Jian Gong's research while affiliated with Capital Medical University and other places
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Publications (60)
Objective
Intracranial lesions in children often have good prognoses, allowing long-term survival. Cognitive functions, crucial for life quality, need more attention. Previous research has focused on adults, with pediatric studies limited by varied lesions and complex treatments. This study aims to evaluate cognitive and brain network changes in ch...
Numerous techniques excel in brain tumor segmentation using multi-modal magnetic resonance imaging (MRI) sequences, delivering exceptional results. However, the prevalent absence of modalities in clinical scenarios hampers performance. Current approaches frequently resort to zero maps as substitutes for missing modalities, inadvertently introducing...
Background
Craniopharyngiomas are low‐grade malignancies (WHO I) in the sellar region. Most cases of childhood‐onset craniopharyngioma are adamantinomatous craniopharyngioma, and neurosurgery is the treatment of choice. Affected patients have postoperative complications, including water and electrolyte disturbances, because these malignancies devel...
We explored the structural and functional changes of the healthy hemisphere of the brain after surgery in children with intracranial space-occupying lesions. We enrolled 32 patients with unilateral intracranial space-occupying lesions for brain imaging and cognitive assessment. Voxel-based morphometry and surface-based morphometry analyses were use...
This study examines functional brain network changes in children with frontal lobe tumors (FLT). Ten pediatric FLT patients from Beijing Tiantan Hospital and 20 healthy children were compared in terms of cognitive performance and resting-state functional magnetic resonance imaging (rs-fMRI) connectivity. The FLT group showed lower cognitive perform...
To develop a dynamic nomogram containing radiomics signature and clinical features for estimating the overall survival (OS) of patients with medulloblastoma (MB) and design an automatic image segmentation model to reduce labor and time costs.
Data from 217 medulloblastoma (MB) patients over the past 4 years were collected and separated into a train...
Objective
Hypothalamic-pituitary axis dysfunction is a common complication in post-operative craniopharyngioma(CP) patients, and it greatly impacts the long-term quality of life of such patients. To better understand the effects of postoperative hypothalamic-pituitary dysfunction and long-term hormone replacement therapy in patients with childhood...
Background
To assess the cognitive function changes and brain network neuroplasticity in school-age children having large (diameter > 5 cm) left middle fossa arachnoid cyst (MFACs).
Methods
Eleven patients and 22 normal controls (NC) between 6 and 14 years of age were included. The CNS Vital Signs (CNS VS) were administered for cognitive assessmen...
Background: Medulloblastoma (MB) is a highly malignant neuroepithelial tumor occurring in the central nervous system. The objective of this study was to establish an effective prognostic nomogram to predict the overall survival (OS) of MB patients.
Materials and methods: The nomogram was developed using data from a retrospective cohort of 280 medul...
Post-operative hydrocephalus is common among children with medulloblastoma after initial tumor resection. This study aimed to establish a novel model for predicting the development of post-operative hydrocephalus in children with medulloblastoma. Only pediatric patients who received initial medulloblastoma resection at Beijing Tiantan Hospital betw...
Background
Gliomas, the most prevalent primary malignant tumors of the central nervous system in adults, exhibit slow growth in lower-grade gliomas (LGG). However, the majority of LGG cases progress to high-grade gliomas, posing challenges for prognostication. The tumor microenvironment (TME), characterized by telomere-related genes and immune cell...
To explore the characteristics of the immune microenvironment (IME) of medulloblastoma (MB) by four methods: flow cytometry (FCM), immunohistochemical (IHC), bulk RNA expression and single cell RNA sequencing (scRNA-seq), we collected the intraoperative specimens of MB, ependymoma (EPN), high-grade glioma (HGG), and low-grade glioma (LGG) to make a...
Background
Primary central nervous system lymphoma (PCNSL) in pediatric patients presents diagnostic and treatment challenges, leading to delays and suboptimal strategies. Moreover, PCNSL in immunocompetent pediatric patients is rarely reported. This retrospective study aimed to describe the demographic and clinical features, as well as outcomes, o...
