Javier Diez-Garcia's research while affiliated with Biocruces Health Research Institute and other places
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Publications (4)
Podocalyxin (PODXL), a cell surface sialomucin expressed in diverse types of normal and malignant cells, mediates cellular adhesion to extracellular matrix and cell-to-cell interaction. A previous study reported the expression of PODXL protein on monocytes undergoing macrophage differentiation, yet the expression of this molecule in other antigen p...
Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse or remain refractory due to drug resistance, prese...
Unlabelled:
There is an actual need of advanced materials for the emerging field of bioelectronics. One commonly used material is the conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (
Pedot:
PSS) due to its general use in organic electronics. However, depending on the application in bioelectronics,
Pedot:
PSS is not...
Knowledge on the normal structure and molecular composition of the peripheral nerves is essential to understand their pathophysiology and to select the regeneration strategies after injury. However, the precise lipid composition of the normal peripheral nerve is still poorly known. Here, we present the first study of distribution of individual lipi...
Citations
... In existing research reports, among the upregulated differential genes, MBD4 is involved in the DNA repair mechanism, 35 and TIMP3 and PODXL are related to ECM and cell adhesion. 36,37 In summary, LUSC radiotherapy-resistant cell lines can be obtained by fractionated radiotherapy of LUSC cell lines. Using this preclinical cell model, we can further explore potential molecular markers of radioresistance in LUSC. ...
... The interactions between PODXL, ezrin, and NHERF-1/2 have been reported to activate intracellular signaling including Rac1, RhoA, Cdc42, mitogen-activated protein kinase, and phosphatidylinositol-3 kinase pathways to promote motility [12]. PODXL has been shown in gain-and loss-of-function studies to play an essential role in tumor progression by promoting migration, invasiveness, stemness, and metastasis in a variety of cancer cells [15]. Therefore, PODXL has acquired increasing attention as a target of tumor immunotherapy. ...
... Various strategies, such as PSS-based block-copolymers, biopolymers, selfdoped thiophenes, or conducting additives were explored. [5,[10][11][12][13][14] While these approaches presented improvements in many aspects such as biocompatibility, stretchability, processability, or conductivity, none of them have been able to surpass the performance of PEDOT:PSS. [15][16][17][18] Nature-inspired systems, such as proteins could serve as dopants capable to fulfil a wide range of requirements. ...
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... Regarding the study of chain length and unsaturation, as shown in Figure 8, our results are in agreement with what has been observed in other studies [49]: chains are mainly composed of 16 and 18 carbon atoms. Meanwhile, at the level of unsaturation, we found that the most present chains are those with one unsaturated or non-unsaturated chain. ...
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