Jianqiang Zhu's research while affiliated with Tianjin Medical University Cancer Institute and Hospital and other places
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Publications (20)
Purpose
Establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2) is involved in the mitotic S-phase adhesins acetylation and is responsible for bridging two sister chromatids. However, present ESCO2 cancer research is limited to a few cancers. No systematic pan-cancer analysis has been conducted to investigate its role in diagnosis,...
Background
Prostate cancer (PCa) has a high incidence in men worldwide, and almost all PCa patients progress to the androgen-independent stage which lacks effective treatment measures. PTENP1, a long non-coding RNA, has been shown to suppress tumor growth through the rescuing of PTEN expression via a competitive endogenous RNA (ceRNA) mechanism. Ho...
Stem cell (SC) therapy has been shown high prospects in erectile dysfunction (ED) treatment. Without ethical issues and risks of immune rejection and tumorigenesis of exogenous SC therapy, endogenous stem/progenitor cells (S/PCs) have a better potential for ED management, and their homing and redistribution are controlled by SDF1-α/CXCR4 axis. Cons...
Along with the increasing production and application of graphene oxide (GO), its environmental health and safety (EHS) risks have become a global concern. Numerous studies have investigated the biosafety and toxicity mechanisms associated with GO, however, the majority of previous studies were based on its direct toxic dose, which could not reflect...
Background
The primary cilia (PC) is a microtubule-based and nonmotile organelle which protrudes from the surface of almost all mammalian cells. At present, PC has been found to be a deficiency or loss in multiple cancers. Restoring PC could be a novel targeting therapy strategy. Our research showed that PC was reduced in human bladder cancer (BLCA...
Purpose: Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2 (ESCO2) is a member of histone acetyltransferases. ESCO2 is involved in the mitotic S-phase adhesins acetylation and is responsible for bridging two sister chromatids. However, present ESCO2 cancer research is limited to a few cancers. No systematic pan-cancer analysis has be...
Objective
To evaluate the comprehensive complication index(CCI) and Clavien‐Dindo classification(CDC) for short‐term postoperative complications in radical cystectomy and assess cumulative surgical morbidity to compare sufficient surgical skill.
Methods
From September 30, 2010, to October 1, 2020, clinical data of patients with urothelial carcinom...
Peripheral nerve injury (PNI) is a relatively common disease caused by various circumstances, ultimately affecting the life quality of patients. Although existing medications and surgical interventions have particular benefits for nerve repair, more effective therapeutic strategies are urgently needed for various types of nerve injuries. Increasing...
Graphene oxide (GO) has been widely studied and applied in numerous industrial fields and biomedical fields for its excellent physical and chemical properties. Along with the production and applications of GO persist increasing, the environmental health and safety risk (EHS) of GO has been widely studied. However, previous studies almost focused on...
SCL/TAL1 Interrupting locus (STIL) is a ciliary-related gene involved in regulating the cell cycle and duplication of centrioles in dividing cells. STIL has been found disordered in multiple cancers and driven carcinogenesis. However, the molecular mechanisms and biological functions of STIL in cancers remain ambiguous. Here, we systematically anal...
Fluorescence is routinely used for in vivo tracking and imaging of molecules and nanostructures with assuming that the fluorescence intensity is proportional to the dye concentration. Herein, we report the unique tumor-specific fluorescence character of rhodamine B isothiocyanate derivatives (RBITCs), which emits fluorescence selectively in cancero...
With the development of human society, haze has become an important form of air pollution. Haze is a mixture of fog and haze, and the main component of haze is fine particulate matter (PM2.5), which is the most important indicator of composite air pollution. Epidemiological studies proved that PM2.5 can break through the respiratory mucosal barrier...
Nanomedicines are being developed to treat diverse diseases; however, inadvertent or unintended health effects has to be considered, especially for those targeting cancers. For cancers, occurrence of metastasis hints an advanced phase of cancer progression, nanomedicines per se should be evaluated for their effects on existing metastatic tumors and...
Owing to the novel physicochemical properties of graphene, materials such as graphene oxide (GO) are being developed for applications in various fields such as biomedicine. Nonetheless, considerable knowledge gaps still exist regarding the impact of GOs on environmental health and safety (EHS). Thus far, its secondary toxicity, synergistic effects,...
The unique physicochemical properties of two dimensional (2D) graphene oxide (GO) could greatly benefit the biomedical field; however, recent research demonstrated that GO could induce in vitro and in vivo toxicity. We determined the mechanism of GO induced toxicity, and our in vitro experiments revealed that pristine GO could impair cell membrane...
