Janiel K. Ahkin Chin Tai's research while affiliated with Purdue University and other places
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Publications (6)
Atrazine (ATZ) is an herbicide commonly used on crops in the Midwestern US and other select global regions. The US Environmental Protection Agency ATZ regulatory limit is 3 parts per billion (ppb; μg/L), but this limit is often exceeded. ATZ has a long half-life, is a common contaminant of drinking water sources, and is indicated as an endocrine di...
Atrazine (ATZ) is the second most common agricultural herbicide used in the United States and is an endocrine disrupting chemical (EDC). Developmental exposure to ATZ can lead to significant behavioral and morphological alterations in exposed animals and their progeny suggesting the involvement of an epigenetic mechanism. Specific epigenetic mechan...
Atrazine (ATZ) is the second most commonly applied agricultural herbicide in the United States. Due to contamination concerns, the U.S. EPA has set the maximum contaminant level in potable water sources at 3 parts per billion (ppb; μg/l). Depending on the time of year and sampling location, water sources often exceed this limit. ATZ is an endocrine...
Atrazine (ATZ) is an agricultural herbicide. Due to persistence and contamination of drinking water sources, ATZ was banned by the European Union, but is still commonly used in the United States and other global regions. The US Environmental Protection Agency has set the maximum contaminant level at 3 μg/L in potable water, though concentrations ca...
Zebrafish (Danio rerio) are an integrative vertebrate model ideal for toxicity studies. The zebrafish genome is sequenced with detailed characterization of all life stages. With their genetic similarity to humans, zebrafish models are established to study biological processes including development and disease mechanisms for translation to human hea...
Atrazine (ATZ) is one of the most commonly used herbicides in the United States. Previous studies have hypothesized the role of ATZ as an endocrine disruptor (EDC), and developmental exposure to ATZ has been shown to lead to behavioral and morphological alterations. Specific epigenetic mechanisms responsible for these alterations, however, are yet...
Citations
... Another promising avenue is the study of vaccines or immunizations for inducing host epigenetic changes [38,39]. Increasingly, zebrafishes are employed to model epigenetic alterations in a variety of organ systems, especially following modifications through xenobiotic exposure [40][41][42][43][44][45][46], although we are not aware of studies demonstrating epigenetic changes in the zebrafish following immunization. There might also be benefits to comparing the epigenetic changes that occur following immunization of the zebrafish versus mammalian models as a means to validate the findings in the former. ...
... These observed increases in the level of catecholamines as a result of TBBPA-DHEE exposure could be linked to the observed abnormal zebrafish behavior in relation to hyperactivity (induction of stress/anxiety) since previous study correlates catecholamines release in the sympathetic nervous system with stress response (Steele et al., 2011). Additionally, the disruption of the endocrine system is accompanied by abnormal zebrafish development and behavior (Teng et al., 2017;Ahkin Chin Tai et al., 2021). This could partly explain the observed altered locomotion behavior and upregulation of expression level of mRNA of genes of FA metabolism and degradation in the KEGG enrichment analysis resulting in neuroendocrine disruption/neurotoxicity. ...
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... Embryos show optical transparency through the chorion during the early stages of life, facilitating the observation of morphological processes as well as physical movements [45]. Furthermore, it has 70% homology with the human genome (which increases to 82% when considering genes related to human diseases) [46]. There are several zebrafish transgenic lines, which facilitate the development of ecotoxicological studies with greater specificity [47]. ...
