Jazmyne Barney's research while affiliated with University of Kentucky and other places
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Publications (4)
The deleterious effects of PCB 126 are complex, and the role of the liver in modifying toxic insult is not well understood. We utilized metabolomics approaches to compare liver metabolites significantly affected by PCB 126 in control mice and a diet induced liver injury mouse model. In this 14-week study, mice were fed either an amino acid suppleme...
Exposure to dioxins and related persistent organic pollutants likely contributes to cardiovascular disease (CVD) risk through multiple mechanisms including the induction of chronic inflammation. Epidemiological studies have shown that leaner individuals may be more susceptible to the detrimental effects of lipophilic toxicants because they lack lar...
The liver is vital for xenobiotic and endobiotic metabolism. Previously, we demonstrated that a compromised liver worsened toxicity associated with exposure to polychlorinated biphenyls (PCBs), through disruption of energy homeostasis. However, the role of a compromised liver in defining dioxin-like PCB126 toxicity on the peripheral vasculature and...
Citations
... Previous studies on PCB exposure have mostly focused on the association between PCBs and individual medical conditions. Evidence suggests that PCB exposure increases the risk of hypertension 9 , diabetes 10 , pulmonary arterial hypertension 11 , and liver diseases 12 . Plasma component analysis has revealed that PCB exposure impedes hematopoietic function, leading to in ammation and oxidative stress in the body 13 . ...
... In general, N-6 PUFAs are implicated in promoting in ammation as the precursors of pro-in ammatory molecules (22). Another study in mice showed that exposure to an organic pollutant increased the amount of docosatrienoate (22:3n6) in the liver, while increasing in ammation and exacerbating atherosclerosis (23). In relation to 2-hydroxyarachidate, the only existing information in connection to steatotic liver disease is, to our knowledge, an observed elevation in the plasma of individuals with severe insulin-resistant diabetes (24). ...
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... In addition to hepatic outcomes, PCB exposures have also been associated with cardiovascular outcomes including hypertension, endothelial dysfunction, and atherosclerosis (38)(39)(40). PCB disruption of the heart-liver axis has also been reported (21,41). Established mechanisms for PCB-mediated TAFLD include hepatic xenobiotic receptor activation and subsequent endocrine, metabolic, and signaling disruption, in addition to other offreceptor target effects such as gut microbiota alterations and pancreatic toxicity (15). ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/367848896647168-1464713419028_Q64/Banrida-Wahlang.jpg)
