Jean-Jacques Dubost's research while affiliated with Polytech Clermont-Ferrand and other places
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Publications (352)
Background
Primary Sjögren Syndrome (pSS) patients have an increased risk of Non-Hodgkin lymphoma (NHL). There is no consensus on the therapeutic management of low-grade NHL. Two strategies can be proposed; either a ‘‘wait and see’’ strategy or an active therapeutic strategy.
Objectives
To describe characteristics of NHL in pSS, therapeutic strate...
Objective: Post-traumatic stress disorder (PTSD) may be a risk factor for the development of rheumatoid arthritis (RA). No data are available in spondyloarthritis (SpA). The aim of the present study was to investigate the frequency of traumatic events and PTSD in patients with SpA and its different phenotypes, and to compare the results to patients...
Septic arthritis (SA) and gout are the main suspected etiologies of acute monoarthritis. Differentiating them is essential because SA is an emergency. The performance of a gout diagnostic score developed by Janssens et al. was investigated in a cohort of patients with acute arthritis suspected of being septic. This was an ancillary study of a singl...
Background
Tropheryma whipplei (Tw) infection is a rare condition, characterized by inflammatory joint symptoms in more than 75% of the cases, which can lead the physician to diagnose chronic inflammatory rheumatic diseases (IRD) and to initiate DMARDs. DMARDs are often ineffective and may reveal digestive signs, systemic manifestations or involvem...
Résumé
L’association sécheresse des yeux et de la bouche, fatigue et douleurs des membres évoque un syndrome de Sjögren primaire (SSp) qui est une maladie auto immune systémique. L’association caractérise aussi le Syndrome Asthénie Polyalgie Sécheresse (SAPS) qui est considéré comme un équivalent de fibromyalgie et elle est fréquente dans la fibrom...
Resumen
La espondilodiscitis es una infección del disco y los platillos vertebrales adyacentes, como resultado de una diseminación hematógena o, más raramente, de una inoculación directa a través de un procedimiento local (punción, infiltración) o de cirugía discal. Los gérmenes implicados son diversos: estafilococos (50%), pero también bacilos gra...
Introduction
L’infection à Tropheryma whipplei (Tw) débute chez la majorité des patients par des manifestations rhumatologiques isolées, pouvant conduire à un diagnostic de rhumatisme inflammatoire chronique (RIC) justifiant l’initiation d’un DMARD. Le traitement de l’infection à Tw pourrait avoir un impact favorable sur les manifestations rhumatol...
Introduction
Le syndrome de stress post traumatique (SSPT) pourrait être un facteur de risque de développer une polyarthrite rhumatoïde (PR). On ne dispose pas de données dans les spondyloarthrites (SpA). L’objectif de l’étude est d’évaluer la prévalence des traumatismes et du SSPT chez des patients atteints de SpA et ses différents phénotypes, et...
Objectives:
Dryness, fatigue, and pain are classic symptoms in primary Sjögren's syndrome (pSS) but are also common in fibromyalgia (FM). We compared the characteristics of FM assessed by different criteria (American College of Rheumatology (ACR) 2016 and 1990 criteria), physician's opinion and Fibromyalgia Rapid Screening Tool (FiRST) questionnai...
Résumé
Objectif : Déterminer la prévalence et les caractéristiques de l’atteinte dermatologique dans le syndrome de Sjögren primitif (SSp).
Méthodes : Nous avons utilisé 2 cohortes françaises de SSp (ASSESS, qui a évalué la prévalence des atteintes cutanées chez 395 patients atteints de SSp ; et diapSS, dans laquelle 76 sur 139 patients atteints de...
Résumé
Aucun germe n’est identifié dans près de 20 % des arthrites septiques (AS). Certaines études montrent que AS avec ou sans germe identifié sont identiques et doivent être traitées de la même façon alors que d’autres suggèrent que si les caractéristiques cliniques sont identiques, le pronostic des AS sans germe est meilleur et que ce groupe es...
Objective: To determine the prevalence and significance of dermatological disorders in primary Sjögren syndrome (pSS).
