Jessica Hotaling's research while affiliated with State University of New York Upstate Medical University and other places
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Publication (1)
Actin and microtubules play essential roles in aberrant cell processes that define and converge in cancer including: signaling, morphology, motility, and division. Actin and microtubules do not directly interact, however shared regulators coordinate these polymers. While many of the individual proteins important for regulating and choreographing ac...
Citations
... The profilin 1 (PFN1) variants (A20T, C71G, T109M, M114T, E117G, G118V, R136W, and Q139L) cause the autosomal dominant form of ALS by interfering with the actin dynamics in two opposite pathways. Firstly, PFN1 directly binds to the actin monomers, blocking the sites for new monomer addition, and thus preventing the actin filament assembly (Pimm et al., 2020;Liu et al., 2022). Secondly, PFN1 enhances the actin filament assembly by interacting with PFN, a profilamentous actin-binding protein (Schmidt et al., 2021). ...