Background
Low-grade frontal lobe tumors (LGFLT) can be cured through total resection, but surgical trauma could impair higher-order cognitive function. We aim to characterize the short-term natural cognitive recovery and brain plasticity in surgically-treated pediatric patients with LGFLT.
Methods
Ten pediatric patients with LGFLT were enrolled....
Background:
A fast and reliable neurocognitive assessment tool is required for pediatric patients with an intracranial space-occupying lesion (ICSOL).
Methods:
A cross-sectional study was conducted on 41 pediatric patients having ICSOL. Cognitive abilities were assessed using both WISC-IV and CNS Vital Signs (CNS VS). All domains are compared to...
Background
To describe the epidemiological characteristics of central nervous system (CNS) tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital.
Methods
From January 2015 to December 2019, 3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization (WHO) classificatio...
Introduction:
Middle fossa arachnoid cyst (MFAC) is one of the most common cranial cysts in children, and the various postoperative complications following cyst fenestration represent a major concern. We conducted a retrospective study in our department and performed a systematic review of the literature to identify the risk factors for complicati...
We explored the structural and functional changes of the healthy hemisphere of the brain after surgery in children with intracranial space-occupying lesions. We enrolled 32 patients with unilateral intracranial space-occupying lesions for brain imaging and cognitive assessment. Voxel-based morphometry and surface-based morphometry analyses were use...
Background
Studies on cognition and brain networks after various forms of brain injury mainly involve traumatic brain injury, neurological disease, tumours, and mental disease. There are few related studies on surgical injury and even fewer pediatric studies. This study aimed to preliminarily explore the cognitive and brain network changes in child...
[This corrects the article DOI: 10.3389/fneur.2020.00766.].
Introduction
Almost 50% of children with intracranial ependymoma experience disease relapse, and their outcomes are extremely poor. The aim of this study was to investigate optimal salvage treatment for pediatric intracranial ependymoma after the first relapse and to identify prognostic factors affecting survival.
Methods
We conducted a retrospect...
Hypertensive brainstem hemorrhage (HBSH) is of high morbidity and mortality rate. But many clinical studies were written in Chinese and had not been reviewed. A systemic review of Chinese clinical studies for HBSH was performed. A systemic literature search in PubMed, Web of Science, China National Knowledge Infrastructure, and Weipu database and W...
Background
Studies on cognition and brain networks after various forms of brain injury mainly involve traumatic brain injury, neurological disease, tumours, and mental disease. There are few related studies on surgical injury and even fewer pediatric studies. This study aimed to preliminarily explore the cognitive and brain network changes in child...
Background:
Postoperative peritumoral brain edema (PTBE) is the progressively exacerbating cerebral edema following meningiomas resection.
Objective:
The study aims to identify the predictive factors of postoperative PTBE.
Materials and methods:
A retrospective study was conducted on the 117 cases of patients who underwent meningioma. The hist...
Craniofacial malformation caused by premature fusion of cranial suture of infants has a serious impact on their growth. The purpose of skull remodeling surgery for infants with craniosynostosis is to expand the skull and allow the brain to grow properly. There are no standardized treatments for skull remodeling surgery at the present, and the posto...
Purpose Middle fossa arachnoid cyst (MFAC) is one of the most common cranial cysts in children. The various postoperative complications following cyst fenestration are still the major concern for most surgeons. We systemically review the short-term postoperative complications in the literature and introduce our experience in preventing these compli...
Objective: To describe the epidemiological characteristics of central nervous system tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital.
Methods: From January 2015 to December 2019, 3 180 children were histopathologically diagnosed with central nervous system tumors based on the 2016 World Health Organization class...
Objective
This study aimed to investigate the factors impacting time to diagnosis in pediatric central nervous system tumors.