Methods: We used 2 pSS French cohorts (ASSESS, in which prevalence of skin disorders in 395 patients was evaluated; and diapSS, in which 76 on 139 pSS patients had an examination by a dermatologist) and baseline data of the TEARS r...
Introduction
Les atteintes cutanées sont habituelles au cours du syndrome de Gougerot-Sjögren primitif (SSp), mais leur prévalence et leurs caractéristiques sont difficiles à établir précisément en raison du nombre limité de patients étudiés dans la plupart des cohortes, de la variabilité des signes fonctionnels et cliniques évalués dans chaque coh...
Objectives:
To refine the prevalence, characteristics and response to treatment of myositis in primary SS (pSS).
Methods:
The multicentre prospective Assessment of Systemic Signs and Evolution in Sjögren's Syndrome (ASSESS) cohort of 395 pSS patients with ≥60 months' follow-up was screened by the 2017 EULAR/ACR criteria for myositis. Extra-muscu...
To investigate the physiopathology of pain in chronic inflammatory rheumatic diseases (CIRDs), we assessed the prevalence of migraine and neuropathic pain in 499 patients with CIRDs. We studied 238 patients with rheumatoid arthritis, 188 with spondyloarthritis (SpA), 72 with psoriatic arthritis (PsA), and 1 unclassified. Migraine was diagnosed acco...
Background
Rheumatoid arthritis (RA) is associated with an increased risk of non-Hodgkin B-cell lymphoma (B-cell NHL).
Objectives
1)To study the characteristics of B-cell NHL complicating RA
2)To identify the factors associated with their occurrence.
Methods
A multi-centre case-control study was performed in France. Cases were patients with RA fu...
Background
Cutaneous involvement is common during primary Sjogren’s Syndrome (pSS) but prevalence and characteristics are difficult to establish precisely because of the limited number of patients studied in most cohorts, the variability of the disorders evaluated in each cohort, the rarity of some of them, and the heterogeneity of evaluations from...
Résumé
L’atteinte rhumatologique, le plus souvent des arthrites récidivantes, est inaugurale dans les trois-quarts des cas de maladies de Whipple. Nous rapportons deux observations dans lesquelles la maladie de Whipple s’est manifestée par des bursites et des ténosynovites chroniques. Un homme de 42 ans avait une bursite olécrannienne bilatérale, u...
Joint complaints, most commonly intermittent arthritis, are the initial manifestation in about three-fourths of Whipple's disease cases. We herein report on two cases wherein Whipple's disease manifested itself as chronic bursitis and tenosynovitis at several sites. A 42 year-old man had bilateral olecranon bursitis, a right patellar bursitis and a...
Background
Modifications in ultrasonographic aspect of major salivary glands have been reported in patients with primary Sjogren Syndrom (pSS) with good diagnostic accuracy. Sicca symptoms are frequently observed in Systemic sclerosis (SSc).
Objectives
To assess the ultrasonographic echostructure of major salivary glands in patients with SSc and c...
Résumé
Les spondyloarthrites débutent principalement chez l’adulte jeune, cependant un début après 45 ou 50 ans n’est pas exceptionnel. La répartition du type de spondyloarthrite diffère chez le sujet âgé et notamment le rhumatisme psoriasique devient très prépondérant à cet âge. L’expression clinique des spondyloarthrites à début tardif est aussi...
La artritis séptica es el resultado de la invasión de la sinovial por microorganismos vivos tras una diseminación hematógena o una inoculación por regla general iatrogénica: infiltración o cirugía articular. La incidencia está estimada entre 1-10 por cada 100.000 habitantes al año. Está favorecida por la edad avanzada, la artritis reumatoide, la di...
Objectives:
Onset of primary SS is usually between 40 and 60 years of age, with severe systemic complications in 15% of cases. We sought to determine whether early-onset disease is related to a specific phenotype and if it is predictive of a poor outcome.
Methods:
Biological and clinical data from 393 patients recruited in the ASSESS cohort, a F...
