Jean Perrin's scientific contributions

Publications (2)

Article
It was recently well established that the vagal intestinal glucoreceptors are involved in insulin release. In this work we demonstrate that the splanchnic glucoreceptors play a unique role in insulin release: their activation induces a decrease, like strong mechanical stimulation. The physiological meaning of this effect is not clear, it may be a n...
Article
In anesthetized cats, the unitary activity of splanchnic sensory neurons were recorded from T9, T10 and T11 spinal ganglia by means of extracellular glass microelectrodes. Twelve neurons, generally silent, were activated by perfusion of jejuno-ileum with glucose solutions (10, 50, 100 or 200 g/l). The responses indicated that the corresponding rece...

Citations

... To date, reporter mice with fluorescently labeled neurons and RNA-Seq have not been applied to the investigation of the innervation patterns in abdominal and other relevant organs, or to investigation of the potential roles of postganglionic SNS and DRG neurons in nutrient sensing and metabolic control. One recent study reported that the duodenal-glucose-induced drop in hypothalamic agouti-related peptide neuron activity was significantly attenuated in mice with prior celiac/superior mesenteric ganglionectomy, while the duodenal-fat-induced drop was attenuated in mice with subdiaphragmatic vagotomy (83), which may be explained by some of the functional differences between vagal and splanchnic glucosensors reported earlier (88). Whether these findings can be confirmed with more selective manipulations remains to be seen. ...
... It is widely accepted that nociceptive information is relayed centrally via spinal afferent neurons while visceral reflex and integrative functions are transmitted by vagal afferents. Several lines of evidence, however, indicate that spinal visceral afferents are also activated by low pressure distention and innocuous chemical stimulation and therefore may also relay non-nociceptive information centrally (250,375,398) while vagal afferents also respond to noxious stimulation (490,491). This convergence of vagal and spinal afferent sensory inputs within the NTS allows a significant degree of overlap between the integration and processing of sympathetic and parasympathetic visceral information. ...