Methods
A descriptive, cross-sectional design was used in this study. A self-developed questionnaire for health-seeking behavior and influencing factors was used in children with intracranial tumors. The factors related to...
Medulloblastoma is a common pediatric malignant brain tumor. There were four consensus molecular subgroups (WNT, SHH, Group3 and Group4). Group 3 and Group 4 tumors exhibited a great degree of transcriptional overlap, and were neither derived from exact pathway aberration. We investigated transcriptional and chromatin accessibility of medulloblasto...
BACKGROUND
Pediatric pleomorphic xanthoastrocytoma (PXA) is a rare brain tumor. To date, there are very few studies dedicated to this kind of pediatric tumor. The aim of this study was to investigate the clinicopathological characteristics of pediatric PXA.
METHODS
We retrospectively analyzed 17 pediatric patients diagnosed with PXA histologically...
Objective
Common treatments for obstructive hydrocephalus caused by malignant midline intracranial tumors during the perioperative period include ventriculoperitoneal shunt (VPS) placement/endoscopic third ventriculostomy (ETV) and direct tumor resection, but which of these treatments is superior remains unclear. The purpose of this study is to exp...
Importance:
Cancer is the main cause of death by disease in children. Children experience the highest incidence of cancer in the first year of life. However, there is no comprehensive registration system for children with tumors in China.
Objective:
To summarize the diagnosis and treatment of infant cancer and analyze the status of standardized...
Background: The role and effectiveness of primary surgical treatment for sporadic chiasmatic–hypothalamic glioma (CHG) are not clear. The present study was to describe sporadic CHG visual acuity (VA) outcomes after surgery and to analyze the relevant factors affecting VA improvement.
Methods: Forty-five pediatric sporadic CHG patients who met the i...
Object The purpose of this study is to investigate clinical, pathological, and prognostic discrepancies between infantile and non-infantile desmoplastic astrocytoma / ganglioglioma patients.
Methods
From January 2012 to Dec 2019, we retrospectively reviewed patients younger than 18 years who underwent craniotomies at Beijing Tiantan Hospital. Pati...
Pineal region tumors have different pathological tumors and their optimal management remains controversial. Advancements in neuroendoscopy have led to the ability to simultaneously treat the hydrocephalus and obtain a tissue diagnosis. A retrospective review of 34 patients with pineal region tumors in Beijing Tiantan hospital from the year 2016 to...
Currently, there are few studies on cognitive impairment caused by neurosurgery, and there have been no studies on cognitive impairment after resection of lateral ventricular tumors in children. Previously, our research team has reported that the frontal transcortical approach can impair cognitive function. In this study, we explored which function...
Objective:
To investigate the expression of H3K27me3 in different anatomical sites and analyze its prognostic value in children with ependymoma.
Methods:
A total of 188 children diagnosed with ependymoma were admitted to the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, between 2012 and 2017, and regular follo...
Background:
Many neurophysiological diseases during infancy stage are associated with the morphology and size of the lateral ventricle. This research aims to measure the normal value range of lateral ventricle volume of normal infant and thus provide basic data for clinical treatment.
Method:
By retrospective analysis of magnetic resonance inspe...
Background: External ventricular drainage (EVD) is common after brain surgery. However, the incidence of EVD-related infection (ERI) is still relatively high and can increase morbidity and mortality.
Objective: The objective of this study was to analyze ERI factors in pediatric population post-brain tumor surgery.
Methods: From January 2016 to Dece...
Purpose
To establish some explicit, feasible, and reproducible predictors for CMS.
Materials and methods
This study was a retrospective case study. Data were obtained from 82 patients with medulloblastoma at a single center, Beijing Tiantan Hospital. Based on medical records, we created two independent samples: the CMS group comprising 23 patients...
Currently, there are few studies on cognitive impairment caused by neurosurgery, and there have been no studies on cognitive impairment after resection of lateral ventricular tumors in children. Previously, our research team has reported that the frontal transcortical approach can impair cognitive function. In this study, we explored which function...