Objective
To compare, in real‐life settings, the retention rates of initial anti‐tumor‐necrosis factor (TNF) treatments (etanercept [ETN], adalimumab [ADA] and infliximab [IFX]) used as first‐line biotherapy for axial spondyloarthritis (axSpA), and evaluate treatment switches to another anti‐TNF inhibitor in the event of treatment failure.
Methods...
Objectives:
To evaluate the short-term efficacy of vitamin D (cholecalciferol) supplementation on functional disability in RA patients.
Methods:
1) Patients: RA (ACR 1987 revised criteria) in non-remission (DAS28 >2.6) whose treatment was not expected to be changed over a 3-month period following inclusion and presenting with vitD deficits (seru...
The number of elderly people with chronic inflammatory rheumatic diseases is increasing. This heterogeneous and comorbid population is at particular risk of cardiovascular, neoplastic, infectious and iatrogenic complications. The development of biotherapies has paved the way for innovative therapeutic strategies, which are associated with toxicitie...
Background
Myositis prevalence in primary Sjögren’s syndrome (pSS) and whether it is associated with peculiar extra-muscular involvement and/or a biological profile is unknown.
Objectives
To refine prevalence and characteristics of patients with pSS and myositis.
Methods
In the national multicenter prospective cohort ASSESS (395 patients with pSS...
Background
Diagnosing septic arthritis (SA) is an emergency, and for a diagnosis to be made a microorganism must be found in the synovial fluid or blood culture. Besides direct bacteriological examination, which is positive in only 25% to 50% of cases, no laboratory examination can differentiate SA from other forms of arthritis.
Objectives
To asse...
Background
The treatment of rheumatoid arthritis (RA) is aimed to achieve remission.
Objectives
To determine the proportion of RA patients in remission among the population treated by rheumatologists in Auvergne, France.
Methods
A 3 month survey involving 24 rheumatologists, not practicing at university hospitals, from the Auvergne region of Fran...
Background
The use of TNF-α inhibitors, has considerably improved the treatment of rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA). The most widely used anti-TNFs are infliximab (IFX), adalimumab (ADA), and etanercept (ETN). Their efficacy and safety have been demonstrated in randomised controlled trials, though of...
Background and objective
The incidence of infectious spondylodiscitis has been shown to rise with age; however, they had not been extensively investigated in the very elderly.
Material and methods
This retrospective, monocentric study included patients hospitalized in our department of rheumatology for primary infectious spondylodiscitis between 2...
Background
Coagulase-negative staphylococci (CoNS) are increasingly implicated in recent patient series of spondylodiscitis, but there are no series of CoNS-spondylodiscitis available. The objective of this study was to compare the characteristics of patients with spontaneous CoNS-spondylodiscitis with those patients with Staphylococcus aureus (SA)...
Background and objetive:
The incidence of infectious spondylodiscitis has been shown to rise with age; however, they had not been extensively investigated in the very elderly.
Material and methods:
This retrospective, monocentric study included patients hospitalized in our department of rheumatology for primary infectious spondylodiscitis betwee...
Objective:
To compare, in real-life conditions, the retention rates of anti-tumor necrosis factor (anti-TNF) treatment (etanercept [ETN], adalimumab [ADA] and infliximab [IFX]) initiated as first-line biotherapy for rheumatoid arthritis (RA) and to evaluate, in case of failure, the switch to another anti-TNF or a non-anti-TNF biological.
Methods:...
Background:
An interferon (IFN) signature is involved in the pathogenesis of primary Sjögren's syndrome (pSS), but whether the signature is type 1 or 2 remains controversial. Mouse models and genetic studies suggested the involvement of T helper 1 and type 2 IFN pathways. Likewise, polymorphisms of interleukin 12A gene (IL-12A), which encodes for...
Résumé
Objectif
Rechercher des modifications de la fréquence et des caractéristiques des arthrites septiques (AS) compliquant une polyarthrite rhumatoïde (PR) au cours des 35 dernières années.
