Jeong-Jae Ko's research while affiliated with CHA University and other places
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Publications (6)
Drug resistance in breast cancer remains a major obstacle of clinical therapy. We found that suppression of ELK3 in the triple negative breast cancer cell line MDA-MB-231 impaired autophagy and led to a hypersensitive response to doxorubicin treatment. In ELK3-knockdown MDA-MB-231 cells (ELK3 KD), autophagy was not activated under starvation condit...
Rad51 is a key component of homologous recombination (HR) to repair DNA double-strand breaks and it forms Rad51 recombinase filaments of broken single-stranded DNA to promote HR. In addition to its role in DNA repair and cell cycle progression, Rad51 contributes to the reprogramming process during the generation of induced pluripotent stem cells. I...
Sprouty (Spry) genes encode inhibitors of the receptor tyrosine kinase signaling cascade, which plays important roles in stem cells. However, the role of Spry4 in the stemness of embryonic stem cells has not been fully elucidated. Here, we used mouse embryonic stem cells (mESCs) as a model system to investigate the role of Spry4 in the stem cells....
The tumor suppressor protein p53 is unstable in quiescent cells and undergoes proteosomal degradation. Under conditions of cellular stress, p53 is rapidly stabilized by post-translational modification, thereby escaping degradation and translocating to the nucleus where it activates genes related to cell cycle arrest or apoptosis. Here, we report th...
G9a is a lysine methyltransferase (KMTase) for histone H3 lysine 9 that plays critical roles in a number of biological processes. Emerging evidence suggests that aberrant expression of G9a contributes to tumor metastasis and maintenance of a malignant phenotype in cancer by inducing epigenetic silencing of tumor suppressor genes. Here, we show that...
Citations
... This data suggests that cellular reprogramming is sensitive to intrinsic cell state cues and drives a restoration of homeostatic function and youthful molecular phenotypes. Similarly, in vivo partial reprogramming studies show a more robust improvement to lifespan in progeria models indicating an ability to respond to deleterious cell states (Ocampo et al., 2016;Alle et al., 2022) Previously, it was shown improved DNA repair via overexpression of the HR protein Rad51 enhances reprogramming efficiency (Lee et al., 2016). In our 4F Ercc1 fibroblasts, we observed the most significant reprogramming-induced rejuvenation coincided with upregulation of multiple DNA repair pathways. ...
... The hiPSC line BC1 [14] was obtained from the NIH Center for Regenerative Medicine. hiPSCs were maintained on a feeder-free layer condition with Matrigel (Corning; AZ, USA) in mTeSR1 media (STEMCELL Technologies; Canada), where only passage numbers [30][31][32][33][34][35][36] were used for subsequent culture and experiments. hiPSCs were differentiated towards a neural progenitor lineage (hiPSC-NPC) using dual SMAD inhibition in a monolayer. ...
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... The PI3K pathway is essential for regulating cell survival, growth, and differentiation (Kamal et al., 2016;Park et al., 2016). And the signal pathway can response to ROS (W. ...
... 32,33 However, it is crucial to note that, unlike those proteins with a singular disease-related function, members of the ELL protein family have diverse roles in diseases, extending beyond positive transcriptional regulatory functions, such as targeting c-Myc for proteasomal degradation, inhibition of some oncogenes expression, promotion the degradation of p53. 32,[34][35][36][37][38] Therefore, a comprehensive understanding of the specific roles of the ELL protein family in various diseases will require more in-depth researches in the future (Figure 1). ...
Reference: SEC: A core hub during cell fate alteration
... As proof, several Sox2 modifications, namely phosphorylation, acetylation, methylation, ubiquitination, sumoylation, have been noted in regulating diverse cellular processes [102][103][104][105][106][107]. Lee et al. (2015) [108] explored the action of a lysine-methyltransferase-G9a in adjusting Sox2 protein levels in response to G9a expression. Sox2 protein accumulation or reduction was reported upon G9a ectopic expression or inhibition, respectively, in ER-positive BrCa cell line, without affecting Sox2 transcript levels. ...