Introduction:
Gunshot penetrating brain injury is common in military conflict area and in urban violence area, but similar incident in pediatric population is rarely reported.
Case report:
We reported three cases of gunshot penetrating brain injury in children. Two patients had a good recovery after surgery and no significant deficit on his neur...
Background:
Pineoblastoma is a rare malignant tumor of the pineal gland, which is more common in children.
Methods:
We retrospectively reviewed 18 cases of pineoblastoma in children (10 girls), including general, clinical, and therapeutic information, and factors affecting prognosis.
Results:
The median age of the children was 51.7 months (ran...
Object
The tumor described in this report was unique because of its involvement with a posterior fossa spontaneous hemorrhage in a pediatric patient; such a case has never been previously described in cases of pilomyxoid astrocytomas and also rarely found in those of pilocytic astrocytomas.
Methods
This report studied a rare case of posterior fo...
Glioma is the most common intracranial malignant tumor. Low-grade gliomas (LGG) occupy almost 80% in all of the gliomas. The prognosis of LGG in children is much better than in adult, however, the molecular mechanism is still unclear. In our investigation, it was first found that the level of soluble IL1RAP (sIL1RAP) was significantly higher in the...
Objective:
Applying frontal transcortical approach to treat lateral ventricular tumor is one of the most common neurosurgical manipulations. The frontal transcortical approach generally passes through the middle frontal gyrus in which there is no major function involved in the traditional sense. However, current researches have suggested that the...
Object:
Primary intracranial germinoma is a rare intracranial lesion which accounts for approximately 0.5-2% of all intracranial tumors. Generally, primary intracranial germinoma occurs in the midline structures of the central nervous system of a pediatric patient. Only four cases of primary cerebellar germinomas with poor prognosis have been prev...
Objective:
The feasibility and prognosis of surgical treatment for children with OPGs is controversial. Therefore, this study attempted to evaluate the effects of surgery and discuss prognostic factors related to the survival of children with symptomatic OPGs.
Materials and methods:
One hundred twenty-five children diagnosed with OPGs underwent...
Objective:
Surgical removal plays an important role in treating children's craniopharyngioma. For a safe and minimally invasive craniotomy, a reformed surgical modality was proposed in this paper by combining the insertion of an Ommaya reservoir system (ORS) by stereotactic puncture, aspiration of cystic fluid in 2-day interval for consecutive 7-1...
Methods:
The aim of this study is to compare preoperative strategy integrating computer-assisted 3D simulation and biomechanical calculation and traditional strategy. A retrospective method was used to compare the effect and difference between these 2 strategies. The clinical data of 18 patients with sagittal synostosis were collected and compared...
Objective:
The survival rate and prognosis in infants with giant intracranial tumors is significantly worse than in older children. This study aimed to analyze the feasibility of delayed-operation for infants with giant intracranial benign tumor by evaluating the initial clinical presentations, expectant treatment measures, perioperative vital sig...
Background:
Adamantinomatous craniopharyngioma (ACP) is a benign but maldevelopmental tumor with a high recurrence rate.
Objective:
Theaim of this study was to investigate the dysregulated biological molecules that play important roles in the recurrence of ACP.
Methods:
We first performed microarray analysis on tumor samples from two pediatric...
Hypothalamic hamartoma (HH) is a rare condition that often manifests as central precocious puberty (CPP). There is a lack of information available concerning the long-term effectiveness of surgery for the treatment of CPP due to HH. Here the authors describe 3 cases of CPP due to HH, with a follow-up ranging from 9 to 11 years after surgery. Three...
To explore the expression of matrix metalloproteinase 9 (MMP-9), type IV collagen (Col IV) and vascular endothelial growth factor (VEGF) in adamantinomatous craniopharyngioma (ACP) and analyze the correlation between the level of these markers and adamantimous craniopharyngiomas recurrence. Expressions of MMP-9, Col IV and VEGF were tested by immun...