Méthodes
Cette étude rétrospective monocentrique a inclus tous les patients hospitalisés dans le service de rhumatologie entre 1979 et 2013 pour une AS bac...
Background
Evaluation of sarcopenia is of major relevance because of these clinical repercussions on morbidity and mortality. Although the definition should include both low muscle mass and function, a combination of the 2 criteria was not reported in inflammatory rheumatic diseases (IRDs).
Objectives
To determine in a cohort of IRDs the prevalenc...
Objective:
Fibromyalgia (FM) is a confounding factor for diagnosing and assessing rheumatic disease activity. This study sought to assess the extent of this syndrome in rheumatism patients at a French rheumatology department.
Method:
This monocentric epidemiological study enrolled all patients consulting due to rheumatoid arthritis (RA), spondyl...
Objectives:
Reduction of LDL-cholesterol (LDLc) is essential to decrease the cardiovascular mortality in rheumatoid arthritis (RA). Between 2005 and 2010, French recommendations for dyslipidaemia defined the LDLc target based on the number of cardiovascular risk factors. In 2006, it was recommended to consider LDLc objectives with RA being counted...
Objectives:
While several registries have already evaluated the retention of anti-TNF therapy in psoriatic arthritis (PsA), they sometimes reach divergent conclusions. Our study therefore sought to assess therapeutic retention rates and predictive factors of response in a patient cohort from Auvergne, France, followed up in routine clinical practi...
Objective:
To evaluate the performance of the Fibromyalgia Rapid Screening Tool (FiRST) self-questionnaire for the detection of FM associated with inflammatory rheumatic diseases.
Methods:
This cross-sectional, French single-centre study was carried out between September 2014 and April 2015 in all patients who consulted for RA, SpA or CTD. Diagn...
Objectives
To identify the main determinants of quality of life (QoL) alteration in patients with active primary Sjögren's syndrome (pSS) participating in a large therapeutic trial.
Methods
At the inclusion visit in the TEARS trial, 120 patients with active pSS completed the Short Form survey 36 (SF36), a validated tool measuring the level of QoL....
Background
Prevalence of Sjogren's syndrome (SS) in inflammatory myopathies (IM) and whether IM patients with SS represent a distinct disease subset are currently unknown.
Objectives
To assess the signification of SS in IM with regard to phenotype and prognosis.
Methods
IM patients with SS (IM-SS group) were identified among a cohort of 270 patie...
Objectives:
To see whether the frequency and features of septic arthritis (SA) complicating rheumatoid arthritis (RA) have changed over the last 35years.
Methods:
This retrospective single-center study included all patients hospitalized at the rheumatology department for SA bacteriologically documented by synovial fluid and/or blood culture samp...
Background
Fibromyalgia (FM) is a prevalent syndrome in patients with inflammatory rheumatic disease.
Objectives
The purpose of this study was to evaluate and compare the prevalence of FM in various inflammatory rheumatic diseases.
Methods
This single-center cross-sectional study was conducted between September 2014 and April 2015. We screened fo...
Background
Rheumatoid arthritis (RA) is a risk factor for septic arthritis (SA), and anti-TNF therapy doubles the risk of SA.
Objectives
The purpose of this study was to see whether the frequency and features of SA complicating RA have changed over the last 35 years.
Methods
This retrospective single-center study included the full register of all...
Background
Primary Sjögren Syndrome (pSS) is an autoimmune disease mediated by B-cells as evidenced by the occurrence of non-Hodgkin lymphoma mainly involving salivary glands and increased B-cell activation markers in the serum of pSS patients. A type I interferon response is also observed among some patients. However, some mice models and large ge...
Background
Fibromyalgia (FM) is prevalent in patients with chronic inflammatory rheumatic diseases (CIRd), where it hampers diagnosis and activity assessment. No tool for screening FM associated with CIRd has ever been evaluated. The Fibromyalgia Rapid Screening Tool (FiRST) is a brief and simple self-complete questionnaire that has been validated...
