Jianfei Li's research while affiliated with Yunnan Normal University and other places
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Publications 0
Although studies have demonstrated that genome instability is accumulated in patients with Alzheimer's disease (AD), the specific types of genome instability linked to AD pathogenesis remain poorly understood. Here, we report the first characterization of the age‐ and sex‐related trajectories of telomere length (TL) and micronuclei in APP/PS1 mice...
Obese subjects have a high baseline of genotoxic stress, but the underlying mechanism is poorly understood. Given that obesity is associated with high bile acids (BA) and low folate, we aimed to determine the interactive effect of folate deficient or supplementation to the genotoxicity and cytotoxicity of BA in human colon and liver cells. NCM460 a...
Elevated Homocysteine (Hcy) is associated with increased risk of vascular disease, but whether it induces genotoxicity to vascular endothelial cells remains unknown. Here, we conducted a comprehensive study of the genotoxicity, and unexpected anti-genotoxicity, of Hcy by cytokinesis-blocked micronucleus assay in HUVECs and erythrocyte micronucleus...
As human life expectancy increases substantially and aging is the primary risk factor for most chronic diseases, there is an urgent need for advancing the development of post-genomic era biomarkers that can be used for disease prediction and early detection (DPED). Mosaic loss of Y chromosome (LOY) is the state of nullisomy Y in sub-groups of somat...
Glutamine (Gln) is a non-essential amino acid central for generating building blocks and cellular energy in tumours and rapidly proliferating non-transformed cells. However, the influence of Gln on regulating chromosomal stability of transformed and non-transformed cells remain poorly understand. We hypothesised that Gln is required for maintaining...
Citations
... It has been known that the TL of buccal mucosa and olfactory bulbs in APP/PS1 mice was significantly shorter than WT at 12 months (Thomas et al., 2009) have previously shown that restriction on micronutrients or calorie has a great influence on MN frequency (Guo et al., 2017;Guo, Dai, et al., 2019;Guo, Qi, et al., 2021;Guo, Su, et al., 2023;Hu et al., 2020;Li et al., 2022;Yan et al., 2020). ...
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... Slides were smeared and then stained using eosin staining solution (Beyotime, China). Using a double-blind procedure, 1,000 polychromatic erythrocytes cells were observed from each mouse Guo et al., 2021). ...
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... On the other hand, mLOY in men at younger ages, although rare, is likely to underlie infertility and developmental defects [8] (Figure 1). In recent years, multiple epidemiological studies have shown that mLOY in somatic cell subsets at different stages of postzygotic development and throughout life is associated with mortality factors in males and serves as a marker for early detection of disease [9]. Genes of great relevance to these aspects have been observed, such as DDX3Y, which modulates cell differentiation development [10], and long non-coding RNAs promote the development of prostate cancer and play a role in processes important for the development of fatty liver, cellular inflammation due to atherosclerosis, and cardiovascular diseases [4]. ...
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... Since we have shown that a strong genotoxic stress is induced by long-term treatment of Hcy in SH-SY5Y cells (Hu et al., 2020), we aimed to determine the short-term effect of Hcy in present study. In each treatment, HUVECs were treated by Hcy for 24 h because they have a population doubling time less than 24 h (Yan et al., 2020). After 24 h, all treatments were completed and the cells were prepared for the cytokinesis-block micronucleus cytome (CBMN Cyt) assay. ...