To report an approach for removing the medial type of thalamic gliomas.
Eight cases of medial type of thalamic gliomas, 4 males and 4 females, aged 22 (14 approximately 53), underwent resection of the tumor by transcallosal interforniceal approach: right frontal craniotomy, along the cerebral midline natural cleft to reach the third ventricle.
By u...
Citations
... www.nature.com/scientificreports/ In previous studies, Guo et al. 7 and Zhou et al. 5 utilized Cox proportional hazard regression for survival analysis of medulloblastoma and developed a nomogram. Compared with their study, the C-index values obtained from the DeepSurv model were higher in both the training and the testing cohort, indicating its superior predictive accuracy of the prognosis of patients with medulloblastoma. ...
... We read with great interest the article by Miao et al. (1) reporting the long-term results of patients who underwent surgery for childhood-onset (CO) craniopharyngioma (CP). The number of patients included in the study is impressive, with 200 CP patients having CO. ...
... Motor and cognitive deficits caused by PFT can be remediated [26]. A developing child's brain has the potential to compensate for some of the cancer-induced deficits [27]. Currently, rehabilitation programs for pediatric brain tumor survivors are being created, often integrating modern technologies [28]. ...
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... 8 Various treatment methods for symptomatic arachnoid cysts have been described, including craniotomy for cyst drainage and/or resection, 6,8,9 as well as microsurgical or endoscopic cyst fenestration. 3,18,19 Previous prospective studies have found that surgery for arachnoid cyst treatment is relatively safe and can yield significant clinical benefit in both children and adults. 1,20 Cystoperitoneal shunting is another surgical option for these patients and has been described in prior cases of symptomatic arachnoid cysts. ...
... 36,37 The ON is located in the occipital lobe and is mainly involved in visual processing. 38 Our results showed the reduced network connectivity between SMN and ON and significant impairment of visuospatial/executive capacity after mTBI, suggesting that intrinsic inactivation and reduced efficiency of SMN and ON may be one of the reasons for the decreased visual spatial/executive capacity after mTBI. However, we did not find a significant association between SMN-ON connectivity of the CBF network and cognitive performance, which may be due to the limited sample size or the severity of cognitive impairment in the mTBI group. ...
... In addition to gliomas and medulloblastomas, other studies have reported craniopharyngiomas and ependymomas among the most frequent pediatric tumors [6]. Most pediatric tumors in this study were benign, like other studies [36]. In this study, gliomas were the most common benign pediatric BTs, whereas medulloblastomas were the most malignant brain pediatric tumors. ...
... In retrospective cohort studies, recurrent surgical resection has shown mixed evidence related to the impact on overall survival [3,14,16]. A recent multi-center study of locally recurrent infratentorial pediatric ependymoma showed GTR at first recurrence was associated with improved OS [17]. Chemotherapy for recurrent ependymoma has not shown convincing survival benefit, though in young patients has been considered for radiation-sparing purposes [18]. ...
... One of the common causes of postoperative brain edema and contusion is sacrifice of cortical veins or their prolonged compression with fixed retractors. [30][31][32] Advocating a unifrontal approach, Romani et al. [25] reported no postoperative increase in brain edema or venous infarction following excision of TSM via a lateral supra orbital approach. ...
... (Yellow part is for the personalization marker, green part is for preoperative plan and blue part is for the intraoperative navigation.) [21], [22]. This part details the algorithm of steel balls recognition and registration by the designed marker talked above. ...
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... The management of PPH remains a subject of debate among medical practitioners. Despite over a century of examination, no universal consensus has been reached [12]. The widely recognized guidelines published by the American Heart Association/American Stroke Association (AHA/ASA) and the European Stroke Organization do not provide clear specifications for the diagnosis and treatment of PPH, and the AHA/ASA guidelines specifically discourage surgical intervention [13,14]. ...