Background
While several registries have already evaluated the retention of first-line anti-TNF therapy in RA, divergent conclusions have at times been reported. Following treatment failure with a first-line anti-TNF agent, a non-TNF-targeted biologic is recommended rather than a second anti-TNF drug.
Objectives
This study sought to compare the re...
Objectives Neurological manifestations seem common in primary Sjögren's syndrome (pSS) but their reported prevalences vary. We investigated the prevalence and epidemiology of neurological manifestations in a French nationwide multicentre prospective cohort of patients with pSS, the Assessment of Systemic Signs and Evolution in Sjögren's syndrome (A...
Aims and objectives:
Assess knowledge concerning methotrexate in rheumatoid arthritis patients by means of a questionnaire.
Background:
Methotrexate is the standard drug for rheumatoid arthritis treatment. It has potentially serious side effects that can be largely prevented by making sure that patients are well informed and comply with prescrip...
A germline and coding polymorphism (rs2230926) of TNFAIP3 (A20), a central gatekeeper of nuclear factor-kappa B (NF-kB) activation, was recently found associated with primary Sjögren's syndrome (pSS)-associated lymphoma in a French cohort. We aimed to replicate this association.
The rs2230926 polymorphism was genotyped in cases and controls of Euro...
Background Rheumatoid artritis (RA) is characterized by increased cardiovascular (CV) mortality and by a metabolic profile including obesity, cachexia, insulin resistance, dyslipidaemia. Traditional DMARDs as well as biologics decreases inflammation and could thus improve CV risk. However, the effects of such therapies on lipids and body compositio...
Background High throughput study of metabolic pathways might help identify new biomarkers and therapeutic targets in autoimmune diseases. Primary Sjögren's syndrome (pSS) currently lacks prognostic biomarkers and efficacious and specific treatments. We therefore assessed serum levels of 35 metabolites in pSS using high-resolution magic-angle spinni...
Background
Development of non-Hodgkin lymphoma (NHL) is one of the most severe complications associated with primary Sjogren's syndrome (pSS). Presence of ectopic germinal center (GC) in salivary glands biopsy is a predictor of NHL occurrence in pSS patients [1].
Objectives
Given the association between CCL11 and CXCL13 and ectopic GC, we decided...
Background Primary Sjögren syndrome (pSS) is an autoimmune disease which may be associated to several systemic manifestations. Neurological manifestations seem to be frequent but prevalence is inconstant in literature (1).
Objectives To assess neurological involvement prevalence in a national multi-center prospective cohort and to study epidemiolog...
Background Little is known about the pathogenesis of fatigue, a hallmark of primary Sjögren's syndrome. The respective contribution of depression, disease activity, or auto-immunity itself has never been studied ever since international disease activity scores were established. We therefore investigated the association between fatigue and other cha...
Background Diagnosing infectious spondylodiscitis is greatly facilitated by improved access to MRI testing. However, MRI testing increases the possibility of false positives. The efficiency of bacteriological testing is highly variable depending on the series performed, and this efficiency is not improving.
Objectives The objective of this study is...
Macro-creatine kinase (macro-CK) is a neglected cause of raised CK. Over a 10-year period, we observed five cases. Three patients had macro-CK type 1. One patient with fibromyalgia underwent several explorations to find a muscular pathology; another, who had elevated CK-MB (muscle-brain fraction) activity, was referred to a cardiologist, and statin...
To determine the sensitivity and specificity of clinical and laboratory signs for the diagnosis of septic arthritis (SA). Patients and methods This prospective study included all adult patients with suspected SA seen in the emergency department or rheumatology department at the University Hospital, Clermont-Ferrand, France, over a period of 18 mont...
Immune reconstitution inflammatory syndrome is a rare complication of the treatment of Whipple's disease. Here, we report the case of a 65-year-old man treated for Whipple's disease affecting the joints, with positive Tropheryma whipplei PCR in CSF, who developed fever and nodular eruption on the trunk, arms and face in association with biological...
