported that accessory root formation may occur as a result of traumatic injury of the Hertwig's epithelial root sheath during the root development or changes in the functions of odontoblasts. [7] Case Report A 65-year-old male patient who has type II diabetes and hypertension applied to Ondokuz Mayıs University, Faculty of Dentistry, Department of Periodontology with complaints of inflammation and mobility in the upper right central incisor tooth. ...
... Nell-1 has been reported to be a critical secretory protein in bone remodeling and osteoblastic cell differentiation and proliferation, as well as tooth development [61]. Numerous studies in animal models have shown the osteo-inductive activity of Nell-1 in accelerating bone regeneration [62,63]. ...
... In this system, the effect of FHL2 varies depending on the presence of distinct partner proteins (see Tran, Kurakula, Koenis, & de Vries, 2016). During vertebrate embryonic development, dynamic expression domains of Fhl2 have been observed in the teeth, cardiac and skeletal muscles, and larger blood vessels (Chu, Ruiz-Lozano, Zhou, Cai, & Chen, 2000;Du, Wang, Wang, Wang, & Yang, 2012;Martin et al., 2002;Rafael et al., 2012;Tran et al., 2016). However, their functional significance remains obscure, as Fhl2-deficient mice are morphologically normal at birth (Chu, Bardwell, et al., 2000). ...
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