Citations
... The Kaplan-Meier Plotter database comprise an evaluation of the impact of 54,675 genes on survival outcomes in 21 cancers and many studies have used Kaplan-Meier Plotter database to assess the correlation between genes and cancer prognosis [37,38]. What's more, previous studies have reported the relationship between STIL and prognosis of cancers using the Kaplan-Meier Plotter database [39]. Therefore, we used the Kaplan-Meier Plotter database for analysis and found that high STIL expression is correlated with poor prognosis of breast cancer. ...
... Electrical conductivity was evaluated as EC (%) = S1/S2 [30]. Biochemical index determination kits (Abbkine Scientific Co., Ltd., Wuhan, China) were used for the determination of superoxide dismutase activity (SOD), catalase activity (CAT), glutathione s-transferase activity (GST), α-amylase activity, malondialdehyde content (MDA), proline content (Pro), soluble protein content, and soluble sugar content [31]. ...
... In our previous study, STIL is upregulated in tumor tissues and is closely related to the bad prognosis of patients. STIL could regulate PC and affect the cell cycle of kidney and prostate cancer cells [16]. This study found that STIL expression was up-regulated in bladder cancer tissues and cell lines. ...
... IL-6/IL-6R inhibition may be an effective strategy to inhibit tumor progression and metastasis [142][143][144]. Palladium nanoplate-based IL-6R antagonists have been designed to deliver tocilizumab to the liver for hepcidin suppression, which alleviates cancer-associated anemia and simultaneously inhibits tumor progression, partly due to corrected anemia, in murine models [145]. Higher IL-6 levels and a greater number of T helper 17 (Th17) cells were observed in ICI-induced immune-related enterocolitis, and IL-6 inhibition increased the ICIinduced anti-tumor efficacy [146]. ...
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... Breast tumors expressing low levels of TRDMT1 are more responsive to radiotherapy. Du et al. [20] analyzed the clinical relevance of m5C regulators in pan-cancer. Liu et al. [21] wrote that the RNA m5C modifcation and its regulators have been shown to be involved in the progression of various cancers, including hepatocellular carcinoma, bladder cancer, glioblastoma multiforme, breast cancer, and head and neck carcinoma, indicating that RNA m5C might play an important role in tumorigenesis and progression. ...
... Based on the functional moieties of GSH-responsive delivery systems, they can be categorized into five main groups: disulfide, diselenide/ditelluride, thioether/selenide/tellurium, metal-thiol-based linkers, and ferrocenium. These moieties, along with their mechanisms and applications, have been summarized in Table 2. [63][64][65][66][67][68][69][70][71][72][73][74][75] In this review, we will delve into the specifics of each of these moieties to gain a better understanding of their potential in GSH-responsive delivery systems. ...
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... For instance, increased concentrations of cortisol, a hormone associated with stress, can decrease the flow of blood to the placenta and hinder the transfer of nutrients, therefore affecting the growth of the fetus [77]. Disturbances in estrogen and progesterone signaling can impact the formation of the placenta and its capacity to sustain the fetus [78]. Furthermore, modified insulin signaling can influence the metabolic processes and development of the fetus. ...
... However, according to a different study, GO might promote the movement and spread of cancerous cells. Low-dose GO has been shown to boost transforming growth factor-beta (TGF-β) synthesis, which in turn causes an increase in metastasis and the epithelial-to-mesenchymal transition (EMT) [28]. Graphene oxide nanoparticles can interact with the membranes of cancer cells, causing the cells to internalize the particles into their cytoplasm [29]. ...
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... When 80-90% confluence was reached, cells were separately treated with s-GOs and l-GOs at 0.1, 1, 10, 50, 100, and 250 µg/mL for 6 h and 24 h. The dose of 0.1~250 µg/mL was selected based on previous studies that reported that the IC50 value of GO cytotoxicity is approximately within the range from 50 to 100 µg/mL [41,42]. The relative cell viability was calculated as the percentage of untreated cells. ...
... They associated this with changes in the organization of actin filaments after treatment. Zhu et al. [60] reported that the permeability of the membranes of cancer cells increased after treatment with GO, making them more suitable for drug delivery. In our study, the decrease in stiffness of cells treated with the MTX/GO complex compared to the control group and groups treated with MTX alone may be associated with altered membrane permeability, particularly due to GO. ...