As life expectancies rise, the number of elderly people with inflammatory rheumatic diseases will continue to grow. Treatment of this frail population, whose clinical features differ from those of younger subjects, poses new challenges to healthcare systems. However, this issue is rarely addressed in the current literature. Thanks to their targeted...
The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis) is a rare disease and only a few series have been published about it. We describe the experience of a rheumatology department with a focus on the therapeutic aspects.
All cases of SAPHO fulfilling the Benhamou criteria and seen between 1992 and 2013 in our unit were retrospect...
Citations
... Circulating IFN-α was significantly associated with autoantibodies and B-cell activation markers such as BAFF in patients with pSS [12]. ...
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... This study is limited by the fact that only baseline data were available for the analysis, with no follow-up data. In the French ASSESS cohort, the most frequent changes at follow-up were seen not only in the biological, articular, haematological and glandular domains, but also in the pulmonary domain [18]. Objective evaluation of this domain may require formal pulmonary function tests. ...
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... Публикаций, посвященных анализу распространенности ФМ при других системных заболеваниях соединительной ткани с ювенильным дебютом, как и при системных васкулитах у детей, мы не обнаружили. У взрослых пациентов распространенность ФМ при первичном синдроме Шегрена, по данным разных авторов, составляет от 12 до 31% [38][39][40], при болезни Бехчета -от 3,3 до 29,2% [40][41][42], при системном склерозе -от 6,67 до 30,3% [42,43], при первичном антифосфолипидном синдроме -16,7% [44]. ...
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... However, one of the interesting points of our study was the 6.2% of SAFJ without documented bacteriological evidence. This is much less than in other osteoarticular infections (7 to 34% [19][20][21][22]) and VO (9 to 35% [23][24][25]). One explanation could stem from difficulties in synovial fluid aspiration in the absence of effusion or abscess, and the challenges associated with performing synovial or bone biopsies on these small joints. ...
... Diagnostic suspicion of primitive Sjögren's Syndrome (DIApSS) is a single-center prospective cohort of patients suspected of having SjD included between January 2006 and July 2022 at the Brest University Hospital, France, as previously described. 15,16 Patients underwent a multidisciplinary standardized evaluation before inclusion. A total of 146 patients fulfilling the American College of Rheumatology/EULAR criteria for SjD were included. ...
... A diferencia de Ribbing, la enfermedad de Engelmann-Camurati suele presentarse de forma bilateral y simétrica, además puede estar asociada con alteraciones neurológicas y hematopoyéticas. 10 En la biopsia se diferencia de Ribbing porque muestra actividad osteoblástica y osteoclástica, con la consiguiente formación y resorción ósea. El diagnóstico se confirma mediante estudios genéticos del gen TGFB1 y su mutación en la región 19q13. ...
... Tablo-1. Romatoid artritte remisyonu tanımlamak için kullanılan ölçütler (5 (7). DAS28'e göre remisyonda kabul edilen hastaların sıklıkla gerçek remisyondan ziyade minimal hastalık aktivitesine sahip olduğu ultrasonografi (USG) ve manyetik rezonans (MR) görüntülemelerinde sinovite ait bulguların varlığı ile gösterilmiştir. ...
... Indeed, this very rare subtype of severe muscle damage is more frequent in patients with Sjögren's than in the general population; indeed, the prevalence of muscle damage is almost 500 times higher in Sjögren's (20). In the ASSESS cohort, 0.5% of patients had IBM (28). This condition should be considered in patients with long-lasting Sjögren's and myositis not responding to immunosuppressive treatment. ...
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... As far as rheumatological diseases are concerned, previous studies have focused mainly on cohorts of patients suffering from psoriasis or on cohorts of patients with neuropathic pain and chronic inflammatory diseases, to investigate the physiopathology of pain in chronic inflammatory rheumatic diseases (CIRDs), showing that the highest prevalence of migraines was observed in patients with PsA, while the highest prevalence of neuropathic pain was found among patients with spondyloarthritis (SpA) [15][16][17]. ...
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... Alterations are usually locat ed at several sites of the body. Medication with metho trexate and etanercept was found to be ineffective [37]. ...
